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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Menara Perkebunan Bioma : Jurnal Biologi dan Pembelajaran Biologi
Isnaini, Hanik
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education

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Pharmacological Benefits of Porang (Amorphophallus muelleri Blume): A Review Isnaini, Hanik; Yuhana, Titan Memory; Sholehah, Washeilatus; Jannah, Akyunul
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 2 (2025): June 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i2.10308

Abstract

Porang (Amorphophallus muelleri Blume) is a tuber plant from the Araceae family that grows wild in Indonesian forests. Porang tubers have a high content of the active compound glucomannan, a low-calorie hydrocolloid dietary fiber with various health benefits. However, its potential in the pharmaceutical field has not been fully explored scientifically, so this scientific review aims to explore the potential of glucomannan and other bioactive compounds in porang in the pharmaceutical field based on literature studies, as well as the challenges of developing it as a leading commodity in Indonesia. In addition to glucomannan, porang also contains secondary metabolites such as alkaloid, flavonoids, saponins, tannins, and steroids. Research studies show that porang can be used in the treatment of various diseases, such as diabetes (especially type-2 diabetes mellitus), obesity, hypertension, and has the potential as anti-cholesterol, anti-tumor, anti-inflammatory, prebiotic agent, anti-bacterial, and wound healing. The majority of applications that are still in preclinical in vivo trials on experimental animals and the presence of calcium oxalate as an irritant compound are the challenges of developing Porang as herbal medicine. Therefore, the use of porang as herbal medicine still requires further research regarding safe processing and clinically appropriate dosage. Keywords: cacao fruit-rot, Phytophthora palmivora, biological control, decomposer.
In silico test of brotowali (Tinospora crispa) as potential anticancer agent targeting mTOR on colorectal cancer Isnaini, Hanik; Agustin RJ, Adinda Amalia; Sholehah, Washeilatus; Sudarlina, Nida; Oktafia, Safina; Khodariyah, Luluk Ayu; Mumpuni, Siwi Putri
Menara Perkebunan Vol. 93 No. 1 (2025): 93(1), 2025
Publisher : INDONESIAN OIL PALM RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iribb.jur.mp.v93i1.595

Abstract

Colorectal cancer is one of the deadliest diseases in the world. Treatment to overcome colorectal cancer has been pursued in such a way. Still, theresults are unsatisfactory, so treatment turns to herbal plants such as brotowali (Tinospora crispa) as an alternative colorectal anticancer. T.crispa  is one of the herbal plants that contains a typical compound in the form of N-acetylnornuciferine and alkaloid-derived active compounds in the form ofN-formylanonaine, N- trans-coumaroyltyramine, and Tyramine which are potential as colorectal anticancer agents. The study used the mTOR(Mammalian Target of Rapamycin) receptor with PDB code (4DRJ) with its native ligand, RAP (receptor-associated protein). This study aims to analyze the potential of colorectal anticancer targeted by active compounds of alkaloid derivatives in T.crispa against mTOR. The method used is to explore active compounds through the KnapSack web and 3D protein structures on NCBI, docking validation using PyMol, tethering compounds N-acetylnornuciferine, N-formylanonaine, N-trans-coumaroyltyramine, and Tyramine to the target ligand using Pyrx and then visualized using BIOVIA Discovery Studio Visualizer. Analysis of the in silico test results showed that the compounds of N-acetylnornuciferine, N-trans-coumaroyltyramine, and Tyramine in T.crispa have good potential as colorectal anticancer agents in low doses but are not recommended for people with heart disease.
Optimasi Pertumbuhan Dendrobium sp. pada Tahap Aklimatisasi Menggunakan Esktrak Tauge Isnaini, Hanik; Suyono, Suyono
Bioma : Jurnal Biologi dan Pembelajaran Biologi Vol. 9 No. 2 (2024): BIOMA: JURNAL BIOLOGI DAN PEMBELAJARAN BIOLOGI
Publisher : Universitas Muhammadiyah Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32528/bioma.v9i2.1361

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh aplikasi ekstrak tauge pada berbagai konsentrasi terhadap optimasi pertumbuhan planlet Dendrobium sp. pada tahap aklimatisasi. Penelitian ini menggunakan Rancangan Acak lengkap (RAL) dengan konsentrasi ekstrak tauge 0% (kontrol), 30%, 60%, dan 90%. Parameter yang diamati ialah tinggi tunas, jumlah akar, panjang akar, dan luas daun. Data yang diperoleh dianalisis menggunakan analisis variansi (ANOVA) dan dilakukan uji lanjut (DMRT) serta analisis regresi. Hasil penelitian menunjukkan aplikasi ekstrak tauge berpengaruh nyata terhadap tinggi tunas. Konsentrasi ekstrak tauge paling optimum terletak pada taraf 42,25% dengan rerata tinggi tunas mencapai 6,28cm setelah itu mengalami penurunan karena sifat inhibitor dari dosis ekstrak tauge yang terlalu tinggi dan kapasitas tanaman dalam absorpsi pasokan hara. Sedangkan pertumbuhan pada parameter jumlah akar, panjang akar, dan luas daun menunjukkan perbedaan yang tidak signifikan dengan kelompok kontrol.
Pharmacological Benefits of Porang (Amorphophallus muelleri Blume): A Review Isnaini, Hanik; Yuhana, Titan Memory; Sholehah, Washeilatus; Jannah, Akyunul
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 2 (2025): June 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i2.10308

Abstract

Porang (Amorphophallus muelleri Blume) is a tuber plant from the Araceae family that grows wild in Indonesian forests. Porang tubers have a high content of the active compound glucomannan, a low-calorie hydrocolloid dietary fiber with various health benefits. However, its potential in the pharmaceutical field has not been fully explored scientifically, so this scientific review aims to explore the potential of glucomannan and other bioactive compounds in porang in the pharmaceutical field based on literature studies, as well as the challenges of developing it as a leading commodity in Indonesia. In addition to glucomannan, porang also contains secondary metabolites such as alkaloid, flavonoids, saponins, tannins, and steroids. Research studies show that porang can be used in the treatment of various diseases, such as diabetes (especially type-2 diabetes mellitus), obesity, hypertension, and has the potential as anti-cholesterol, anti-tumor, anti-inflammatory, prebiotic agent, anti-bacterial, and wound healing. The majority of applications that are still in preclinical in vivo trials on experimental animals and the presence of calcium oxalate as an irritant compound are the challenges of developing Porang as herbal medicine. Therefore, the use of porang as herbal medicine still requires further research regarding safe processing and clinically appropriate dosage. Keywords: cacao fruit-rot, Phytophthora palmivora, biological control, decomposer.
Co-Authors Agustin RJ, Adinda Amalia Akyunul Jannah Khodariyah, Luluk Ayu Mumpuni, Siwi Putri Oktafia, Safina Sholehah, Washeilatus Sudarlina, Nida Suyono Suyono Yuhana, Titan Memory