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All Journal Jurnal Inovasi Farmasi Indonesia Jurnal Abdi Kesehatan dan Kedokteran
Remanti, Etis
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Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Optimasi Formulasi Sediaan Balsem Ekstrak Belimbing Wuluh (Averrhoa Bilimbi L.): Formulation Optimization of Starfruit Extract Balm Preparation (Averrhoa Bilimbi L.) Rosyida, Firdania Firdaus; Mustika, Silvia Wahyu; Jaroh, Assolychathu; Remanti, Etis; Kristijono, Ary; Sukmawati, Datin An Nisa
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 7 No. 1 (2025): Volume 7 No 1 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v7i1.7039

Abstract

Balsem merupakan bentuk sediaan farmasi yang bermanfaat sebgai bahan pereda nyeri. Belimbing wuluh secara Konvesional dapat dimanfaatkan untuk mengatasi pembengkakan, karena mengandung terdapat kandungan senyawa flavonoid, tanin, saponin dan akaloid sebagai anti inflamasi. Senyawa ini memiliki kemampuan untuk menghambat enzim pro-inflamasi, seperti siklooksigenase (COX) dan lipoksigenase (LOX). Tujuan penelitian ini adalah optimasi formulasi sediaan balsem ekstrak blimbing wuluh dengan konsentrasi ekstrak 2% dengan bahan tambahan seperti paraffin solidum (12 %), menthol (1 %), methil salisilat (10 %), vaselin album (ad 100%), dan champora sebagai variasi formulasi dengan konsentrasi F1=6% F2=7% F3=8%.  Didapatkan hasil evaluasi fisik sediaan balsem ekstrak belimbing wuluh formula 2 (F2) memiliki nilai tertinggi pada hampir seluruh parameter fitokimia, yaitu flavonoid sebesar 58,1 ± 2,0 mg, tanin 28,3 ± 1,2 mg/g, saponin 3,83 ± 0,15%, serta alkaloid 2,08 ± 0,10 mg/g. Daya sebar F2 sebesar 7,58 ± 0,20 cm, daya lekat. Nilai pH F2 yaitu 5,80 ± 0,06, dan pH F2 yaitu 5,80 ± 0,06, menandakan bahwa F2 memiliki kandungan senyawa aktif paling optimal.
Formulasi dan Evaluasi Sediaan Balsam Dari Kombinasi Minyak Atsiri Alpina Galanga dan Ekstrak Kaemferia Galanga: Formulation and Evaluation of a Balm Preparation Containing a Combination of Alpinia galanga Essential Oil and Kaempferia galanga Extract Jaroh, Assolychathu; Remanti, Etis; firduas, Firdania; Kristijono, Ary
Jurnal Abdi Keperawatan dan Kedokteran Vol 5 No 1 (2026): Jurnal Abdi Kesehatan dan Kedokteran
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/jakk.v5i1.158

Abstract

The utilization of natural products as alternative therapeutic agents has received growing attention, particularly in the development of topical balm formulations for muscle pain relief. Galangal (Alpinia galanga) and kencur (Kaempferia galanga) are medicinal plants rich in bioactive compounds that may exert therapeutic effects while providing characteristic aromas that enhance user acceptability. This study aimed to formulate a topical balm containing a combination of galangal essential oil and kencur extract and to evaluate the physical quality of the resulting formulations. An experimental laboratory study was conducted by preparing three balm formulations with varying concentrations of galangal essential oil, while the concentration of kencur extract was maintained constant. No human subjects were involved. The evaluated parameters included organoleptic characteristics (color, consistency, and odor), homogeneity, viscosity, spreadability, adhesiveness, and pH. All physical evaluations were performed using standardized laboratory procedures and instruments, including a viscometer, pH meter, and glass plates. The results demonstrated that all formulations produced semi-solid balms with a brownish-white appearance and showed good homogeneity without any phase separation. Significant differences were observed among the formulations in viscosity, spreadability, and adhesiveness. Formulation 3 exhibited the most favorable physical properties, with a viscosity of 26,933 ± 153, spreadability of 5.7 ± 0.10, and adhesiveness of 7.3 ± 0.10. Furthermore, all formulations displayed pH values within the physiological range of human skin, with Formulation 3 showing a pH of 5.9 ± 0.10, which was closest to normal skin conditions. In conclusion, the combination of Alpinia galanga essential oil and Kaempferia galanga extract can be successfully formulated into a stable topical balm that meets essential physical quality requirements. Formulation 3 was identified as the most suitable formulation and demonstrates strong potential for further development as a safe and effective herbal topical product.
Co-Authors Datin An Nisa Sukmawati Firdania Firdaus Rosyida firduas, Firdania Jaroh, Assolychathu Kristijono, Ary Mustika, Silvia Wahyu