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All Journal GANESHA MEDICINA JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Sosial dan Sains
Okaniawan, Putu Enrico Pramana
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Astronomy Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Physics Public Health

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PENURUNAN FUNGSI KOGNITIF AKIBAT DIABETES MELITUS Okaniawan, Putu Enrico Pramana; Agustini, Ni Nyoman Mestri
Ganesha Medicina Vol. 1 No. 1 (2021)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.174 KB) | DOI: 10.23887/gm.v1i1.31708

Abstract

Penyakit diabetes melitus merupakan suatu golongan penyakit sistemik yang merupakan penyakit yang dapat mempengaruhi seluruh tubuh. Berdasarkan studi neuroimaging dan neuropatologis, diabetes melitus rupanya terlibat dalam proses degenerasi saraf. Etiologi dari penurunan kemampuan kognitif ialah beberapa penyakit degeneratif seperti alzheimer. Faktor resiko dari penurunan kemampuan kognitif akibat diabetes ialah kejadian berulang episode hipoglikemia, pasien dengan manifestasi mikrovaskular (seperti diabetic retinopathy) atau penyakit makrovaskular (seperti infark atau stroke miokard), resistensi insulin, peradangan, dan depresi. Penyakit ini dapat mempengaruhi kognitif melalui gangguan pada pembuluh darah otak. Efek DMT1 terhadap gangguan kognitif dapat terjadi pada anak serta efek DMT2 dapat meningkatkan resiko gangguan kognitif ringan menjadi demensia. Saat ini belum ada teknik diagnosis dan tatalaksana yang terbaik, namun sejumlah penelitian klinis telah menyoroti potensi Traditional Chinese Medicine dalam proses tatalaksana ini Kata kunci: Diabetes Melitus, Kognitif, Memori
Predictors of Length of Stay in Dengue Fever: A Multicenter Study Khoiruddin, Mukhammad Arif Hadi; Okaniawan, Putu Enrico Pramana; Suarlin, Ketut Ayu Oktavyanti; Nugrah, Putu Arya; Suciawan, Nyoman
Jurnal sosial dan sains Vol. 5 No. 11 (2025): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v5i11.32582

Abstract

Dengue fever (DF) is mostly common in certain geographical areas, such as Indonesia, where it continues to be public health problem due to its nature as a viral infection spread through mosquitos. The focus of this study is to assess the factors affecting length of hospital stay (LOS) among DF patients in Buleleng Regency. Between July and December 2024, a cross-sectional investigation was carried out at many hospitals, retrieving the medical records of 940 DF patients. The Spearman test was used in statistical analysis to examine the association between LOS and clinical indicators. The majority of patients (60.96%) were youngsters, 95.5% were admitted to the paediatric ward, and their recovery rate (99.89%) and mortality rate (0.11%) were also high. LOS was significantly associated with leukocyte levels, fever duration, and severity of the disease (p<0.05). However, age, gender, hematocrit, and platelet levels did not show significant association with LOS (p>0.05). This reveals that leukocyte count, duration of fever, and severity of DF contribute in determining hospital stay duration while discharge criteria as such degree of anemia and thrombocytopenia do not appear to be reliable predictors. It is suggested that there is a gap in literature that needs to be looked into regarding the genetic clinical determinants of LOS patients with DF needs further evaluation.
Cilostazol or clopidogrel? Comparative evidence on bleeding risk, stroke recurrence, and mortality in ischemic stroke – A systematic review and meta-analysis Okaniawan, Kadek Kovaleviska; Maheswari, Ni Putu Devi; Okaniawan, Putu Enrico Pramana; Agustini, Ni Nyoman Mestri; Sastri, Ni Luh Putu Pranena
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 2, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss2.art12

Abstract

Ischemic stroke remains a major contributor to global mortality and long-term disability, with antiplatelet therapy representing a fundamental strategy for secondary prevention. Cilostazol and clopidogrel are widely utilized antiplatelet agents; however, existing comparative evidence on their safety and efficacy, particularly regarding bleeding risk, stroke recurrence, and mortality, is inconsistent. This systematic review and meta-analysis aim to evaluate and compare the efficacy and safety of cilostazol versus clopidogrel in patients with ischemic stroke. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We conducted a comprehensive literature search across PubMed, Scopus, and Google Scholar up to September 2025. Eligible studies included randomized controlled trials and retrospective cohort studies directly comparing cilostazol and clopidogrel in adult patients with ischemic stroke. Multiple reviewers independently extracted data and selected studies using Covidence software to ensure consistency. We assessed risk of bias using the RoB 2.0 and ROBINS-I tools. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using Mantel–Haenszel methods. Eight studies comprising 8,249 participants were included in the analysis. Cilostazol was associated with lower risks of hemorrhagic complications (RR 0.77; 95% CI: 0.58–1.03) and mortality (RR 0.86; 95% CI: 0.70–1.04), although neither difference was statistically significant. No significant differences were identified between cilostazol and clopidogrel in recurrent ischemic stroke events or functional outcomes. Overall, both agents demonstrated comparable efficacy and safety profiles, supporting individualized treatment decisions based on clinical characteristics, bleeding risk, and comorbidities.
Co-Authors Khoiruddin, Mukhammad Arif Hadi Maheswari, Ni Putu Devi Ni Luh Putu Pranena Sastri, Ni Luh Putu Pranena Ni Nyoman Mestri Agustini Nugrah, Putu Arya Okaniawan, Kadek Kovaleviska Suarlin, Ketut Ayu Oktavyanti Suciawan, Nyoman