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All Journal The Indonesian Biomedical Journal Eduvest - Journal of Universal Studies
Putranto, Indra Kusuma Adi
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Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Neuroscience Public Health Social Sciences

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The Effect of Sleeve Gastrectomy on the Improvement of Random Blood Glucose Levels in Obese Diabetic Rats Putranto, Indra Kusuma Adi; Mughni, Abdul; Boediono, B. Parish
Eduvest - Journal of Universal Studies Vol. 5 No. 4 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i4.44797

Abstract

This experimental study investigates the impact of sleeve gastrectomy on blood glucose regulation in obese diabetic rats. Obesity and Type 2 diabetes are major health concerns globally, and sleeve gastrectomy has been identified as an effective bariatric surgery for managing these conditions. The study used a randomized control group pretest-posttest design with two groups: one underwent sleeve gastrectomy, and the other served as a control group. The rats' body weight and blood glucose levels were monitored before and after the procedure. The results demonstrated a significant reduction in random blood glucose levels in the group that underwent sleeve gastrectomy compared to the control group, indicating an improvement in glucose metabolism. These findings suggest that sleeve gastrectomy effectively improves blood glucose levels, potentially due to changes in hormonal and metabolic pathways, particularly the enhancement of GLP-1 secretion, which plays a role in insulin sensitivity. The implications of this research highlight the potential of sleeve gastrectomy as a therapeutic intervention for obesity-related Type 2 diabetes. Further studies are recommended to explore the underlying mechanisms and long-term effects of this procedure in humans and its broader applications in metabolic disease management.
Combined Sleeve Gastrectomy and Omentoplasty Improves Inflammation and Insulin Resistance in Obese Rats with Type II Diabetes Mellitus: A Randomized Controlled Trials Nugroho, Heri; Mughni, Abdul; Putranto, Indra Kusuma Adi; Prasetya, Anggoro Teguh; Novitasari, Vicky
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.3047

Abstract

BACKGROUND: Diabetes mellitus (DM) is often associated with obesity, which can lead to chronic inflammation. Sleeve gastrectomy (SG) is a common treatment for obesity. Combining SG with omentoplasty, might help reducing inflammation in pancreatic beta cells. However, there is limited research regarding the combined effects of SG and omentoplasty in type 2 DM (T2DM). This study was conducted to fill this gap by evaluating the impact on body weight, insulin resistance, glucagon expression, and levels of interleukins (IL)-1, IL-6, and IL-10 in obese rats with type II DM.METHODS: An experimental study was conducted on 18 obese Wistar rats with DM that were randomized into: control, T1 (SG), and T2 (SG + omentoplasty). SG involved the surgical removal of a portion of the stomach to reduce its size, while omentoplasty utilized the omentum to target inflammation in pancreatic beta cells. Venous blood samples were taken from subjects one day before and ten days after the intervention to measure the biomedical parameters with various methods. Data was statistically analyzed using paired t-tests for pre-test and post-test differences, and Post Hoc tests or Mann-Whitney tests for hypothesis testing.RESULTS: All rats were confirmed to have obesity and DM according to the Lee index and blood glucose levels. T2 group exhibited a significant decrease in body weight, homeostatic model assessment of insulin resistance (HOMA-IR) values were lower, and glucagon expression, IL-1, IL-6, and IL-10 levels were significantly greater compared to both control and T1 groups.CONCLUSION: The combination of SG and omentoplasty significantly improves inflammation and insulin resistance in obese rats with T2DM.KEYWORDS: diabetes mellitus, sleeve gastrectomy, omentoplasty, inflammation, obesity
Co-Authors Abdul Mughni Boediono, B. Parish Heri Nugroho Novitasari, Vicky Prasetya, Anggoro Teguh