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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Sains dan Ilmu Terapan
Widiya Zulvania
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Computer Science & IT Engineering Health Professions Medicine & Pharmacology Nursing Public Health

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Kajian Struktur Dan Mekanisme Senyawa Aktif Kayu Manis Sebagai Terapi Alternatif Diabetes Melitus: Tinjauan Kimia Medisinal Saeful Amin; Jelin Mutiara Guswara; Widiya Zulvania; Adisti Rahma
Jurnal Sains dan Ilmu Terapan Vol. 8 No. 1 (2025): Jurnal Sains dan Ilmu Terapan
Publisher : Politeknik Kampar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59061/jsit.v8i1.962

Abstract

Diabetes mellitus is a chronic metabolic disease characterised by hyperglycaemia due to impaired insulin secretion or action. Conventional therapies often cause side effects and limited long-term efficacy, thus encouraging the exploration of alternative therapies based on natural compounds. Cinnamon (Cinnamomum spp.) has been empirically known to have antidiabetic effects, mainly through the content of bioactive compounds such as cinnamaldehyde, eugenol, cinnamic acid, coumarin, and proanthocyanidin.
Kajian Potensi Senyawa Aktif Bahan Alam sebagai Inhibitor Human Epidermal Growth Factor Receptor 2 (Her-2) pada Kanker Payudara : Kajian Penambatan Molekuler Saeful Amin; Anantha Puspatiara; Fina Awaliah; Widiya Zulvania
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4602

Abstract

Breast cancer is the most prevalent type of cancer in women worldwide, with approximately 2.3 million new cases or 11.7% of all cancer cases. Human Epidermal Growth Factor Receptor 2 (HER-2) is one of the important therapeutic targets in breast cancer that is overexpressed in 15-25% of cases. Conventional cancer treatments such as chemotherapy often cause adverse side effects, so safer alternative therapies are needed. This study aims to assess the potential of active compounds from medicinal plants as HER-2 inhibitors through a molecular docking approach. The literature review method was used by analysing related research articles in the last five years obtained from PubMed and Google Scholar databases. The results showed that several active compounds have high potential as HER-2 inhibitors, including beta cystosterol from guava leaves (Psidium guajava L.) with a binding energy value of -12.3 kcal/mol, vitexin from dandang gendis (Clinacanthus nutans L.) with a value of -9.3 kcal/mol, and isovitexin from basil mekah (Ocimum gratissimum) with a value of -9.11 kcal/mol. These findings provide a basis for further development of natural active compounds as potential breast anticancer drug candidates with minimal side effects.
Co-Authors Adisti Rahma Anantha Puspatiara Fina Awaliah Jelin Mutiara Guswara Saeful Amin