Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Acta Biochimica Indonesiana
Alphanto, Alfred H
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Antioxidant activity of Crescentia cujete extract: effects on oxidative stress in the hearts of hypoxic rats Limanan, David; Setiady, Brandon Alexander; Sentosa, Belinda; Alphanto, Alfred H; Rudianti, Selly Herlia; Ferdinal, Frans
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.201

Abstract

Background: The heart is highly susceptible to oxidative stress. Hypoxia can induce oxidative stress in the heart, leading to cardiac damage. Objective: This study investigated the antioxidant effects of Crescentia cujete extract on oxidative stress in hypoxic rat hearts. Methods: Antioxidant capacity was evaluated using DPPH assay. Sprague Dawley rats were divided into eight groups: four received C. cujete extract (400 mg/kg/day for 14 days) and four served as controls. Hypoxia was induced for 3, 7, and 14 days using a hypoxic chamber (8% O₂, 92% N₂). Heart tissue was analyzed for malondialdehyde (MDA), glutathione (GSH), and catalase activity. Results: C. cujete extract demonstrated moderate antioxidant capacity (IC50 = 158.45 µg/mL). In extract-treated rats, MDA levels were significantly lower compared to controls, while catalase activity was significantly higher. GSH levels were higher in treated groups but not statistically significant. Histopathological analysis revealed less cardiac necrosis in extract-treated groups. Conclusion: C. cujete extract demonstrates protective effects against hypoxia-induced cardiac oxidative stress. These findings suggest potential as complementary therapy for oxidative cardiac damage, although further studies are needed to establish clinical efficacy and safety.
Co-Authors David Limanan Frans Ferdinal Rudianti, Selly Herlia Sentosa, Belinda Setiady, Brandon Alexander