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All Journal International Journal of Applied and Scientific Research (IJASR)
Ogbe O Clementina
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Religion Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Social Sciences

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Assessment of the Effect of Graded Doses Alligator Pepper on Uterus of Female Albino Rats Mathew, Uwuigbe; Ohiwerei Wisdom Omogbai; Amina Momodu; Ogbe O Clementina
International Journal of Applied and Scientific Research Vol. 2 No. 12 (2024): December 2024
Publisher : MultiTech Publisher

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Abstract

The aim of this study is to determine the histological effects of alligator on the uterus of wistar rats, as a result of different doses of alligator administered orally. Fifty (50) adult female wistar rats were use for this study for a period of 28 days (14 days for aclimitization and 14 days for administration). The rats were randomized and divided into five groups (A, B, C, D and E) of ten (10) animals each. the animals were sacrificed two times. All animals were sacrificed by cervical dislocation at least three hours after the last administration of alligator pepper. The results showed the weight before acclimatization, after acclimatization, before sacrifice of control and test subjects in which the Mean±SEM of weight before acclimatization, after acclimatization, before sacrifice were 247±3.00, 226±2.00 and 226±2.00 respectively for control subjects. None of the test groups were found statistically significant (p<0.05) when compared with their respective control. The micrograph result showed that ovary group A in the photomicrograph had a normal histological features. Uterus group B administered with 100mg/kg of aqueous extracts of alligator pepper showed clear carcinoma (neoplastic changes) of the endomentry uterus. Uterus group C (200mg of Alligator pepper) and group D (300mg of Alligator pepper) showed hyperplasic cells of the endomentry uterus. Uterus group E (400g of Alligator pepper) photomicrograph showed andenomyosis endoutrolysis internal. In conclusion, hyperplasic cells ( a condition suggestive of Hyperplasia) was found to be more common in groups with moderate doses. This study suggests that the oral administration of Alligator pepper at mild or moderate doses could cause severe histopathologic changes in the uterus without having any adverse effect on body weight
Histological Effect of Ultra Violet (UV) Light on the Testis of Albino Wistar Rats Uwuigbe Mathew; Ohiwerei Wisdom Omogbai; Ogbe O Clementina; Ajanwachukwu Ogbonna Wilson; Obeagu E I
International Journal of Applied and Scientific Research Vol. 2 No. 12 (2024): December 2024
Publisher : MultiTech Publisher

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UV light, or ultraviolet light, is a type of radiation that falls between the visible light and X-ray regions of the electromagnetic spectrum. It is a form of electromagnetic radiation emitted by the sun and artificial sources, such as tanning beds and UV lamps. It has a shorter wavelength than visible light, ranging from 100 to 400 nanometers (nm). It is categorized into three types based on their wavelengths: UVA, UVB, and UVC. The aim of this study is to evaluate the histopathological effect of uv light on the testis of male Wistar albino rats. A total of fifty (50) adult Albino Wistar rats of comparable sizes were used for this study. They were divided into four equal groups (A – E) with ten (10) rats each. Group A served as the control and the rats were given distilled water and feed only. In addition to feed and water, Groups B rats were kept under Uv light for 30mins, Group C rats were kept under Uv light for 1hour twice daily, Group D rats were kept under Uv light for 2 hours thrice daily and Group E were kept under Uv light for 4 hours thrice daily. The administration was given daily for 14 days (2 weeks) and the weights of both the test and control animals was monitored before and after administration of Uv light. After the administration, the rats were put under light chloroform anaesthesia and the stomach was obtained. ANOVA was used to analyze the results of the weight and differences was considered significant at p<0.05 level of confidence. All data was expressed in table as mean ± standard deviation (SD). From the results, it was observed that Group B showed mild adenofibroma, Group C exhibited denatured testicular cells, indicating severe damage. Group D had adenocarcinoma and fatty tissue, suggesting potential malignancy and Group E presented fatty tissue. In conclusion, the exposure of testis to uv light cause significant alterations in testis histology
Co-Authors Ajanwachukwu Ogbonna Wilson Amina Momodu Mathew, Uwuigbe Obeagu E I Ohiwerei Wisdom Omogbai Uwuigbe Mathew