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All Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI)
Alioes , Yustini
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Immunology & microbiology Medicine & Pharmacology Public Health

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Daya Hambat Ekstrak Etanol Biji Petai terhadap Bakteri Pseudomonas aeruginosa Ramadhan, Mario Arya; Alioes , Yustini; Eka Putra , Andani; Suharti , Netti; Aliska, Gestina; Hasmiwati, Hasmiwati
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i2.1402

Abstract

Latar Belakang: Pseudomonas aeruginosa adalah penyebab umum dari infeksi nosokomial. Meningkatnya angka Multidrug resistant Pseudomonas aeruginosa menyebabkan terjadinya peningkatan biaya pengobatan sehingga diperlukan pengobatan alternatif murah dan efektif, contohnya adalah tanaman petai (Parkia speciosa Hassk.). Biji petai (Parkia speciosa Hassk.) berpotensi untuk menjadi obat alternatif terhadap penyakit yang ditimbulkan Pseudomonas aeruginosa. Objektif: Penelitian ini bertujuan untuk mengetahui perbedaan diameter zona hambat pada konsentrasi (25%, 50%, 75%, dan 100%) ekstrak etanol biji petai (Parkia speciosa Hassk.) terhadap bakteri Pseudomonas aeruginosa. Metode: Penelitian ini berupa penelitian eksperimental menggunakan metode difusi cakram. Biji petai diekstraksi menggunakan teknik maserasi dengan pelarut etanol. Ekstrak kental dilarutkan menjadi konsentrasi 25%, 50%, 75%, dan 100%. Kertas saring yang telah direndam di dalam konsentrasi uji diletakkan di atas media agar yang telah ditanami bakteri Pseudomonas aeruginosa. Cawan perti selanjutnya diinkubasi selama 24 jam. Diameter zona hambat diukur menggunakan jangka sorong. Data hasil penelitian dianalisis secara statistik. Hasil: Hasil penelitian menunjukkan rerata diameter zona hambat tiap konsentrasi secara berurutan adalah 2,20 mm (25%), 6,40 mm (50%), 7,05 mm (75%), dan 7,60 mm (100%). Kesimpulan: Terdapat perbedaan diameter yang signifikan antara konsentrasi 25% ekstrak biji petai dengan konsentrasi masing-masing 50%, 75%, dan 100% terhadap pertumbuhan bakteri Pseudomonas aeruginosa.
Gambaran Kadar Pepsin pada Saliva Pasien Refluks Laringofaring di RSUP Dr. M. Djamil Padang Rahma, Mutiara Adinda; Asyari , Ade; Alioes , Yustini
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.38

Abstract

Laryngopharyngeal reflux (RFL) is a condition of tissue inflammation in the upper aerodigestive tract due to the reflux of gastric and duodenal contents, the symptoms such as post-nasal drip, globus sensation, and heartburn which decrease quality of life. RFL was diagnosed subjectively using the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). The pepsin levels in saliva that were detected by ELISA can be a sensitive and objective diagnostic marker for RFL because pepsin was only produced by chief cells in the stomach. The purpose of this study was to determine the characteristics of RFL patients based on age, sex, features of complaints in RSI, features of anatomic abnormalities in RFS, and salivary pepsin levels. This study was a descriptive observational retrospective design. From September to October 2022, this study was carried out at the Medical Record Department of RSUP Dr. M. Djamil Padang. The Lemeshow formula was used as the minimum number sampling in this study, 22% was the value of the proportion of events. The findings of this study revealed that 20 patients with RFL were tested for pepsin levels in saliva at Dr. RSUP. M. Djamil Padang, with nearly the same total number of RFL patients in each age group. The majority of RFL patients (60.0%) were female, and the most common complaint felt by RFL sufferers was post-nasal drip (90.00%). The most common anatomic abnormality was diffuse laryngeal edema (100%), and the mean pepsin levels in saliva was 15.863 ng/mL. Pepsin was found in all samples. Keywords: laringofaringeal reflux, pepsin, saliva
Co-Authors Andani Eka Putra Asyari , Ade Gestina Aliska Hasmiwati Rahma, Mutiara Adinda Ramadhan, Mario Arya Suharti , Netti