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All Journal Jurnal Ilmu Keluarga dan Konsumen Jurnal Biologi Tropis
Amalia, Atikah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Immunology & microbiology Nursing Public Health Social Sciences

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Potential of Bioactive Compounds of Allium sativum L. var. solo garlic Extract in Inhibiting InhA Protein in Mycobacterium tuberculosis Rohmawati, Uun; Amalia, Atikah
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9119

Abstract

Tuberculosis (TB) is caused by the bacteria Mycobacterium tuberculosis. In general, TB is treated with compounds that inhibit the work of one of the enzymes in the bacteria Mycobacterium tuberculosis, namely the InhA enzyme. One of the herbal plants that has the potential to inhibit the InhA protein in the bacteria Mycobacterium tuberculosis is. Allium sativum L. var. solo garlic. This research aims to determine the bioactive compounds in Allium sativum L. var. solo garlic in inhibiting the InhA protein in Mycobacterium tuberculosis which can be used as an alternative drug in the treatment of TB through an in silico approach. The method used in this study was qualitative phytochemical screening and GCMS test on Allium sativum L. var. solo garlic extract, the bioactive compounds found were tested in silico through a molecular docking approach. The research results obtained that Allium sativum L. var. solo garlic contains alkaloids, flavonoids, tannins and steroids. Based on the results of the GCMS test, the bioactive compounds that have an area of ​​more than 5% are Heptadecene-(8)-Carbonic Acid-(1), 3-Deoxy-D-Mannonic Acid, 5-Hydroxymethylfurfural, Melezitose and Oleic acid. The results of molecular docking showed that the compound 3-Deoxy-D-mannonic acid had a binding affinity of -4.9, 5-Hydroxymethylfurfural -4.8, Oleic Acid -6.4, Nicotinamide-Adenine-Dinucleotide (Control) had a binding affinity of -11.4. Low binding affinity indicates that the compound can bind to the protein with little energy. The Gyps energy theory states that the smaller the energy produced from a bond between the ligand and its receptor, the more stable the bond is. The lowest binding energy to the InhA protein is in the control compound Nicotinamide-Adenine-Dinucleotide, Oleic Acid, 3-Deoxy-D-mannonic acid, 5-Hydroxymethylfurfural.
PERAN DUKUNGAN SOSIAL BAGI KESEJAHTERAAN PSIKOLOGIS FAMILY CAREGIVER ORANG DENGAN SKIZOFRENIA (ODS) RAWAT JALAN Amalia, Atikah; Rahmatika, Rina; Atikah Amalia
Jurnal Ilmu Keluarga dan Konsumen Vol. 13 No. 3 (2020): JURNAL ILMU KELUARGA DAN KONSUMEN
Publisher : Department of Family and Consumer Sciences, Faculty of Human Ecology, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.197 KB) | DOI: 10.24156/jikk.2020.13.3.228

Abstract

Ketidakmampuan memenuhi fungsi secara optimal merupakan tantangan yang harus dihadapi oleh family caregiver dalam melakukan perawatan pada pasien orang dengan skizofrenia (ODS) sehingga dibutuhkan dukungan sosial yang dapat meningkatkan kesejahteraan psikologis dari family caregiver ODS. Tujuan dari penelitian ini adalah untuk menganalisis peranan dari dukungan sosial terhadap kesejahteraan psikologis family caregiver ODS rawat jalan. Penelitian ini menggunakan pendekatan kuantitatif dengan teknik pemilihan contoh menggunakan non-probability purposive sampling. Sampel dalam penelitian ini berjumlah 57 partisipan. Data penelitian dikumpulkan dengan kuesioner multidimensional perceived social support (ά=0,659-0,757) dan Ryff Psychological well-being (ά=0,855-0,914) yang telah disesuaikan dengan subjek penelitian. Dukungan sosial diukur dari persepsi partisipan tentang dukungan sosial yang diperoleh. Hasil penelitian menunjukkan bahwa dimensi friends berperan signifikan terhadap dimensi personal growth, positive relationship, dan purpose in life dari kesejahteraan psikologis family caregiver ODS; sementara dimensi family berperan terhadap dimensi environtmental mastery. Hasil penelitian juga menemukan bahwa dimensi significant others tidak berperan signifikan terhadap semua dimensi dari kesejahteraan psikologis family caregiver ODS. Berdasarkan hasil penelitian, dukungan sosial yang dipersepsikan oleh family caregiver ODS rawat jalan berperan penting karena dapat meningkatkan kesejahteraan psikologisnya. Hal ini akan dapat mengoptimalkan perawatan yang diberikan oleh family caregiver yang akan berdampak pada proses pemulihan dari anggota keluarga yang mengalami skizofrenia.
Co-Authors Atikah Amalia Rina Rahmatika, Rina Rohmawati, Uun