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All Journal Biology, Medicine, & Natural Product Chemistry Borneo Journal of Pharmacy
Hamid, Abdulmumeen Amao
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Isolation and Characterization of Constituents from The Extracts of Momordica angustisepala Aerial Parts Hamid, Abdulmumeen Amao; Egharevba, Godshelp Osas; Issa, Shuab Bolaji; Olalere, Oluwafeyikemi Mercy; Akinloye, Bukunmi Temitope; Yakub, Yakub Tunde
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.323-326

Abstract

N-hexane, ethyl acetate and methanol extracts of Momordica angustisepala were screened for the presence of metabolites, using column and thin-layer chromatographic techniques. Octadecane (1), tetradec-5-enoic acid (2), 1,2,3-propanetriyl (8Z,11’Z,14”Z)tris(-8,11,14-eicostrienoate) (3), methyl oleana-5,12,15-trienoate-3β-acetate (4) and 1,2,3-propanetriyl (9Z,12’Z,15”Z)tris(-9,12,15-uneicostrienooate) (5) are the compounds obtained from the extracts of M. angustisepala aerial parts using proton and 13C Nuclear Magnetic Resonance Spectroscopy (NMR).
Chemoinformatic-aided Antidiabetic Analysis of the Therapeutic Potential of Phytoconstituents in Eremomastax speciosa Extracts Ibrahim, Sulyman Olalekan; Lukman, Halimat Yusuf; Ebhohimen, Israel Ehizuelen; Babamale, Halimah Funmilayo; Abdulkadir, Fatimah Ronke; Hamid, Abdulmumeen Amao; Zubair, Marili Funmilayo; Atolani, Olubunmi
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6820

Abstract

This research attempts to establish the antihyperglycemic potential of Eremomastax speciosa, a medicinal plant utilized in traditional West African diabetes therapy, through virtual simulation. While numerous reports have validated its biological potency, studies on the drug-likeness and antidiabetic properties of its compounds are limited.  The in silico pharmacological, and toxicological profile of aqueous, methanolic/methylene phytochemicals from previously reported work was analyzed using Swiss ADME and Protox II online server. The docking process was performed using PyRx-0.8, coupled with AutoDock Vina. Phytochemicals that aligned with Lipinski’s rules for drugs were then subjected to a virtual docking simulation. This simulation replicated the inhibitory effects of E. speciosa phytochemicals on sodium-glucose co-transporters (SGLT2) and α-amylase, similar to metformin, an FDA-approved antidiabetic medicine utilized as a control. Phytochemicals such as 8, 9,10-dimethyltricyclo[4.2.1.1(2,5)]decane-9,10-diol (-6.6 kcal/mol), 11-isopropylidenetricyclo[4.3.1.1(2,5)]undec-3-en-10-one (-7.9 kcal/mol), 4-(1,5-dihydroxy-2,6,6-trimethylcyclohex-2-enyl)but-3-en-2-one (-7.3 kcal/mol), and N-methyl-N-4-[2-acetoxymethyl-1-pyrrolidyl]-2-butynyl]-acetamide (-7.5 kcal/mol) exhibits superior binding affinities to the specific proteins targeted, compared to metformin, implying that E. speciosa is a source of druggable antidiabetic molecules that can be enhanced to achieve better efficacy.
GC-MS Determination of Bioactive Components with Their Biological Activities of Olax subscorpioidea (Olacaceae) Odoma, Saidi; Adekilekun, Ajibola Habeebulahi; Onohuean, Hope; Funso, Funso-Babarimisa; Oyewusi, Adekilekun Habeebat; Hamid, Abdulmumeen Amao
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1437-1449

Abstract

Medicinal plants have been an integral part of healthcare, particularly in Africa, where over 80% of the population relies on traditional herbal medicine. This research focuses on Olax subscorpioidea, a plant recognized for its extensive pharmacological activities, including anti-inflammatory, antioxidant, antidiabetic, and analgesic properties. The study aimed to identify the bioactive compounds present in the leaf extract of O. subscorpioidea using Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The plant was collected, dried, and extracted with methanol, leading to the identification of 199 compounds, including phenols, terpenoids, flavonoids, and fatty acids, some of which possess significant biological activities. Toxicological studies indicated a safe dosage with no adverse effects observed in mice. This research underscores the potential of O. subscorpioidea as a source of novel therapeutic agents, necessitating further isolation and characterization of its bioactive constituents to explore their pharmacological potentials comprehensively.
Co-Authors Abdulkadir, Fatimah Ronke Adekilekun, Ajibola Habeebulahi Akinloye, Bukunmi Temitope Atolani, Olubunmi Babamale, Halimah Funmilayo Ebhohimen, Israel Ehizuelen Egharevba, Godshelp Osas Funso, Funso-Babarimisa Ibrahim, Sulyman Olalekan Issa, Shuab Bolaji Lukman, Halimat Yusuf Odoma, Saidi Olalere, Oluwafeyikemi Mercy Onohuean, Hope Oyewusi, Adekilekun Habeebat Yakub, Yakub Tunde Zubair, Marili Funmilayo