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All Journal Research of Service Administration Health and Sains Healthys BIOCITY: Journal of Pharmacy Bioscience and Clinical Community Lombok Medical Journal
Jayawardhana, I Ketut Wisnuaji
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health

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Komorbid Diabetes Melitus pada Pasien COVID-19 Meningkatkan Keparahan: Sebuah Tinjauan Pustaka Jayawardhana, I Ketut Wisnuaji; Cut Warnaini
Lombok Medical Journal Vol. 2 No. 2 (2023): Lombok Medical Journal Volume 2 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i1.978

Abstract

Bahasa Indonesia : Abstrak Diabetes mellitus salah satu komorbid paling banyak pada pasien COVID-19. Komorbid DM meningkatkan keparahan pasien COVID-19. Penulis ingin mengetahui mengapa komorbid DM dapat meningkatkan keparahan pasien COVID-19. Metode yang digunakan adalah mengumpulkan literatur tahun 2020-2021 yang relevan dengan topik. Literatur dicari melalui mesin pencari PubMed dan Google Scholar dengan kata kunci pencarian Severity AND COVID-19 OR 2019-nCov OR "Coronavirus Disease 2019" AND Comorbid AND "Diabetes mellitus". Beberapa penelitian menyatakan bahwa pasien COVID-19 dengan komorbid diabetes mellitus meningkatkan keparahan yang berujung dengan kematian. Infeksi virus dengan kondisi hiperglikemia memudahkan virus menempel ke sel inang akibat meningkatnya reseptor ACE2. Imunitas seluler menurun akibat terganggunya fungsi sel T. Mediator inflamasi meningkat dan menyebakan terjadinya badai sitokin sehingga rentan mengalami ARDS. Komplikasi DM yang timbul bersamaan dengan infeksi virus menambah keparahan pasien. Kata Kunci : COVID-19, Diabetes Mellitus, Keparahan Bahasa Inggris : Abstract Diabetes mellitus is one of the most common comorbidities in COVID-19 patients. Comorbid DM increases the severity of COVID-19 patients. The author wants to know why comorbid DM can increase the severity of COVID-19 patients. The method used is to collect literature for 2020-2021 that is relevant to the topic. Literature was searched through the search engines PubMed and Google Scholar with keywords Severity AND COVID-19 OR 2019-nCov OR "Coronavirus Disease 2019" AND Comorbid AND "Diabetes mellitus". Several studies have shown that COVID-19 patients with comorbid diabetes mellitus have an increased severity that leads to death. Viral infections with hyperglycemic conditions make it easier for the virus to attach to host cells due to increased ACE2 receptors. Cellular immunity decreases due to disruption of T cell function. Inflammatory mediators increase and cause a cytokine storm so that they are susceptible to ARDS. Complications of DM that occur together with viral infection add to the severity of the patient. Keyword : COVID-19, Diabetes Mellitus, Severity
Anemia Megaloblastik: Sebuah Tinjauan Pustaka Jayawardhana, I Ketut Wisnuaji; Kresnapati, I Nyoman Bagus Aji
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol. 1 No. 1 (2022): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v1i1.2422

Abstract

Anemia megaloblastik merupakan anemia yang ditandai dengan membesarnya eritroblast di sumsum tulang sehingga menganggu pematangan inti sel dan pembelahan sel eritrosit. Kelainan utamanya disebabakan karena defisiensi vitamin B-12 dan asam folat sehingga sintesis DNA terganggu. Diagnosis anemia megaloblastik dilakukan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pengobatannya dilakukan berdasarkan etiologi yang mendasari. Semakin cepat didiagnosis, prognosisnya akan semakin baik. Penting untuk mengenali, mencegah, dan mengobati anemia megaloblastik.
Komorbid Diabetes Melitus pada Pasien COVID-19 Meningkatkan Keparahan: Sebuah Tinjauan Pustaka Jayawardhana, I Ketut Wisnuaji; Cut Warnaini
Lombok Medical Journal Vol. 2 No. 2 (2023): Lombok Medical Journal Volume 2 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i1.978

Abstract

Bahasa Indonesia : Abstrak Diabetes mellitus salah satu komorbid paling banyak pada pasien COVID-19. Komorbid DM meningkatkan keparahan pasien COVID-19. Penulis ingin mengetahui mengapa komorbid DM dapat meningkatkan keparahan pasien COVID-19. Metode yang digunakan adalah mengumpulkan literatur tahun 2020-2021 yang relevan dengan topik. Literatur dicari melalui mesin pencari PubMed dan Google Scholar dengan kata kunci pencarian Severity AND COVID-19 OR 2019-nCov OR "Coronavirus Disease 2019" AND Comorbid AND "Diabetes mellitus". Beberapa penelitian menyatakan bahwa pasien COVID-19 dengan komorbid diabetes mellitus meningkatkan keparahan yang berujung dengan kematian. Infeksi virus dengan kondisi hiperglikemia memudahkan virus menempel ke sel inang akibat meningkatnya reseptor ACE2. Imunitas seluler menurun akibat terganggunya fungsi sel T. Mediator inflamasi meningkat dan menyebakan terjadinya badai sitokin sehingga rentan mengalami ARDS. Komplikasi DM yang timbul bersamaan dengan infeksi virus menambah keparahan pasien. Kata Kunci : COVID-19, Diabetes Mellitus, Keparahan Bahasa Inggris : Abstract Diabetes mellitus is one of the most common comorbidities in COVID-19 patients. Comorbid DM increases the severity of COVID-19 patients. The author wants to know why comorbid DM can increase the severity of COVID-19 patients. The method used is to collect literature for 2020-2021 that is relevant to the topic. Literature was searched through the search engines PubMed and Google Scholar with keywords Severity AND COVID-19 OR 2019-nCov OR "Coronavirus Disease 2019" AND Comorbid AND "Diabetes mellitus". Several studies have shown that COVID-19 patients with comorbid diabetes mellitus have an increased severity that leads to death. Viral infections with hyperglycemic conditions make it easier for the virus to attach to host cells due to increased ACE2 receptors. Cellular immunity decreases due to disruption of T cell function. Inflammatory mediators increase and cause a cytokine storm so that they are susceptible to ARDS. Complications of DM that occur together with viral infection add to the severity of the patient. Keyword : COVID-19, Diabetes Mellitus, Severity
The Role of Microglia and Astrocytes in the Neuroinflammation Process in Acute Ischaemic Stroke Qomala, Dianing Aluh; Jayawardhana, I Ketut Wisnuaji; Abtartu, Lalu Hizrian; Rabsanjani, Rabsanjani; Hunaifi, Ilsa
Research of Service Administration Health and Sains Healthys Vol 6, No 2 (2025): Research of Service Administration Health and Sains Healthys (Desember)
Publisher : Lembaga Penelitian dan Pendidikan (LPP) Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/rehat.v6i2.9784

Abstract

Acute ischemic stroke triggers a complex neuroinflammatory response involving resident glial cells, particularly microglia and astrocytes. Microglia rapidly activate following ischemia and polarize into two main phenotypes: the pro-inflammatory M1 phenotype, which exacerbates neuronal damage through the release of cytokines like TNF-α, IL-1β, and reactive oxygen species (ROS), and the anti-inflammatory M2 phenotype, which promotes tissue repair via IL-10 and IL-4 secretion. Astrocytes also play a dual role: in the acute phase, they exert neuroprotective effects by regulating glutamate homeostasis, producing antioxidants (e.g., glutathione and superoxide dismutase), and supporting neurogenesis and angiogenesis; however, in the chronic phase, reactive astrocytes contribute to glial scar formation, which inhibits axonal regeneration. The dynamic interplay between microglia and astrocytes critically shapes the neuroinflammatory milieu—determining whether the response is protective or detrimental. Understanding these dual roles offers promising avenues for developing neuroprotective therapies targeting neuroinflammation after acute ischemic stroke.
Co-Authors Abtartu, Lalu Hizrian Cut Warnaini Ilsa Hunaifi, Ilsa Kresnapati, I Nyoman Bagus Aji Qomala, Dianing Aluh Rabsanjani, Rabsanjani