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Sembiring , Novitaria Br
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Identifikasi Glibenklamid Pada Jamu Kencing Manis Yang Beredar di Medan Johor Andriani, Vina; Sembiring , Novitaria Br; Bangar, Roy Indrianto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.889

Abstract

Background: The increasing use of traditional herbal medicine (jamu) for diabetes treatment in the community has been accompanied by a rise in counterfeiting practices, particularly through the addition of synthetic drugs such as glibenclamide (C₂₃H₂₈ClN₃O₅S) to enhance efficacy and sales. This poses potential health risks, thereby necessitating strict monitoring of circulating herbal products. Objective: This study aims to identify the presence of glibenclamide in three samples of antidiabetic jamu available in Medan Johor using Fourier-Transform Infrared Spectroscopy (FTIR). Method: Identification was carried out by comparing the FTIR spectra of the samples (wavenumber range 650–4000 cm⁻¹) with that of the BPFI glibenclamide standard. The characteristic functional groups of glibenclamide used as reference were 3369.5 cm⁻¹ (Amide N–H Stretching), 1714.6 cm⁻¹ (C=O Stretching), and 1155.5 cm⁻¹ (S=O Stretching). Results: The analysis showed that none of the three samples (A2, A3, A4) exhibited absorption peaks corresponding to the critical wavenumbers of glibenclamide. Therefore, the tested samples were declared free from the pharmaceutical chemical substance (PCS) glibenclamide. Conclusion: These findings indicate that the three jamu products are safe for consumption when used as directed. However, routine surveillance by the National Agency of Drug and Food Control (BPOM) remains essential to ensure the safety of herbal products on the market. Further studies using more sensitive methods such as UV-Vis spectrophotometry are recommended to verify these results.
Formulasi Dan Uji Aktivitas Gel Fraksi Aktif Biji Kopi Robusta (Coffea Canephora L.) terhadap Stapylococcus aureus sebagai Terapi Ulkus Diabetik Tarigan, Putri Diana Br; Sembiring , Novitaria Br; Yunus , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1334

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Introduction: Diabetes mellitus is one of the health problems that deserves attention worldwide. Diabetes mellitus causes complications in various organs of the body. One of the complications of diabetes mellitus for sufferers is the appearance of diabetic wounds or gangrene and ulcers that cause susceptibility to bacterial infections. One of the bacteria that causes diabetic wounds is Staphylococcus aureus, which can be found on the skin surface as normal flora. Objective: This study aims to formulate the active fraction of robusta coffee beans (Coffea Canephora L.) into a gel preparation and evaluate its antibacterial activity against Staphylococcus aureus. Methods: This experimental study involved the extraction of robusta coffee beans with 96% ethanol maceration, phytochemical screening, and fractionation using n-hexane, ethyl acetate, and water solvents. Furthermore, the fraction results were tested using the disk diffusion method to determine the active fraction in robusta coffee beans to be formulated into gel preparations with concentrations of 12.5%, 25%, and 50% and physical stability tests were conducted. Based on the results of the study, the water fraction and gel preparation of robusta coffee beans showed inhibition of antibacterial activity against Staphylococcus aureus, with the greatest inhibition at a concentration of 50%. Therefore, the active fraction gel of robusta coffee beans has the potential as a treatment for diabetic wounds. Organoleptic testing of the gel showed a distinctive honey smell, brown color, and a slightly acidic pH of formula 1.
Uji Total Flavonoid Dan Aktivitas Antioksidan Fraksi Aktif Biji Kopi Robusta (Coffea canephora L. ) Sebagai Diabetik Ulcer Perangin-Angin, Elpina Br; Sembiring , Novitaria Br; Kaban , Vera Estefania
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1342

Abstract

Diabetes mellitus is a chronic metabolic disease frequently accompanied by serious complications, including diabetic foot ulcers, which require comprehensive management and supportive therapies derived from natural sources. Robusta coffee beans (Coffea canephora L.) contain various bioactive compounds with potential antioxidant properties that may support wound healing. This study aimed to determine the total flavonoid content and evaluate the antioxidant activity of active fractions of robusta coffee beans. An experimental laboratory design was applied, involving maceration using 96% ethanol followed by solvent fractionation with n-hexane, ethyl acetate, and water. Total flavonoid content was determined using ultraviolet–visible spectrophotometry with quercetin as the reference standard, while antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl assay with vitamin C as a comparator. The results showed an extraction yield of 14.33%, and phytochemical screening confirmed the presence of alkaloids, flavonoids, phenolic or tannin compounds, saponins, and triterpenoids. All fractions exhibited very strong antioxidant activity, with the ethyl acetate fraction demonstrating the highest activity, comparable to vitamin C, whereas the highest total flavonoid content was observed in the n-hexane fraction. In conclusion, robusta coffee beans possess strong potential as a natural antioxidant source and may be developed as a supportive alternative therapy for diabetic wound management.
Co-Authors Bangar, Roy Indrianto Kaban , Vera Estefania Perangin-Angin, Elpina Br Tarigan, Putri Diana Br vina andriani Yunus , Muhammad