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All Journal Jurnal Insan Farmasi Indonesia Jurnal Kesehatan dr. Soebandi
Utami, Rani Nur Ayu
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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FORMULASI DAN UJI STABILITAS GEL MASK FRAKSI ETIL ASETAT BUNGA TELANG (Clitoria ternatea L.) SEBAGAI ANTIOKSIDAN Puspitasari, Dewi Fitriani; Utami, Rani Nur Ayu; Wildan, Achmad
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2423

Abstract

The ethyl acetate fraction of butterfly pea flower was found to have higher antioxidant activity than other fractions. This fraction can be utilized in making gel mask preparations, as an alternative to topical antioxidants. The purpose of this study was to formulate the ethyl acetate fraction in a gel mask preparation, and test the physical characteristics and stability of antioxidant activity before and after being stored for 3 months at room temperature. Extraction of telang flowers, using 70% ethanol, followed by fractionation with n-hexane, ethyl acetate and water. The results of the ethyl acetate fraction were tested for antioxidant activity, then formulated in a gel mask preparation. Evaluation of the physical characteristics of the preparation includes organoleptic test, homogeneity, pH, viscosity, adhesion, spreadability, and antioxidant activity test, before and after 3 months storage with DPPH. The results of the antioxidant activity test of the ethyl acetate fraction obtained a value of 25.14 µg/mL. The results of the physical characteristics of the gel have a pH 5.18 ± 0.035, viscosity 9541 ± 32.14 cps, adhesion 2.04 ± 0.015 seconds, spreadability 4.55 ± 0.015 cm. The antioxidant activity of the gel decreased after storage for 3 months.
Phenolic Assay and Antioxidant Activity of Ethyl Acetate and Water Fractions of Ethanol Extract of Butterfly Pea Flower by DPPH and FRAP Methods Fitriani, Dewi; Utami, Rani Nur Ayu; Ta’ati, Rina Nur Ayu
Jurnal Kesehatan dr. Soebandi Vol 13 No 2 (2025): Vol. 13 No. 2 (2025): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v13i2.845

Abstract

Antioxidants play an important role in human life. Many studies have been conducted to discover the potential of antioxidants sourced from nature. Several methods can be used to test antioxidants. These methods include FRAP, ABTS, and DPPH. All three methods are widely used because they are stable and relatively easy to use. Several studies on TAC (Total Antioxidant Capacity) have reported different results regarding antioxidant testing using different methods on the same material. This study aims to test the ethyl acetate and water fractions of butterfly pea flower extract using the DPPH and FRAP methods and to compare the results with the findings of previous researchers who tested using the ABTS method. The research method began with the extraction of butterfly pea flowers using 70% ethanol solvent, followed by a total phenolic test using the Folin Ciocalteu method. Next, fractionation was carried out, and the ethyl acetate and water fractions were then tested for antioxidant activity using the DPPH method, while FRAP was performed for the ethyl acetate fraction. Quercetin was used as a reference standard. The results of the antioxidant activity test of butterfly pea flowers using the DPPH method showed an IC50 value of 27.63 ppm ±4.11 in the ethyl acetate fraction and 54.70 ppm ±2.22 in the water fraction, while the IC50 in the FRAP method was 97.47 ppm ±3.2 in the ethyl acetate fraction. DPPH and ABTS did not show significant differences in the antioxidant activity test results, but showed different results in FRAP.
Co-Authors Achmad Wildan DEWI FITRIANI Puspitasari, Dewi Fitriani Ta’ati, Rina Nur Ayu