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All Journal Journal of Stem Cell Research and Tissue Engineering Jurnal Manajemen Pelayanan Kesehatan (The Indonesian Journal of Health Service Management)
Ferni
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Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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EVALUASI MANFAAT PENERAPAN CLINICAL PATHWAY SECTIO CAESAREA DI RUMAH SAKIT BETHESDA LEMPUYANGWANGI Ferni
Journal of Health Service Management Vol 27 No 4 (2024)
Publisher : Departemen of Health Policy and Management, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta Jl. Farmako Sekip Utara Yogyakarta 55281 Telp 0274-547490

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpk.v27i4.11987

Abstract

Background: Cesarean section (SC) is one of the most performed surgical procedures in the world, as well as in Bethesda Lempuyangwangi Hospital (RSBL). This action is included in the high volume and high-cost category, so a guide is needed to reduce variations in patient care. Clinical pathway (CP) is a tool to improve the process of preparation, management, and clinical outcomes of patients. RSBL has developed a CP for SC since 2019, but there has never been an evaluation of the benefits of its implementation. Objectives: To evaluate the benefits of SC CP implementation on laboratory test compliance, prophylactic antibiotic prescribing compliance, incidence of surgical wound infection, length of stay, and APGAR score. Methods: This was an observational analytic study with an ex-post facto research design. The subjects of this study were all patients undergoing elective SC surgery at RSBL who met the inclusion criteria in the period before and after the implementation of SC CP. The variables evaluated were compliance with laboratory tests, compliance with prophylactic antibiotic prescribing, incidence of surgical wound infection, length of stay, and APGAR score. Results: Compliance of laboratory tests increased from 6.7% to 100%, compliance of prophylactic antibiotic prescribing increased from 3.4% to 84.3%, the incidence of surgical wound infection decreased from 1.10% to 0.0%, and variation in the length of stay decreased from 2-4 days to 3 days (100%). The mean first-minute APGAR score did not change (7), while the 5th and 10th-minute scores decreased from 9 to 8, and 10 to 9, respectively. Conclusions: The implementation of CP SC was beneficial in improving laboratory testing compliance and prophylactic antibiotic prescribing compliance, reducing the incidence of surgical wound infection, and reducing variation in the length of stay, but could not improve the APGAR score. Keywords: Clinical pathway, sectio caesarea, laboratory testing, prophylactic antibiotic, length of stay
RECENT ADVANCES IN STEM CELLS-BASED THERAPY FOR HIV ELIMINATION Herdyan, Deta Intan; Ferni; Nugraha, Adi
Journal of Stem Cell Research and Tissue Engineering Vol. 9 No. 2 (2025): Journal of Stem Cell Research and Tissue Engineering
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v9i2.85309

Abstract

The persistent latent reservoir of HIV remains the greatest barrier to achieving a functional cure. Stem-cell–based therapy has emerged as a promising approach to eliminate or durably suppress HIV by reconstructing the immune system with HIV-resistant cells. This review summarizes recent progress (2021–2025) in stem-cell–based therapeutic strategies for HIV elimination, including hematopoietic stem cell transplantation (HSCT), gene-edited autologous stem cells, and stem-cell–derived engineered immune effectors. A narrative literature review was conducted using PubMed and Google Scholar databases for articles published between 2021 and 2025. Keywords included “HIV cure,” “stem cell therapy,” “hematopoietic stem cell transplantation,” “CCR5 gene editing,” “CAR-T cells,” and “HSPC-based HIV therapy.” Allogeneic HSCT using CCR5Δ32/Δ32 donors provided proof-of-concept for HIV elimination. Recent reports demonstrate additional remission cases using cord blood or haploidentical grafts. Advances in CRISPR/Cas9-mediated CCR5 disruption of autologous hematopoietic stem and progenitor cells (HSPCs) achieved high editing efficiency and successful engraftment. Stem-cell–derived CAR-T and CAR-NK cells showed potent antiviral effects in preclinical and early clinical studies. However, challenges remain in eradicating viral reservoirs, preventing viral escape, and ensuring long-term safety of gene editing. Stem-cell–based therapies represent a rapidly evolving frontier toward an HIV cure. Emerging technologies in gene editing and engineered cell therapy promise scalable, safer, and potentially curative approaches, though significant translational and ethical hurdles must be addressed before widespread clinical application.
Co-Authors Adi Nugraha Herdyan, Deta Intan