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Vinski, Deby Susanti Pada Vinski
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Journal : journal of world science

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Advancements In Stem Cell Therapy For Pulmonary Fibrosis: A Comprehensive Review With Vinski Protocol Vinski, Deby Susanti Pada Vinski; Quintosa, Jaime Rodriguez; Ibnu Hajar, Andi; Vinski, Natasha Cinta; Kurniawan Nugroho, Andi
Journal of World Science Vol. 4 No. 9 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i9.1503

Abstract

Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by scarring of lung tissue and limited treatment options, resulting in high morbidity and poor prognosis. Mesenchymal stem cell (MSC) therapy has emerged as a promising regenerative intervention due to its potential for immunomodulation, epithelial repair, and anti-fibrotic effects. This review synthesizes current clinical and observational studies involving human participants, highlighting the safety and preliminary therapeutic benefits of MSCs in managing PF and related pulmonary conditions. Several clinical trials involving patients with idiopathic pulmonary fibrosis and COVID-19-associated lung injury demonstrated favorable safety profiles and trends toward improved pulmonary outcomes. Additionally, observational findings from the application of the Vinski Protocol at Celltech Stem Cell Centre provide further support for the regenerative capabilities of MSCs. While current human studies are encouraging, further large-scale and long-term clinical trials are essential to validate the efficacy of MSC therapy and establish standardized treatment protocols for PF.
From Vitality to Security: Stem Cells and Testosterone Supporting Health and National Defense with the Vinski Protocol Vinski, Deby Susanti Pada Vinski; Vinski, Natasha Cinta; Trofimova, Svetlana; Kurniawan Nugroho, Andi; Pujowaskito, Prihati
Journal of World Science Vol. 4 No. 11 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i11.1589

Abstract

The vitality and health of a nation’s citizens, especially its emergency and defense forces, are inseparable from national security. Regenerative and hormonal medicine is an exciting new field in performance medicine. This Phase 1 clinical trial assesses the safety and initial effectiveness of the Vinski Protocol, an innovative therapy involving umbilical cord-derived mesenchymal stem cells (UC-MSCs) in conjunction with testosterone optimization therapy. Twenty-five healthy men, aged 25-45 years, received three intravenous infusions of UC-MSCs and weekly testosterone cypionate for 12 weeks. Primary outcomes measured safety through adverse event monitoring and clinical laboratory profiles, and secondary outcomes were serum testosterone change, VO2 max, body composition, inflammatory markers (C-reactive protein [CRP] and interleukin 6 [IL-6]), and subjective vitality. The protocol was well-tolerated with no serious adverse events; 12% of subjects reported mild fatigue. Statistically significant changes were noted in testosterone level (+215 ng/dL, p < 0.01), lean mass (+2.1 kg, p < 0.05), VO2 max (+11.8%, p < 0.05), and decreases in CRP and IL-6 (p < 0.05). Energy and mental clarity also improved in subjects. These findings provide evidence for the feasibility and potential effectiveness of the Vinski Protocol as a dual regenerative-hormonal approach to increasing individual vitality and overall health resilience.
Integrative Regeneration of Articular Cartilage Using Mesenchymal Stem Cells and Gene Therapy: A Precision Medicine Approach Vinski, Deby Susanti Pada Vinski; Vinski, Natasha Cinta; Nugroho, Andi Kurniawan; Kusumo, Sunaryo; Griffin, Darren Karl
Journal of World Science Vol. 5 No. 1 (2026): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v5i1.1607

Abstract

Osteoarthritis (OA) is a prevalent and debilitating chronic condition that primarily affects the articular cartilage, leading to pain, stiffness, and loss of function. Despite significant advancements in understanding its pathophysiology, an effective cure remains elusive. This paper explores the integrative regeneration of articular cartilage using mesenchymal stem cells (MSCs) combined with gene therapy as a precision medicine approach. MSCs are particularly promising due to their chondrogenic potential and ability to repair damaged cartilage. However, the inflammatory environment in OA often limits the survival of MSCs. Gene therapy emerges as a solution to modulate this environment, enhancing the regenerative capacity of MSCs. This study highlights the synergy between MSC therapy and gene therapy in promoting cartilage repair, focusing on the Vinski protocol. By targeting the joint's microenvironment and using MSCs in combination with gene therapy, this integrated approach aims to provide a more effective treatment for OA. The application of gene therapy is expected to not only sustain MSC survival but also improve their therapeutic effects, making this method a promising avenue for OA treatment.
Mesenchymal Stem Cell Combination Therapy Via Intravenous and C-Arm– Guided Spinal Delivery: A Systematic Review and Meta-Analytic Framework For Neurological and Functional Recovery Vinski, Deby Susanti Pada Vinski; Vinski, Natasha Cinta; Kusumo, Sunaryo; Siagian, Carles
Journal of World Science Vol. 5 No. 4 (2026): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v5i4.1662

Abstract

Mesenchymal stem/stromal cells (MSCs) have emerged as a promising therapeutic platform for neurological and spinal disorders due to their immunomodulatory, trophic, anti-inflammatory, and regenerative properties. Clinical studies have evaluated MSCs via intravenous (IV) and intrathecal (IT) or intraspinal routes, yet the translational rationale for combining systemic and targeted spinal delivery remains insufficiently synthesized. C-arm-guided spinal administration may enhance procedural precision, optimize cerebrospinal or peri-spinal targeting, and potentially improve regional bioavailability. This review aimed to examine the clinical rationale, safety profile, and therapeutic potential of combined MSC administration through IV and C-arm-guided spinal routes, focusing on neurological recovery, pain, functional independence, and spinal health-related performance. The study was structured as a PRISMA 2020-aligned systematic review with a meta-analytic framework. Evidence was synthesized from comparative clinical literature on MSC therapy in spinal cord injury, stroke sequelae, multiple sclerosis, amyotrophic lateral sclerosis, and related disorders. Risk of bias was assessed using RoB 2 and ROBINS-I. A route-specific quantitative safety meta-analysis was performed using extractable data on treatment-related serious adverse events. From 2,308 identified records, 9 studies were included in the qualitative synthesis and 6 primary studies in the safety meta-analysis. Evidence indicates that IT delivery is feasible and generally safe, with no consistent signal of serious procedure-related toxicity. In spinal cord injury, IT MSC delivery demonstrated encouraging neurological improvement signals. IV delivery offers broader systemic immunomodulation. In the pooled safety analysis, treatment-related serious adverse events were rare, with estimates approaching zero and no detectable heterogeneity.
Co-Authors Andi Kurniawan Nugroho Carles Siagian, Carles Griffin, Darren Karl Ibnu Hajar, Andi Kurniawan Nugroho, Andi Kusumo, Sunaryo Pujowaskito, Prihati Quintosa, Jaime Rodriguez Trofimova, Svetlana Vinski, Natasha Cinta