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Evaluation and antibacterial testing of Mangosteen leaf extract cream (Morinda Citrifolia l) as acne-prone Kristijono, Ary; Jaroh, Assolychathu; Rosyida, Firdania Firdaus; Prasetya, Bandhi
Riset Informasi Kesehatan Vol 14 No 2 (2025): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v14i2.1026

Abstract

Background: Acne is a common skin condition caused by the proliferation of bacteria, often leading to inflammation and infection. Morinda citrifolia L. (Noni) has been traditionally used for its medicinal properties, including its antibacterial effects. This study aims to evaluate the antibacterial activity of Noni leaf extract cream and its potential as an acne treatment.. Method: The study involved preparing a cream formulation using ethanol extract of Noni leaves at varying concentrations (1.25%, 2.50%, and 5.00%). The antibacterial activity was tested using the Kirby Bauer disk diffusion method against Streptococcus pyogenes, a common bacterium associated with acne. The cream was also subjected to organoleptic testing, pH testing, viscosity measurements, spreadability tests, and adhesion tests to assess its quality and stability. Results: The cream showed significant antibacterial activity, with a zone of inhibition ranging from 5.79 mm to 9.16 mm, depending on the concentration of Noni leaf extract. The highest antibacterial activity was observed at 5.00% concentration, with a large inhibition zone of 9.16 mm. Additionally, the cream maintained a stable pH and showed good physical properties, including uniform consistency and spreadability. The cream did not exhibit any significant changes in appearance, smell, or texture during the stability testing. Conclusion: The results indicate that Noni leaf extract cream has promising antibacterial effects, particularly at higher concentrations, and could effectively treat acne. The cream demonstrated satisfactory quality and stability, making it a viable candidate for further development in acne treatment formulations.
Formulasi dan Evaluasi Sediaan Balsam Dari Kombinasi Minyak Atsiri Alpina Galanga dan Ekstrak Kaemferia Galanga: Formulation and Evaluation of a Balm Preparation Containing a Combination of Alpinia galanga Essential Oil and Kaempferia galanga Extract Jaroh, Assolychathu; Remanti, Etis; firduas, Firdania; Kristijono, Ary
Jurnal Abdi Keperawatan dan Kedokteran Vol 5 No 1 (2026): Jurnal Abdi Kesehatan dan Kedokteran
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/jakk.v5i1.158

Abstract

The utilization of natural products as alternative therapeutic agents has received growing attention, particularly in the development of topical balm formulations for muscle pain relief. Galangal (Alpinia galanga) and kencur (Kaempferia galanga) are medicinal plants rich in bioactive compounds that may exert therapeutic effects while providing characteristic aromas that enhance user acceptability. This study aimed to formulate a topical balm containing a combination of galangal essential oil and kencur extract and to evaluate the physical quality of the resulting formulations. An experimental laboratory study was conducted by preparing three balm formulations with varying concentrations of galangal essential oil, while the concentration of kencur extract was maintained constant. No human subjects were involved. The evaluated parameters included organoleptic characteristics (color, consistency, and odor), homogeneity, viscosity, spreadability, adhesiveness, and pH. All physical evaluations were performed using standardized laboratory procedures and instruments, including a viscometer, pH meter, and glass plates. The results demonstrated that all formulations produced semi-solid balms with a brownish-white appearance and showed good homogeneity without any phase separation. Significant differences were observed among the formulations in viscosity, spreadability, and adhesiveness. Formulation 3 exhibited the most favorable physical properties, with a viscosity of 26,933 ± 153, spreadability of 5.7 ± 0.10, and adhesiveness of 7.3 ± 0.10. Furthermore, all formulations displayed pH values within the physiological range of human skin, with Formulation 3 showing a pH of 5.9 ± 0.10, which was closest to normal skin conditions. In conclusion, the combination of Alpinia galanga essential oil and Kaempferia galanga extract can be successfully formulated into a stable topical balm that meets essential physical quality requirements. Formulation 3 was identified as the most suitable formulation and demonstrates strong potential for further development as a safe and effective herbal topical product.