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All Journal JOPS (Journal Of Pharmacy and Science) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Current Research on Biosciences and Biotechnology Jurnal Buana Farma Narra J JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Kesehatan Masyarakat Jurnal Sains dan Teknologi Jurnal Kesehatan Farmasi Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal International Journal of Health, Engineering and Technology MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Journal of Pharmaceutical and Sciences. Jurnal Sains Student Research Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Jurnal Sains Farmasi dan Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Roy Indrianto Bangar S
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Isolation of α-glucosidase enzyme inhibitor from titanus (Leea aequata L.) Bangar, Roy; Ningsih, Kurnia Nastira; Kartasasmita, Rahmana Emran; Insanu, Muhamad
Current Research on Biosciences and Biotechnology Vol. 6 No. 1 (2024)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2024.6.1/XCGSRS5W

Abstract

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels. Indonesia was ranked fourth globally, with over 12 million people suffering from diabetes. Natural-based drugs can be an alternative for treating diabetes with fewer side effects and are expected to be more economical than conventional drugs. One of the plant families used to reduce blood glucose levels is the Vitaceae family. One of the Vitaceae species currently used for traditional medicine is Leea aequata. This study aimed to isolate active compounds with α-glucosidase inhibitor activity from titanus plant. This study began with collecting leaf, fruit, and stem samples from titanus plants that grow in North Sumatra. The extraction method used was maceration using ethanol 96%. The isolation stage started with fractionation, followed by purification with column chromatography, in which TLC monitored for each process. α-glucosidase in testing was carried out on extracts, fractions, and isolates using a reagent Multiscan microplate reader at 400 nm. Compound identification was done using spectrodensitometry and 1H-NMR spectroscopy. The IC50 value of the ethyl acetate fraction (2.4±0.02 µg/mL) was higher than the ethanol extract (8.96 ± 0.44 µg/mL), n-hexane fraction (21±0.61 µg/mL), and water fraction (16.96 ± 0.38 µg/mL), so it was continued to the isolation stage. The isolated compound was characterized as 3,3′,4′,5,7-Pentahydroxyflavone 3-rhamnoside (quercitrin) with the IC50 was 12.25 ± 0.2 µg/mL.
Synergistic mechanism of Phyllanthus emblica extract and tetracycline against multidrug-resistant Acinetobacter baumannii Nasution, Haris M.; Yulyana, Ana; Utama, Rezza F.; Bangar, Roy I.; Kaban, Vera E.; Daulay, Wardiyah; Astyka, Ririn; Lubis, Muhammad F.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1939

Abstract

The rising incidence of multidrug-resistant (MDR) Acinetobacter baumannii infections underscores the urgent need for novel antimicrobial strategies. The aim of this study was to investigate the synergistic effects between a polyphenol-rich extract from Phyllanthus emblica fruit and tetracycline against MDR A. baumannii strains. The extraction process was optimized using the Box-Behnken design approach to maximize the total phenolic content (TPC) of the P. emblica extract. Key variables, including ethanol concentration, extraction time, and solid-to-liquid ratio (w/v), were determined through single-factor experiments. The antimicrobial activity of the extract, both alone and in combination with tetracycline, was evaluated against A. baumannii. Mechanistic studies focusing on bacterial lysis and efflux pump inhibition were conducted to assess the extract's effects and its combined potential with tetracycline. The Box-Behnken design successfully optimized the extraction conditions, yielding the highest TPC at 68.92% ethanol concentration, 1.85 days of extraction time, and a 1:9.58 w/v ratio. The predicted and experimentally verified TPC values of the extract were 129.19 and 130.76±2.46 mg GAE/g samples, respectively, with no significant difference (p>0.05). The extract contained several phenolic compounds identified using liquid chromatography–high-resolution mass spectrometry (LC-HRMS). It exhibited antimicrobial activity against MDR Acinetobacter baumannii, either alone or in combination with tetracycline. The combination demonstrated a synergistic effect against MDR A. baumannii, with a fractional inhibitory concentration index (FICI) of 0.37. Moreover, the combination showed superior bacteriolytic effects against MDR A. baumannii cells, as evidenced by increased release of nucleic acid components and membrane destabilization, compared to the extract or tetracycline alone (p<0.0001 for all comparisons). Additionally, the combination significantly enhanced the efflux pump inhibition effect compared to the extract or tetracycline alone (p<0.05 for both). These findings support the potential use of polyphenol-rich P. emblica extracts as adjuncts to conventional antibiotics in treating drug-resistant bacterial infections.
Antioxidant Activity Test of The Aqueous Fraction of Tetanus Leaves (Leea aequata L.) Using The DPPH Method Siregar, Nurhakiki; Bangar, Roy Indrianto; Kaban, Vera Estefania; Simanjuntak, Nerly Juli Pranita
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.85

Abstract

Antioxidants play a crucial role in neutralizing free radicals, thereby helping to prevent cell damage and maintain overall health. This study aims to evaluate the antioxidant activity of the aqueous fraction of Tetanus (Leea aequata L.) leaf extract using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The extraction process was carried out through maceration using ethanol as a solvent, followed by aqueous fractionation. Antioxidant activity was measured based on the extract’s ability to scavenge DPPH free radicals, expressed as the IC₅₀ value. The results showed that the aqueous fraction of Tetanus leaf extract exhibited high antioxidant activity, with an IC₅₀ value of 30.23 mg/L. The total phenolic and flavonoid contents in the aqueous fraction were 460.70 mg GAE/100g and 12,621.14 mg QE/100g, respectively. These findings align with pre vious studies indicating that the ethanolic extract of Leea angulata leaves also possesses strong antioxidant activity with a similar IC₅₀ value. Therefore, the aqueous fraction of Tetanus leaf extract has the potential to be an effective natural antioxidant source and can be further developed as a raw material for health supplements or pharmaceutical products.
Efficacy Test of Tetanus Leaf (Leea aequata L.) Ethanol Extract against Bacteria (Pseudomonas aeruginosa) Lumban Gaol, Irma Yohana; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.86

Abstract

Antibiotic-resistant nosocomial infections are caused by the opportunistic bacterium Pseudomonas aeruginosa. The purpose of this study is to use the disc diffusion method to assess the antibacterial efficacy of Tetanus (Leea aequata L.) leaf ethanol extract against Pseudomonas aeruginosa. The antibacterial activity was evaluated at 25%, 50%, and 75% concentrations after the leaves were extracted by maceration with 96% ethanol. The findings indicated that the antibacterial activity was depending on concentration, with respective minimum inhibition level measuring 12.97 mm, 16.7 mm, and 21.06 mm. The negative control (DMSO) displayed no inhibition zone, but the positive control (gentamicin) displayed KHM measuring 25.03 mm. The data distribution did not differ significantly, according to statistical analysis (p > 0.05). Bioactive substances that can harm bacterial cell structures, including flavonoids, alkaloids, tannins, and saponins, were thought to be responsible for this antibacterial action. According to these results, tetanus leaf extract may be used as a natural antibacterial agent and as a substitute for antibiotics in the treatment of Pseudomonas aeruginosa infections
Formulation and Evaluation of Tetanus Leaf (Leea aequata L.) Ethanol Extract on Tablet Preparation using Wet Granulation Method Ningsih, Wulan Seppia; Bangar, Roy Indrianto; Kaban, Vera Estefania; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.87

Abstract

Degenerative diseases are currently widely suffered, especially in Indonesian society, as many as 30% of the population is detected with degenerative diseases. One alternative treatment that is widely consumed by Indonesian society is herbal or traditional medicine, one of the plants that is widely consumed by society, especially in Indonesia, namely Tetanus Leea Aequata L leaves. These leaves are often found, especially in the Karo area. The purpose of this study was to use ethanol extract of tetanus Leea Aequata leaves as tablets using the wet granulation method. The content contained in the leaves, such as Flavonoids, can be used as an alternative medicine to treat degenerative diseases by using a comparison of muchilago amyli used as a binder, namely f1 20%, f2 10% and F3 5% based on this study, a formula was obtained that can be used to make tablets, namely formula 1 20% muchilago amyli
Antioxidant Activity Test of The Ethyl Acetate Fraction of Tetanus Leaf (Leea aequata L.) Using The DPPH Method Waruwu, Loice Desy Krisna Yanti; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.88

Abstract

Degenerative diseases, such as diabetes, stroke, and cancer, are increasingly common in modern society, with free radicals as one of the main causes. Both natural and artificial sources of antioxidants are available. However, natural antioxidants are a better choice due to concerns over the negative effects of synthetic antioxidants. This study aims to evaluate the antioxidant activity of ethanol extract from titanus (leea aequata L.) leaves using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. titanus leaves are known to contain secondary metabolites that have potential as antioxidants, including flavonoids and phenols. This type of research is an experimental method. The extraction process was carried out by maceration method using 96% ethanol, followed by fractionation using solvents with different polarities to obtain ethyl acetate fraction. The results showed that the ethyl acetate fraction showed the ability as a free radical antidote with an IC50 value of 11.309 ppm, which indicates significant antioxidant activity. These results indicate that titanus leaf extract has the potential to be used as a source of natural antioxidants in the prevention of degenerative diseases.
Antioxidant Activity Test of Titanus (Leea aequata L) Leaf Extract with DPPH Method Sihotang, Nurhanifah; Bangar, Roy Indrianto; Kaban, Vera Estefania; Br Sembiring, Novitaria; Harahap, Daimah Wirdatus Sanaun
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.90

Abstract

Free radicals play an important role in oxidative stress, which can lead to a number of degenerative diseases, including heart disease, cancer and premature aging. Natural and artificial ingredients can be used to make antioxidants. The use of synthetic antioxidants is starting to be limited because excessive use can cause negative side effects, such as the accumulation of toxins in the body. This study aims to evaluate the antioxidant activity of tetanus (Leea aequata L.) leaf extract using DPPH method. Free radicals generated during metabolism can cause cell damage and contribute to various degenerative diseases. Therefore, it is important to find effective sources of antioxidants. In this study, Tetanus leaves were extracted using 96% ethanol solvent through maceration method. Antioxidant activity was evaluated by measuring the IC50 value against DPPH radical. The results showed that tetanus leaf extract had an IC50 value of 39.484 ppm, which indicated significant antioxidant activity. These results indicate that tetanus leaf extract can function as a free radical scavenging agent, which could potentially serve as a raw material in the development of herbal medicine to prevent oxidative stress-related diseases.
Identifikasi Glibenklamid Pada Jamu Kencing Manis Yang Beredar di Medan Johor Andriani, Vina; Sembiring , Novitaria Br; Bangar, Roy Indrianto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.889

Abstract

Background: The increasing use of traditional herbal medicine (jamu) for diabetes treatment in the community has been accompanied by a rise in counterfeiting practices, particularly through the addition of synthetic drugs such as glibenclamide (C₂₃H₂₈ClN₃O₅S) to enhance efficacy and sales. This poses potential health risks, thereby necessitating strict monitoring of circulating herbal products. Objective: This study aims to identify the presence of glibenclamide in three samples of antidiabetic jamu available in Medan Johor using Fourier-Transform Infrared Spectroscopy (FTIR). Method: Identification was carried out by comparing the FTIR spectra of the samples (wavenumber range 650–4000 cm⁻¹) with that of the BPFI glibenclamide standard. The characteristic functional groups of glibenclamide used as reference were 3369.5 cm⁻¹ (Amide N–H Stretching), 1714.6 cm⁻¹ (C=O Stretching), and 1155.5 cm⁻¹ (S=O Stretching). Results: The analysis showed that none of the three samples (A2, A3, A4) exhibited absorption peaks corresponding to the critical wavenumbers of glibenclamide. Therefore, the tested samples were declared free from the pharmaceutical chemical substance (PCS) glibenclamide. Conclusion: These findings indicate that the three jamu products are safe for consumption when used as directed. However, routine surveillance by the National Agency of Drug and Food Control (BPOM) remains essential to ensure the safety of herbal products on the market. Further studies using more sensitive methods such as UV-Vis spectrophotometry are recommended to verify these results.
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight) Walp.) Dengan Metode DPPH Wilson Kanggaran; Razoki, Razoki; Roy Indrianto Bangar Siagian; Hariyadi Dharmawan Syahputra
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2927

Abstract

Bay leaf (Syzygium polyanthum (Wight) Walp.) is known to contain phenolic and flavonoid compounds with potential as natural antioxidants. This study aims to evaluate the antioxidant activity of ethanol extract of bay leaves using the DPPH method and to identify the bioactive compounds through phytochemical screening and simplicia characterization. Extraction was conducted using maceration with 80% ethanol as the solvent. Characterization result showed that the bay leaf simplicial met the standards of the Farmakope Herbal Indonesia. Phytochemical screening revealed positive results for alkaloids, flavonoids, saponins, tannins, and phenols. The antioxidant activity test showed that the ethanol extract of bay leaves had an IC50 value of 15,45 ppm, which falls into the very strong antioxidant category. These findings reinforce the potential of bay leaf as a natural antioxidant source that can be further developed in pharmaceutical and health applications.
Screening of Drug Interaction Prescreption for Outpatients with Diabetes Mellitus and Hypertension from October to December 2023 at Advent Hospital Medan Khairatunawa, Tisa; Bangar, Roy Indrianto
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.101

Abstract

Diabetes mellitus and hypertension are two chronic conditions that frequently occur simultaneously and require long-term pharmacological therapy. The combination of treatments in patients with both diseases increases the potential for drug interactions, which can compromise therapeutic effectiveness and elevate the risk of adverse effects. This study aimed to evaluate the severity of drug interactions in outpatients with diabetes mellitus and hypertension at Advent Hospital Medan during the period from October to December 2023. A non-experimental descriptive study with a cross-sectional design was employed, using retrospective data from 191 outpatient prescriptions that met the inclusion criteria. Evaluation was conducted on administrative, pharmaceutical, and clinical aspects of the prescriptions, with a primary focus on identifying drug interactions using the reference database Drugs.com. The results showed that drug interactions were present in 52.4% of the analyzed prescriptions. Most interactions were classified as moderate in severity, predominantly involving pharmacodynamic mechanisms. The most frequent interacting drug combinations included metformin, glimepiride, amlodipine, bisoprolol, and candesartan. The high prevalence of drug interactions among patients with diabetes mellitus and hypertension highlights the importance of systematic prescription screening as a preventive measure. These findings can serve as a basis for developing rational drug use policies and enhancing patient safety in clinical practice.
Co-Authors Adelia Pratiwi Ain Naia Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br Ginting Astriani Natalia Br. Ginting Astriani Natalia Br. Ginting Astyka, Ririn Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Br Ginting, Astriani Natalia Br Pinem, Elys Dayanty Br Sembiring, Novitaria Br Tarigan, Jenny Alfa Dilla Cut Rahil Sofia Daimah W. S. Harahap Daulay, Wardiyah Desita, Maya Desmina Nur Cahaya Simanjuntak Edy Fachrial Erida Novriani Erida Novriani Ginting, Astriani Natalia Br Harahap, Daimah Wirdatus Sanaun Hardivia Kaur Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hotma sarito Panjaitan IKHTIARI, REFI Inesha Viata Melika Purba Josita Jenny Haryanti Hutagulung Kaban, Vera E. Kevin Wijaya Khairatunawa, Tisa Kinanti Maharani Lampita Bellina Manullang Lubis, Muhammad F. Lumban Gaol, Irma Yohana Michelle Veronica Gulo gulo Muhamad Insanu Muhammad Yunus Muhammad Yunus Muhammad Yunus Muhtamilatur Rahma Nailan Azizah Nasution, Haris M. Nasution, Irma Suryani Nerly Juli Pranita Simanjuntak Nerly Juli Pranita Simanjuntak Ningsih, Kurnia Nastira Ningsih, Wulan Seppia Nova Ria Ovelti Sihotang Novelia Zwi Dwinayanti Silaban Novia Agustini Irmasyari Siregar Novrika Desclarita Naibaho Nurhadijah Sibagariang Pasti Marito Samosir Permata Gulo, Elastis Rachel Adriany Br Sinaga Rahmana Emran Kartasasmita Razoki Razoki Razoki Razoki Razoki Razoki Razoki, Razoki Refi Ikhtiari Rio Sinar Parsaoran Simanullang Sembiring , Novitaria Br Sembiring, Novitaria Br Shintjia Dewi Agustan Sihotang, Nurhanifah Simanjuntak, Nerly Juli Pranita Siregar, Anggie Patrisia Siregar, Nurhakiki Tasyah Helgiera Tiani Nduru Tya Bella Arthamarisi Simbolon Utama, Rezza F. Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban Vera Estefania Kaban vina andriani Vinando Vinando Waruwu, Loice Desy Krisna Yanti Wilson Kanggaran Yerly Ramadani Lubis Yulyana, Ana