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All Journal Journal of Biomedicine and Translational Research International Journal of Health, Economics, and Social Sciences (IJHESS)
Putra, Reza Mahruzza
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Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Medicine & Pharmacology Public Health Social Sciences

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Effects of Vitamin C Supplementation on Histology of Callus Diameter and Osteoblast Number in Male Wistar Rats With Complete Femur Bone Fracture Rambe, Syahrul Ramadan; Putra, Reza Mahruzza; Rahmadhany, Heru
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.25888

Abstract

Background: The role of nutritional factors, particularly vitamin C, in bone repair has been extensively studied. However, despite this research, the specific impact of vitamin C on bone fracture healing remains unclear. While some studies suggest that vitamin C supplementation may enhance bone repair, others report no significant benefits.Objective: This study aimed to investigate the effects of different doses of vitamin C on callus formation and osteoblast proliferation in a rat femur fracture model.Methods: A post-test-only control group design was employed in this study, involving 27 male Wistar rats that were randomly divided into three groups. The first and second groups received daily intramuscular injections of vitamin C at doses of 200 mg/kg body weight (BW) and 500 mg/kg BW, respectively, following femur bone fracture and fixation. The control group did not receive vitamin C and underwent no fixation. After 14 days, all rats were euthanized, and their femur bones were histologically examined for callus diameter and osteoblast count.Results: Vitamin C supplementation significantly increased the callus diameter in rats with complete femoral fractures. Both the 200 mg and 500 mg doses proved effective, demonstrating a clear dose-response relationship. Additionally, Vitamin C significantly elevated the number of osteoblasts, which play a crucial role in bone formation. However, there was no statistically significant difference in osteoblast count between the 200 mg and 500 mg doses.Conclusion: In conclusion, vitamin C supplementation has been shown to positively influence bone fracture healing in rats by promoting an increase in callus diameter and enhancing osteoblast proliferation. This study indicates that vitamin C could serve as a beneficial adjunct therapy for facilitating bone fracture healing, particularly by improving callus formation. Physicians should consider integrating vitamin C into treatment plans for patients with fractures, using doses similar to those applied in this study, adjusted appropriately for human use.
Lower Lateral Femoral Index as a Significant Risk Factor for Non-Contact Anterior Cruciate Ligament Rupture: A Case-Control Study Ahmad Syahril Anwar; Husnul Fuad Albar; Reza Mahruzza Putra
International Journal of Health, Economics, and Social Sciences (IJHESS) Vol. 7 No. 4: October-2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v7i4.8927

Abstract

Introduction: Anterior Cruciate Ligament (ACL) injury is one of the most common knee ligament injuries, particularly in the athletic population. Anatomical risk factors, such as knee bone morphology, are thought to play a crucial role in injury susceptibility. One parameter under investigation is the Lateral Femoral Index (LFCI), which describes the shape of the lateral femoral condyle. This study aimed to analyze the difference in LFCI in patients with ACL rupture compared to normal individuals as a potential risk factor. Methods: This study employed an observational analytic design with a case-control approach, conducted at H. Adam Malik General Hospital, Medan. The sample consisted of 50 subjects divided into two groups: 25 patients with an arthroscopically confirmed diagnosis of ACL rupture (case group) and 25 healthy individuals with no history of knee injury (control group). The LFCI was measured from true lateral projection knee radiographs. An independent T-test was used for statistical analysis to compare the mean LFCI difference between the two groups. Results: The mean age of the study subjects was 30.68 ± 5.35 years. The measurements revealed that the mean LFCI in the ACL rupture group was significantly lower (0.68 ± 0.56) compared to the control group (0.74 ± 0.56). This difference was statistically significant (p < 0.001). Conclusion: There is a significant difference in the Lateral Femoral Index (LFCI) between patients with ACL rupture and normal individuals. A lower LFCI value can be considered an anatomical risk factor for ACL rupture.
Co-Authors Ahmad Syahril Anwar Husnul Fuad Albar Rahmadhany, Heru Rambe, Syahrul Ramadan