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All Journal International Journal of Applied and Scientific Research (IJASR)
Mathew, Uwuigbe
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Evaluation of the Histological Effects of Allium Cepa Administration on the Prostate Histology and Prostate Specific Antigen of Male Albino Rats Induced with Ciprofloxacin Mathew, Uwuigbe; Ohiwerei Wisdom Omogbai; Edebiri Ogbemudia E; Ajanwachukwu Ogbonna Wilson; Oriahoghen E E
International Journal of Applied and Scientific Research Vol. 2 No. 11 (2024): November 2024
Publisher : MultiTech Publisher

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The primary objective of this study is to assess the histological impact of Allium cepa administration on prostate histology and prostate-specific antigen (PSA) levels in male albino rats that were induced with ciprofloxacin. A total of 100 albino rats, each weighing between 150–250g, were used in the experiment. The experimental group was further divided into four subgroups, each containing 10 rats, labeled as Groups A, B, C, D, and E. Group A served as the control, while Group B received only ciprofloxacin. Group C was administered ciprofloxacin along with 100mg of Allium cepa extract, whereas Group D received ciprofloxacin and 200mg of Allium cepa extract. Group E was treated solely with Allium cepa extract. Groups B, C, and D were given 22.86 mg/kg of oral ciprofloxacin (500 mg/tablet), manufactured by Fidson Health Care Ltd. The ciprofloxacin was obtained from a reputable pharmaceutical store in Ekpoma, Edo State, and administered via gavage. The control group was provided with only water and food. The PSA levels in control and test subjects were recorded as Mean ± SEM. For the control group, the PSA level was 0.6250 ± 0.085 ng/ml. The PSA levels for test groups B, C, D, and E were 1.575 ± 0.417 ng/ml, 1.200 ± 0.123 ng/ml, 1.125 ± 0.048 ng/ml, and 3.300 ± 0.835 ng/ml, respectively. Notably, only Group E exhibited a significant increase (P<0.05) in PSA levels when compared to the control group.In conclusion, this study indicates that exposure to ciprofloxacin and Allium cepa at mild or moderate doses can lead to severe histopathological changes in the testis, prostate, and epididymis, with the exception of the brain
Assessment of the Effect of Graded Doses Alligator Pepper on Uterus of Female Albino Rats Mathew, Uwuigbe; Ohiwerei Wisdom Omogbai; Amina Momodu; Ogbe O Clementina
International Journal of Applied and Scientific Research Vol. 2 No. 12 (2024): December 2024
Publisher : MultiTech Publisher

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The aim of this study is to determine the histological effects of alligator on the uterus of wistar rats, as a result of different doses of alligator administered orally. Fifty (50) adult female wistar rats were use for this study for a period of 28 days (14 days for aclimitization and 14 days for administration). The rats were randomized and divided into five groups (A, B, C, D and E) of ten (10) animals each. the animals were sacrificed two times. All animals were sacrificed by cervical dislocation at least three hours after the last administration of alligator pepper. The results showed the weight before acclimatization, after acclimatization, before sacrifice of control and test subjects in which the Mean±SEM of weight before acclimatization, after acclimatization, before sacrifice were 247±3.00, 226±2.00 and 226±2.00 respectively for control subjects. None of the test groups were found statistically significant (p<0.05) when compared with their respective control. The micrograph result showed that ovary group A in the photomicrograph had a normal histological features. Uterus group B administered with 100mg/kg of aqueous extracts of alligator pepper showed clear carcinoma (neoplastic changes) of the endomentry uterus. Uterus group C (200mg of Alligator pepper) and group D (300mg of Alligator pepper) showed hyperplasic cells of the endomentry uterus. Uterus group E (400g of Alligator pepper) photomicrograph showed andenomyosis endoutrolysis internal. In conclusion, hyperplasic cells ( a condition suggestive of Hyperplasia) was found to be more common in groups with moderate doses. This study suggests that the oral administration of Alligator pepper at mild or moderate doses could cause severe histopathologic changes in the uterus without having any adverse effect on body weight
Co-Authors Ajanwachukwu Ogbonna Wilson Amina Momodu Edebiri Ogbemudia E Ogbe O Clementina Ohiwerei Wisdom Omogbai Oriahoghen E E