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All Journal Majalah Ilmiah METHODA
Siahaan, Dwi Lunarta Docterina Sutanti
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Agriculture, Biological Sciences & Forestry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health

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Regional Anestesia dengan Teknik Thoraco Spinal Anesthesia (TSA): Manfaat dan Tantangan dalam Praktik Anestesiologi Siahaan, Dwi Lunarta Docterina Sutanti
Majalah Ilmiah METHODA Vol. 15 No. 1 (2025): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol15No1.pp38-42

Abstract

Thoracic spinal anesthesia (TSA) is a regional anesthesia technique increasingly used in clinical practice as an alternative to general anesthesia, particularly in thoracoabdominal and upper extremity surgeries. This technique offers several benefits, including optimal pain control, hemodynamic stability, and faster recovery. However, the application of TSA also presents challenges, such as the need for specialized skills, the risk of hypotension, and proper patient selection. This article discusses the benefits and challenges of TSA in modern anesthesiology practice and its implications for improving patient clinical outcomes.
Epigenetik dan Penuaan (Aging): Peluang Intervensi Molekuler untuk Hidup Sehat Lebih Lama Siahaan, Dwi Lunarta Docterina Sutanti; Lim, Hadyanto
Majalah Ilmiah METHODA Vol. 15 No. 1 (2025): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol15No1.pp62-68

Abstract

Aging is a complex biological process characterized by a decline in cellular function and increased susceptibility to degenerative diseases. In recent decades, research has shown that epigenetic modifications—such as DNA methylation, histone modification, and regulation by non-coding RNAs—play a key role in the aging process. These changes influence gene expression without altering the DNA sequence and contribute to cellular damage, chronic inflammation, and tissue dysfunction. As scientific understanding advances, various epigenetic-based molecular interventions have emerged, including epigenetic reprogramming, senolytic therapies, and pharmacological and lifestyle approaches targeting epigenetic mechanisms. Although challenges remain in terms of safety, specificity, and clinical applicability, these approaches offer promising potential for extending healthspan and improving quality of life in later years.
Co-Authors Hadyanto Lim