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Advances in Urology: A Comprehensive Literature Review on Urolithiasis Management and Innovations Ramadhan, Reza Dwi; Wijaya, Mangkubumi Putra; Hidayat, Dzaky Ramadhan
Brawijaya Journal of Urology Vol. 6 No. 01 (2025): Brawijaya Journal of Urology
Publisher : Department of Urology, Faculty of Medicine, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/bjurology.2025.006.01.3

Introduction. Urolithiasis is a prevalent condition, affecting approximately 12% of the global population at some point in their lives, with higher incidence rates reported in industrialized nations. This condition poses significant health challenges worldwide due to its recurrence and the associated healthcare burden. Recent innovations in imaging, minimally invasive techniques, and pharmacotherapy have revolutionized the field. This review aims to explore recent updates and innovations in the management of urolithiasis, from diagnosis to therapy. Methods. A systematic search using predefined keywords in multiple databases was done. Peer-reviewed articles, clinical trials, meta-analyses, and systematic reviews focused on urolithiasis management, diagnostic techniques, therapeutic innovations, and preventive strategies were analyzed. Articles from January 2015—December 2023 were included, reviewed for its eligibility, and extracted. Results. Emerging pharmacological agents (eg. empagliflozin, thiosulfate) offer new avenues for prevention and recurrence reduction, particularly for patients with recurrent urolithiasis, although not as primary therapy. Additionally, the integration of artificial intelligence and machine learning is beginning to play a role in predicting stone recurrence and optimizing treatment plans. Conclusion. This review highlights the importance of a personalized, patient-centered approach in managing urolithiasis, emphasizing the need for ongoing research and clinical trials to further refine these innovations. Keywords: artificial intelligence, disease management, urinary stone disease, urolithiasis

Comparisons of Karnofsky Score, Quality of Life, and Glomerular Filtration Rate in Cervical Cancer Patients with Bilateral Obstructive Uropathy before and after DJ Stent Insertion Daryanto, Besut; Wijaya, Mangkubumi Putra; Seputra, Kurnia Penta
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.2

Cervical cancer is the second most common cancer in Indonesia, and it can lead to urinary tract obstruction. Obstructive uropathy can progress to hydronephrosis and kidney failure with a poor prognosis and can lead to several complications such as sepsis and uremia. This study aims to compare outcomes of advanced-stage cervical cancer patients with obstructive uropathy who underwent DJ stent insertion versus those who did not at Saiful Anwar Malang General Hospital in Indonesia. An observational study conducted with a prospective cohort approach. Data collection was done through purposive sampling. Inclusion criteria include cervical cancer patients with bilateral obstructive uropathy who undergo DJ stent insertion and who failed or refused DJ stent insertion at the Saiful Anwar General Hospital. Paired T-tests were conducted to compare patients before and after DJ stent insertion, and unpaired T-tests were performed to compare patients who underwent DJ stent insertion and who did not. Glomerular Filtration Rate (GFR), Karnofsky Score (KS), and Quality of Life (QoL) Values before DJ stent insertion were 0.382, 0.454, and 0.246, respectively. After 3 months, these values were found to be 0.002, 0.000, and 0.002, respectively. DJ stent insertion has been proven to improve the quality of life, performance status, and kidney function in patients with cervical cancer and obstructive uropathy.

Calculus Formation in Bladder from Migrated Intrauterine Devices Wijaya, Mangkubumi Putra; Seputra, Kurnia Penta; Daryanto, Besut; Budaya, Taufiq Nur
Jurnal Kedokteran Brawijaya Vol. 32 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.02.11

Migration of the intrauterine device (IUD) into the bladder has been a rare case. There were reported 31 cases of IUD migration into the bladder until 2006. Although IUD migration is asymptomatic, it should be removed to prevent complications such as pelvic abscess, bladder or intestinal rupture, and adhesion. A 52-year-old woman came to the urology clinic with pyuria since the previous 3 months. She had a history of IUD insertion in 1982; and two months later, she got pregnant. Since 2015, she has suffered from dysuria but has never been treated and has worsened in the past 3 months. On physical examination, tenderness was found in the suprapubic region. The results of urinalysis showed pyuria and hematuria. The ultrasonography findings, there were large bladder stones. An abdominal x-ray revealed the presence of a bladder stone with the IUD tail. Vesicolithotomy was performed and the IUD was found attached to an 11x7 cm bladder stone. The patient had a good postoperative condition without any special complications. The IUD in the bladder is a medium for forming secondary bladder stones. Most cases of IUD migration are caused by a lack of evaluation after the installation procedure. This case suggested that the physician should be more careful in carrying out the installation procedure. It is necessary to evaluate the location of the IUD after installation to prevent further patient complications.

Comparisons of Karnofsky Score, Quality of Life, and Glomerular Filtration Rate in Cervical Cancer Patients with Bilateral Obstructive Uropathy before and after DJ Stent Insertion Daryanto, Besut; Wijaya, Mangkubumi Putra; Seputra, Kurnia Penta
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.2

Cervical cancer is the second most common cancer in Indonesia, and it can lead to urinary tract obstruction. Obstructive uropathy can progress to hydronephrosis and kidney failure with a poor prognosis and can lead to several complications such as sepsis and uremia. This study aims to compare outcomes of advanced-stage cervical cancer patients with obstructive uropathy who underwent DJ stent insertion versus those who did not at Saiful Anwar Malang General Hospital in Indonesia. An observational study conducted with a prospective cohort approach. Data collection was done through purposive sampling. Inclusion criteria include cervical cancer patients with bilateral obstructive uropathy who undergo DJ stent insertion and who failed or refused DJ stent insertion at the Saiful Anwar General Hospital. Paired T-tests were conducted to compare patients before and after DJ stent insertion, and unpaired T-tests were performed to compare patients who underwent DJ stent insertion and who did not. Glomerular Filtration Rate (GFR), Karnofsky Score (KS), and Quality of Life (QoL) Values before DJ stent insertion were 0.382, 0.454, and 0.246, respectively. After 3 months, these values were found to be 0.002, 0.000, and 0.002, respectively. DJ stent insertion has been proven to improve the quality of life, performance status, and kidney function in patients with cervical cancer and obstructive uropathy.

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