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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Zona Kebidanan : Program Studi Kebidanan Universitas Batam
Mahanani, Annisah
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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HUBUNGAN PENGETAHUAN KESEHATAN REPRODUKSI DENGAN PERILAKU SEKSUAL BERESIKO PADA REMAJA SMA DI DESA MOJOAGUNG KAB.PATI: KESEHATAN REPRODUKSI Wahyuni, Sri; Parmila Hesti S, Naomi; Mahanani, Annisah
Zona Kebidanan: Program Studi Kebidanan Universitas Batam Vol 15 No 2 (2025): APRIL
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zkeb.v15i2.1762

Abstract

This study aims to analyze the relationship between reproductive health knowledge and risky sexual behavior among high school adolescents in Banjarmasin City. This cross-sectional research involved 256 students aged 15-18 years selected through stratified random sampling from five public high schools. Data were collected using validated questionnaires for reproductive health knowledge and risky sexual behavior. Data analysis used chi-square test and multivariate logistic regression. Results showed that 64.8% of respondents had adequate reproductive health knowledge, while 35.2% had inadequate knowledge. Regarding risky sexual behavior, 23.4% of respondents reported engaging in at least one form of risky sexual behavior. Statistical analysis revealed a significant relationship between reproductive health knowledge and risky sexual behavior (p=0.001; OR=3.28; 95% CI: 1.92-5.61), indicating that adolescents with inadequate knowledge were 3.28 times more likely to engage in risky sexual behavior. The relationship remained significant after controlling for variables such as age, gender, parental communication, peer influence, and access to information. The study concludes that improving reproductive health knowledge among adolescents is crucial in reducing risky sexual behavior. Recommendations include strengthening reproductive health education in schools, enhancing parent-adolescent communication, and developing comprehensive reproductive health programs tailored to adolescents' needs.
Molecular Docking Study of Quercetin as an IGF1R Inhibitor for Anticancer Potential Suryani, Puput Eka; Putri, Raden Roro Erni Kusuma; Mahanani, Annisah
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p60-68

Abstract

Cancer is one of the leading causes of death in the world and its incidence continues to increase every year. In 2024, there will be more than 20 million new cases of cancer with a death toll reaching 10 million people. This high mortality rate is a challenge in itself in developing effective, selective, and minimal side effect cancer therapies. One approach that is currently being widely developed is therapy based on suppressing the cancer cell growth signal pathway, one of which is through inhibition of the Insulin-like Growth Factor 1 Receptor (IGF1R) receptor which is known to play an important role in proliferation, metastasis, and resistance to cancer therapy. From several experiments based on quercetin as an IGF1R inhibitor, there has been no explanation whether quercetin is capable of being an IGF1R inhibitor agent at the intracellular level. This study aims to evaluate the role of quercetin on the kinase domain and its activity at the ATP-binding site in silico through the molecular docking method. Based on the results of the study, it was concluded that quercetin is capable of acting as an IGF1R protein inhibitor. This was confirmed by several bonds formed between residues Val331A, Asp292A, Glu294A, Ser287A through hydrogen bonds with quercetin
Co-Authors Parmila Hesti S, Naomi Putri, Raden Roro Erni Kusuma Sri Wahyuni suryani, puput eka