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All Journal Jurnal Kedokteran Brawijaya Brawijaya Journal of Urology
Wijaya, Mangkubumi Putra
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Health Professions Medicine & Pharmacology

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Advances in Urology: A Comprehensive Literature Review on Urolithiasis Management and Innovations Ramadhan, Reza Dwi; Wijaya, Mangkubumi Putra; Hidayat, Dzaky Ramadhan
Brawijaya Journal of Urology Vol. 6 No. 01 (2025): Brawijaya Journal of Urology
Publisher : Department of Urology, Faculty of Medicine, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/bjurology.2025.006.01.3

Abstract

Introduction. Urolithiasis is a prevalent condition, affecting approximately 12% of the global population at some point in their lives, with higher incidence rates reported in industrialized nations. This condition poses significant health challenges worldwide due to its recurrence and the associated healthcare burden. Recent innovations in imaging, minimally invasive techniques, and pharmacotherapy have revolutionized the field. This review aims to explore recent updates and innovations in the management of urolithiasis, from diagnosis to therapy. Methods. A systematic search using predefined keywords in multiple databases was done. Peer-reviewed articles, clinical trials, meta-analyses, and systematic reviews focused on urolithiasis management, diagnostic techniques, therapeutic innovations, and preventive strategies were analyzed. Articles from January 2015—December 2023 were included, reviewed for its eligibility, and extracted. Results. Emerging pharmacological agents (eg. empagliflozin, thiosulfate) offer new avenues for prevention and recurrence reduction, particularly for patients with recurrent urolithiasis, although not as primary therapy. Additionally, the integration of artificial intelligence and machine learning is beginning to play a role in predicting stone recurrence and optimizing treatment plans. Conclusion. This review highlights the importance of a personalized, patient-centered approach in managing urolithiasis, emphasizing the need for ongoing research and clinical trials to further refine these innovations. Keywords: artificial intelligence, disease management, urinary stone disease, urolithiasis
Comparisons of Karnofsky Score, Quality of Life, and Glomerular Filtration Rate in Cervical Cancer Patients with Bilateral Obstructive Uropathy before and after DJ Stent Insertion Daryanto, Besut; Wijaya, Mangkubumi Putra; Seputra, Kurnia Penta
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Cervical cancer is the second most common cancer in Indonesia, and it can lead to urinary tract obstruction. Obstructive uropathy can progress to hydronephrosis and kidney failure with a poor prognosis and can lead to several complications such as sepsis and uremia.  This study aims to compare outcomes of advanced-stage cervical cancer patients with obstructive uropathy who underwent DJ stent insertion versus those who did not at Saiful Anwar Malang General Hospital in Indonesia. An observational study conducted with a prospective cohort approach. Data collection was done through purposive sampling. Inclusion criteria include cervical cancer patients with bilateral obstructive uropathy who undergo DJ stent insertion and who failed or refused DJ stent insertion at the Saiful Anwar General Hospital. Paired T-tests were conducted to compare patients before and after DJ stent insertion, and unpaired T-tests were performed to compare patients who underwent DJ stent insertion and who did not. Glomerular Filtration Rate (GFR), Karnofsky Score (KS), and Quality of Life (QoL) Values before DJ stent insertion were 0.382, 0.454, and 0.246, respectively. After 3 months, these values were found to be 0.002, 0.000, and 0.002, respectively. DJ stent insertion has been proven to improve the quality of life, performance status, and kidney function in patients with cervical cancer and obstructive uropathy.
Co-Authors Hidayat, Dzaky Ramadhan Kurnia Penta Seputra Ramadhan, Reza Dwi