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All Journal Chemistry Indonesian Journal of Chemical Research Bioculture Journal
Lubis, Yuni Aldriani
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science Social Sciences

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Synthesis, Microstructure, Optical Properties, and Sensitive Amoxicillin Detection of Carbon Dots Lubis, Yuni Aldriani; Gea, Saharman; Lubis, Muhammad Frassetia; Pai, Woei Wu Larry; Marpongahtun, Marpongahtun
Indonesian Journal of Chemical Research Vol 13 No 1 (2025): Edition for May 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.13-yun

Abstract

The detection of amoxicillin has been successfully carried out using C-dot fluorescence probes made from d-glucose and urea. The fluorescence probe has an intense bright blue emission under UV light at 395 nm and and depends on the excitation and depends on the excitation. Raman studies successfully showed a D peak at 1381 cm-1 and a G peak at 1586 cm-1 associated with graphitic and amorphous structures. The absorption peaks in UV-vis spectroscopy confirm transitions at 275 nm (π → π*) and 322 nm (n → π*) with the presence of conjugated C=C and carbonyl (C=O) functional groups. The results of the fluorescence test show a bright blue color, with its intensity measured at an excitation of 365 nm. This can be attributed to nitrogen incorporation on the surface of the C-dots derived from urea, resulting in a quantum yield of 54%. This fluorescence probe is highly sensitive in detecting amoxicillin, as evidenced by the successful detection of AMX at concentrations of 10–30 μM and a resulting LOD of 5.75443×10−7 nM. The microstructure shows a uniform size of C-dot nanoparticles, and C-dot modeling was created. C-dot probes have an LOD of 5.75443×10−7 nM, indicating high sensitivity in detecting AMX.
Exploring the role of biomass-derived carbon quantum dots: Hydrothermal carbonization, bioimaging in vivo/in vitro, and biomedical application Lubis, Yuni Aldriani
Bioculture Journal Vol. 3 No. 2: January (2026)
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/bioculture.v3i2.2026.3206

Abstract

Background: Carbon-based nanoparticle classes consisting of various subgroups based on morphology and crystallinity are called carbon dots (CQDs). The physical, chemical, and optical properties of CQDs can be modified using the simple pot synthesis technique. Additionally, its non-toxic nature, biocompatibility, physical and chemical responsiveness, resistance to chemical and photo bleaching, and low cost make it suitable for various purposes, such as biomedical imaging applications. Biomass waste, which has been widely discarded without economic utilization and potential, can surprisingly be used as a precursor for CQDs. Method: The literature was systematically collected from major databases. Studies from 2017–2025 were analyzed based on synthesis strategies, surface functionalization, and biological performance. Its potential in the medical field is highly advantageous. CQDs have fluorescence that is useful for biomedical imaging both in vivo and in vitro. The hydrothermal carbonization approach is also discussed in more detail, highlighting its green and sustainable synthesis, as well as the ease of the synthesis process. Finding: It was found that CQDs have compatibility and adjustable optical properties. Its fluorescence can clearly record tissues, body care, aging, and living cells. Utilizing renewable biomass precursors offers an environmentally friendly and cost-effective route for synthesizing fluorescent nanoprobes with excellent water solubility, tunable emission, and low cytotoxicity. Additionally, in vitro studies reinforce CQDs as multicolor fluorescent probes, and in vivo studies demonstrate that CQDs have low toxicity, rapid clearance, are safe, and biocompatible. Conclusion: This paper delves into the remarkable potential of CQDs to provide insights into how fluorescent inks are truly essential in biomedical imaging. Novelty/Originality of this article: This study provides a comprehensive and updated synthesis of CQD research spanning up to 2025, specifically focusing on the transition from "waste to nanoprobe."
Co-Authors Lubis, Muhammad Frassetia Marpongahtun, Marpongahtun Pai, Woei Wu Larry Saharman Gea