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All Journal Widya Kesehatan Svāsthya: Trends in General Medicine and Public Health
Dewi, Ni Luh Made Noviana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Ethnomedicine di Indonesia: Perspektif tradisional hingga lanskap modern: Ethnomedicine in Indonesia: From traditional perspectives to the modern landscape Adnyana , I Made Dwi Mertha; Jenar, Putut Dewantha; Suniartini, Ketut; Dewi, Ni Luh Made Noviana; Sugiarta, Ketut Merdana; Sridana, I Nyoman
Widya Kesehatan Vol. 7 No. 1 (2025): Widya Kesehatan
Publisher : Universitas Hindu Indonesia (UNHI) Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/s1dc9743

Abstract

Latar Belakang: Paradigma kesehatan tradisional Indonesia mengalami transformasi dari praktik berbasis adat-istiadat menuju pengobatan berdasarkan bukti empiris. Ethnomedicine berkembang sebagai integrasi pengetahuan, praktik, dan kepercayaan turun-temurun yang berakar dari antropologi medis, mencakup konsep sehat-sakit, pencegahan, dan penyembuhan dari perspektif budaya lokal. Tujuan: Menganalisis perkembangan ethnomedicine di Indonesia dari perspektif tradisional hingga lanskap modern, mengevaluasi potensi Indonesia sebagai pusat ethnomedicine dunia, dan mengidentifikasi tantangan serta peluang integrasi pengobatan tradisional dengan sistem kesehatan kontemporer. Metode: Analisis bibliometrik terhadap 2.783 artikel publikasi menggunakan kata kunci "Ethnomedicine", "Traditional medicine", "community medicine", dan "Indonesia" periode 1971-2024. Penelusuran literatur dilakukan untuk memetakan tren penelitian, kluster riset, dan densitas pengembangan ethnomedicine di Indonesia. Hasil: Terdapat 67.804 artikel ilmiah yang memberikan informasi klinis dan pra-klinis tentang kesehatan tradisional. Bali dan Sumatera Utara menunjukkan fokus tinggi dalam pengembangan obat bahan alam. Kluster riset difokuskan pada "drug", "jamu", "local knowledge", "traditional healer", dan "health care". Visualisasi tren menunjukkan penguatan elemen ethnomedicine dengan dominasi penelitian berbasis pengetahuan lokal dan pengembangan produk kesehatan komplementer. Kesimpulan: Indonesia memiliki potensi besar menjadi pusat ethnomedicine dunia dengan dukungan 25.000-30.000 spesies tumbuhan obat dan 300-700 etnis. Integrasi pengobatan tradisional-modern mencerminkan lanskap kesehatan dinamis. Keberlanjutan ethnomedicine memerlukan penguatan regulasi, fasilitas riset, kolaborasi global, dan pelestarian pengetahuan tradisional melalui digitalisasi dan program pendidikan berbasis budaya lokal.
Dual impact analysis of GSTT1 polymorphisms on the metformin response and cardiovascular risk: A novel integrated approach in type 2 diabetes mellitus management Dewi, Ni Luh Made Noviana
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 1 (2025): January 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i1.76

Abstract

Although genetic variations in glutathione S-transferase (GST) have been linked to type 2 diabetes mellitus (T2DM), the relationships among GSTT1 polymorphisms, metformin effectiveness, and cardiovascular risk remain unclear. This study investigated the association between the GSTT1 null genotype and the metformin monotherapy response while simultaneously assessing its impact on atherosclerotic cardiovascular disease risk. This case-control study examined 84 T2DM patients aged 30-70 years, categorized into metformin therapy responders and nonresponders. This study employed multiplex PCR for GSTT1 genotyping and utilized the pooled cohort equation for cardiovascular risk assessment, offering a comprehensive analysis of both genetic and clinical parameters. GSTT1 genetic variations were not significantly associated with metformin response (odds ratio [OR] 1.773, p=0.306) or cardiovascular risk (OR 1.086, 95% CI: 0.46-2.56, p=1.000). The analysis revealed distinct patterns in clinical parameters between the GSTT1 null and wild-type genotypes, particularly in terms of glycemic control indicators and lipid profiles, although these differences did not reach statistical significance. This study presents a novel approach by simultaneously examining both the therapeutic response and cardiovascular risk in relation to GSTT1 polymorphisms, distinguishing it from previous studies that typically focused on either aspect in isolation. These findings suggest that while genetic variations in GSTT1 may influence metabolic parameters, their direct impact on metformin effectiveness and cardiovascular risk may be more complex than previously thought.
Co-Authors Adnyana , I Made Dwi Mertha Putut Dewantha Jenar Sridana, I Nyoman Sugiarta, Ketut Merdana Suniartini, Ketut