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All Journal Jurnal Periodic Jurusan Kimia UNP Jurnal Medika Farmaka Indonesian Journal of Chemical Science
Syafriadi, Riko
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Immunology & microbiology Materials Science & Nanotechnology Physics

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Molecular Docking Senyawa pada Buah Mengkudu (Morinda Citrifolia L.) terhadap Reseptor PDGFR-a sebagai Kandidat Antikanker Paru-Paru Ma'ruf, Hanif Sabawi; Ramadhan, Muhammad Arvito; Syafriadi, Riko; Suryani , Okta
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.62

Abstract

Introduction: The PDGFR-α (platelet-derived growth factor receptor alpha) receptor is one of the protein receptors implicated in the development of lung cancer by regulating proliferation, angiogenesis, and migration of cancer cells. The utilization of synthetic drugs in the treatment of cancer frequently results in the targeting of normal cells, which can lead to adverse effects in patients. Consequently, there is an imperative to engineer anticancer compounds derived from natural ingredients that exhibit a reduced incidence of adverse effects in comparison to synthetic drugs. In this study, the compounds present in noni fruit were utilized. The following section delineates the methods employed in this study. This study was conducted using a molecular docking method to identify the lowest docking score between the four most abundant compounds found in noni fruit and Gemcitabin, a positive control, against the PDGFR-α receptor. Method: This study was conducted using a molecular docking method, with the lowest docking score between the four most abundant compounds contained in noni fruit and Gemcitabin, a positive control, against the PDGFR-α receptor being of particular interest. Result: Subsequent to molecular docking, the compound demonstrating the optimal interaction among its counterparts is Nordamnacanthal, exhibiting a docking score of -6.49. This is followed by Morindone, α-Pinene, Gemcitabine, and L-Scopoletin, which demonstrate docking scores of -5.01, -4.83, -4.77, and -4.66, respectively. Conclusion: Nordamnacanthal compound exhibits a lower docking score in comparison to gemcitabine, a synthetic drug that is currently employed in the treatment of lung cancer. This finding suggests that Nordamnacanthal may be a promising candidate for anti-lung cancer drugs derived from natural compounds.
Extraction of Morinda Citrifolia Leaves Essential Oils as EGFR Inhibitor in Non-Small Cells Lung Cancer: In Silico Approach ramadhan, muhammad_arvito; Azra, Fajriah; Ma'ruf, Hanif Sabawi; Syafriadi, Riko
Indonesian Journal of Chemical Science Vol. 14 No. 2 (2025): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v14i2.19687

Abstract

Kanker paru-paru merupakan salah satu penyakit kanker dengan penderita terbanyak di dunia maupun di Indoneisa. 85% dari penyebab kanker paru-paru merupakan non-small-cell lung cancer (NSCLC) dengan mutasi gen paling banyak ditemukan pada EGFR. Ekstrak essential oils dari Morinda citrifolia telah berhasil menghambat pertumbuhan sel kanker paru-paru A549 dengan IC50 40 μg/mL. Penelitian ini bertujuan untuk menemukan kandiidat obat dari essential oils Morinda citrifolia sebagai inhibitor EGFR menggunakan pendekatan in silico melalui perangkat lunak MOE. Skrining fisikokimia dan farmakokinetika juga telah dilakukan dengan menggunakan Lipinski rule of five dan ADMET. Hasil molecular docking menunjukan 9-H-Pyridol [3, 4-b]indole dan cubenol sebagai ligan terbaik dengan masing-masing RMSD 0.790 Å dan 0.778 Å dengan masing masing nilai energi ikatan -5.992 dan -5.325 kcal.mol-1. Interaksi ligan dengan residu asam amino menujukan 9-H-Pyridol [3, 4-b]indole terdapat ikatan hidrogen pada tiga residu asam amino, yaitu Arg812, Tyr867, dan Arg865. Sementara pada cubenol memiiliki interaksi ikatan hidrofobik. Data ADMET dan Lipinski telah dicantumkan pada artikel ini untuk memberi gambaran bagaimana reaksi senyawa ligan pada tubuh.
Studi Pemanfaatan Rumput Liar Pekarangan Rumah sebagai Bahan Baku Pembuatan Ekoenzim Syafriadi, Riko; Nizar, Umar Kalmar; Stiadi, Della Rosalynna; Zuyyina, Himla; Fitriani, Fitriani; Fika, Miva Hemalia; Fadhila, Radhiatul; Syafri, Vanny Sofiana
Periodic Vol 14, No 2 (2025): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v14i2.133838

Abstract

Wild grass is a plant that grows unwanted in certain areas such as fields, gardens, agricultural land and yards. This plant is generally discarded and rarely used. Based on the composition of the materials used in ecoenzymes, fresh wild grass plants have great potential to be used as raw materials for ecoenzymes. This study aims to determine the characteristics of ecoenzymes produced using wild grass from home gardens, such as fragrant nutsedge (Cyperus aromaticus var. Elatus), virginica grass (Leersia virginica), Belulang grass (Eleusine indica), Peking grass (Agrostis stolonifera) and Ilalang (Imperata cylindrica). Wild grass with a certain composition is mixed with brown sugar and water in a ratio of 3: 1: 10 in five containers. The ecoenzyme manufacturing process is carried out for 90 days and changes in color, odor, and pH of the ecoenzyme product are observed. The results of this study indicate that the color of the five ecoenzymes produced shows a change in color to become more cloudy than the initial color of the ecoenzyme. The odor of the five ecoenzymes produced showed a change in odor to become more sour in the third month like the typical odor of weeds. Meanwhile, the pH of the ecoenzymes produced ranged from 5.8 to 7.8. The high pH of the ecoenzymes produced was caused by the low organic acid content of the ecoenzymes produced. In addition to observing the physical condition and pH of the ecoenzymes produced, qualitative testing of the nutrient content in the form of N, P and K was also carried out. Testing of the nutrient content of N, P and K carried out showed that the ecoenzymes produced from home yard weeds contained the nutrients N, P and K. These results indicate that the ecoenzymes produced can also be used as liquid organic fertilizers
Co-Authors Della Rosalynna Stiadi Fadhila, Radhiatul Fajriah Azra Fika, Miva Hemalia Fitriani Fitriani Ma'ruf, Hanif Sabawi Nizar, Umar Kalmar Ramadhan, Muhammad Arvito ramadhan, muhammad_arvito Suryani , Okta Syafri, Vanny Sofiana Zuyyina, Himla