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-, Norman Ferdinal
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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Profil Metabolit Sekunder, Fenolik Total, Aktivitas Antibakteri dan Antijamur Ekstrak Daun Sungkai (Peronema canescens Jack) Dari Daerah Bengkulu dan Pariaman -, Norman Ferdinal; Fischa A., Wulandari; Suryati, Suryati
Jurnal Kimia Unand Vol. 13 No. 2 (2024): November 2024
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.13.2.8-17.2024

Abstract

Indonesian people have long recognized and utilized plants that have medicinal properties to overcome health problems. One of the medicinal plants that grow in Indonesia and is commonly used by the community is the Sungkai plant (Peronema canescens Jack). This Sungkai plant is spread across the island of Sumatra including Bengkulu and Pariaman regions. This study used methanol, ethyl acetate, and hexane extracts of sungkai leaves growing in Bengkulu and Pariaman areas for phytochemical screening, total phenolic content using the Folin-Ciocalteu method, and determination of antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria, as well as determination of Candida albicans antifungal activity using the well diffusion method. The results showed that sungkai leaf extract contained phenolics, flavonoids, saponins, steroids, and alkaloids. The methanol extract of sungkai leaves from Bengkulu and Pariaman had the highest total phenolic content of 175.3671 mg GAE/g sample and 227.7021 mg GAE/g sample, respectively. In the antibacterial activity test, the ethyl acetate extract of sungkai leaves from Bengkulu and Pariaman produced the largest inhibition zone with moderate criteria, namely 5.22 mm and 6.38 mm against Escherichia coli and Staphylococcus aureus obtained inhibition zones of 7.13 mm and 6.08 mm. The antifungal activity showed the largest inhibition zone in the ethyl acetate extract of sungkai leaves from Bengkulu and Pariaman regions, namely 5.22 mm and 6.40 mm, which are included in the moderate category.
Penentuan Kandungan Metabolit Sekunder, Fenolik Total serta Uji Aktivitas Antibakteri dan Antijamur Ekstrak Daun Sungkai (Peronema canescens Jack) di Kabupaten Agam dan Kota Padang -, Norman Ferdinal; Ningsih, Yanisa Fitria; Afrizal, Afrizal
Jurnal Kimia Unand Vol. 13 No. 1 (2024): May 2024
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.13.1.31-39.2024

Abstract

Sungkai (Peronema canescens Jack) is the traditional medicinal plants used in Indonesia. The purpose of this study was to determine the content of secondary metabolites, total phenolic content and test the antibacterial and antifungal activity of Sungkai plant leaf extract. Extraction was carried out by gradual maceration using 3 solvents with different polarity, starting from hexane, ethyl acetate and methanol. The results showed that the phytochemical profile of Sungkai leaves contained flavonoids, phenolics, saponins, triterpenoids, steroids and alkaloids. In the total phenolic test using the Folin-Ciocalteau method. The highest total phenolic content was found in the methanol extract of 195.8 mgGAE/g sample for the Padang City. The antibacterial and antifungal activity of Sungkai leaf extract were tested using the Well diffusion method. The largest diameter of the clear zone on antibacterial activity was produced in the ethyl acetate extract of the Kab. Agam with a concentration of 50% is 7 mm in Escherichia coli bacteria and 5.6 mm in Staphylococcus aureus bacteria. The highest antifungal activity against Candida albicans was produced in the ethyl acetate extract of the Padang City area of ​​6.4 mm. The ability of the extract activity is still much lower when compared to the positive control
Co-Authors - Afrizal Fischa A., Wulandari Ningsih, Yanisa Fitria Suryati Suryati