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Chairina, Ade
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Effect of Jeruju Leaf Brew (Acanthus ilicifolius L) on HOMA-IR and TNF-α in White Rats Induce by STZ-NA Majdiyyah, Munifa; Chairina, Ade; Nur Afifah, Diana; Syauqy, Ahmad
Medical Laboratory Technology Journal Vol. 11 No. 1 (2025): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i1.648

Abstract

The International Diabetes Federation (IDF) has reported a consistent global rise in the prevalence of type 2 diabetes mellitus (T2DM). Conventional T2DM treatments such as metformin, sulfonylureas, and insulin therapy are effective. Still, they can lead to side effects, including gastrointestinal disturbances, hypoglycemia, renal impairment, weight gain, and complications associated with injection procedures. The herbal remedies are considered a natural alternative with fewer adverse effects. Acanthus ilicifolius (Jeruju) contains antioxidant compounds such as flavonoids, alkaloids, and saponins and may serve as a complementary therapy. This study investigated the effect of jeruju leaf brew at 6 ml/kg/day and 12 ml/kg/day on tumor necrosis factor alpha (TNF-α) and homeostatic model assessment of insulin resistance (HOMA-IR) levels. Using a true experiment with a randomized post-test only with a control group design, 30 rats were divided into five groups (K0, K−, K+, P1, and P2). After 28 days of intervention, groups P1 and P2 showed significant reductions in TNF-α (7.80 pg/ml and 6.94 pg/ml, respectively) and HOMA-IR (3.75 and 3.28, respectively). These findings indicate that a higher dose of jeruju leaf brew results in greater reductions in TNF-α and HOMA-IR levels in T2DM rats.
Jeruju (Acanthus ilicifolius) Leaf Infusion Modulates Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) Enzyme Activity in Streptozotocin-Nicotinamide (STZ-NA) Induced Diabetic Rats (Rattus norvegicus) Chairina, Ade; Majdiyyah, Munifa; Afifah, Diana Nur; Syauqy, Ahmad
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.482

Abstract

Type 2 diabetes mellitus is a metabolic disorder marked by chronic hyperglycemia and oxidative stress, which can reduce the activity of antioxidant enzymes like Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx). Acanthus ilicifolius (jeruju) contains antioxidant compounds such as flavonoids and phenolics that may enhance these enzyme activities. Evaluate the effect of Acanthus ilicifolius leaf infusion on SOD and GPx activity in Wistar rats induced with type 2 diabetes using Streptozotocin-Nicotinamide (STZ-NA). The experimental design used a post-test only with five groups: normal control (no diabetes, standard feed), positive control (diabetes + metformin 45 mg/kgBW), negative control (diabetes without treatment), treatment group 1 (diabetes + metformin 45 mg/kgBW + jeruju infusion 1.2 ml/200gBW), and treatment group 2 (diabetes + metformin 45 mg/kgBW + jeruju infusion 2.4 ml/200gBW). Treatments were given daily for 30 days, and all rats had free access to food and water. At the end of the study, blood samples were collected to measure SOD and GPx activity using spectrophotometry. The combination of Acanthus ilicifolius infusion and metformin particularly at the 2.4 ml/200gBW dose, was associated with elevated SOD P2 treatment group (76.23 ± 3.65 U/mL; p = 0.000 (<0.05)) and GPx activities P2 (52.11 ± 0.76 U/mL; p = 0.000 (<0.05))  compared to the untreated diabetic group K- (SOD) (28.43 ± 3.17 U/mL) and K- (GPx)(24.18 ± 1.08 U/mL). These findings proves Acanthus ilicifolius infusion holds potential as an adjuvant therapy to mitigate oxidative stress in type 2 diabetes by enhancing SOD and GPx enzyme activities.
Co-Authors Ahmad Syauqy Diana Nur Afifah, Diana Nur Majdiyyah, Munifa Nur Afifah, Diana