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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Matematika Ilmiah Universitas Muhammadiyah Kuningan
Amelia Nisa
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Other

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PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS DENGAN PROBLEM BASED LEARNING BERBANTUAN GEOGEBRA Amelia Nisa; Sumliyah; Zaenal Abidin
JUMLAHKU: Jurnal Matematika Ilmiah STKIP Muhammadiyah Kuningan Vol 11 No 1 (2025): JUMLAHKU VOL.11 NO.1 2025
Publisher : Program Studi Pendidikan Matematika Universitas Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33222/jumlahku.v11i1.4543

Abstract

Riset ini memiliki sasaran untuk mengoptimalkan kompetensi problem-solving pada peserta didik. Fase prasiklus mengungkapkan bahwa kriteria kemampuan tersebut masih berada pada level yang rendah, dan kondisi inilah yang melatarbelakangi partisipasi peserta didik dalam riset ini. Materi yang peneliti ambil untuk penelitian ini yaitu SPtLDV dimana nantinya peserta didik mencari daerah hasil penyelesaian (DHP) pada grafik. Riset ini dikategorikan sebagai penelitian tindakan kelas yang melibatkan dua siklus. Pada siklus pertama, implementasi pembelajaran menggunakan model Problem Based Learning (PBL) dilakukan tanpa adanya dukungan media atau aplikasi. Hasil yang diperoleh per indikator unrtuk siklus I masih tergolong rendah karena dari ke empat indikator pemecahan masalah. Rata-rata yang diperoleh maasih tergolong rendah yaitu hanya sebesar 22,16 dan melakukan tindakan pada siklus II. Temuan yang didapatkan pada siklus II memperlihatkan progres yang substansial dibandingkan siklus I, tercermin dari peningkatan mean pada setiap indikator. Nilai rerata yang dicapai oleh peserta didik tergolong baik, yakni sebesar 72,25. Pada siklus kedua ini, implementasi model pembelajaran Problem Based Learning dioptimalkan dengan pemanfaatan aplikasi Geogebra.
PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS DENGAN PROBLEM BASED LEARNING BERBANTUAN GEOGEBRA Amelia Nisa; Sumliyah; Zaenal Abidin
JUMLAHKU: Jurnal Matematika Ilmiah STKIP Muhammadiyah Kuningan Vol 11 No 1 (2025): JUMLAHKU VOL.11 NO.1 2025
Publisher : Program Studi Pendidikan Matematika Universitas Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33222/jumlahku.v11i1.4543

Abstract

Riset ini memiliki sasaran untuk mengoptimalkan kompetensi problem-solving pada peserta didik. Fase prasiklus mengungkapkan bahwa kriteria kemampuan tersebut masih berada pada level yang rendah, dan kondisi inilah yang melatarbelakangi partisipasi peserta didik dalam riset ini. Materi yang peneliti ambil untuk penelitian ini yaitu SPtLDV dimana nantinya peserta didik mencari daerah hasil penyelesaian (DHP) pada grafik. Riset ini dikategorikan sebagai penelitian tindakan kelas yang melibatkan dua siklus. Pada siklus pertama, implementasi pembelajaran menggunakan model Problem Based Learning (PBL) dilakukan tanpa adanya dukungan media atau aplikasi. Hasil yang diperoleh per indikator unrtuk siklus I masih tergolong rendah karena dari ke empat indikator pemecahan masalah. Rata-rata yang diperoleh maasih tergolong rendah yaitu hanya sebesar 22,16 dan melakukan tindakan pada siklus II. Temuan yang didapatkan pada siklus II memperlihatkan progres yang substansial dibandingkan siklus I, tercermin dari peningkatan mean pada setiap indikator. Nilai rerata yang dicapai oleh peserta didik tergolong baik, yakni sebesar 72,25. Pada siklus kedua ini, implementasi model pembelajaran Problem Based Learning dioptimalkan dengan pemanfaatan aplikasi Geogebra.
Synergistic Effects of Stem Cell Integration on Cochlear Implant Performance in Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis of Neural Preservation and Speech Perception Dinera Anjani; Theresa Puspanadi; Ajeng Shanaz Santya Putri; Amelia Nisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1573

Abstract

Background: Cochlear implantation represents the paramount intervention for severe-to-profound sensorineural hearing loss. However, device efficacy is fundamentally constrained by retrograde degeneration of spiral ganglion neurons and post-insertional intracochlear fibrosis. This study aimed to quantitatively evaluate the synergistic efficacy of integrating stem cell therapies with cochlear implants to preserve neural architecture and enhance auditory functional outcomes. Methods: A systematic review and meta-analysis were executed following PRISMA guidelines. Comprehensive searches of electronic databases utilized specific Medical Subject Headings targeting biohybrid electrodes, mesenchymal stem cells, and spiral ganglion survival. Inclusion criteria strictly selected controlled in vivo preclinical models and human clinical trials evaluating concurrent stem cell application with implantation. Risk of bias was assessed utilizing SYRCLE and ROBINS-I tools. Random-effects models synthesized Standardized Mean Differences for neural preservation, with subgroup analyses evaluating delivery modalities. Results: Eight pivotal studies met stringent inclusion criteria. Meta-analysis demonstrated a highly significant preservation of spiral ganglion density in stem cell-integrated cohorts compared to implant-alone controls (Pooled Standardized Mean Difference = 2.45; 95% Confidence Interval: 1.54–3.36; p < 0.001). Subgroup analysis revealed that electrode coating yielded superior neuroprotection compared to bolus injections. Electrophysiological data demonstrated significantly lowered Electrically Evoked Auditory Brainstem Response thresholds. Clinical cohorts exhibited stable impedances and rapid improvements in speech perception. Conclusion: Stem cell-integrated cochlear implants orchestrate a potent bio-electronic synergy, modulating neuroinflammation and mitigating neural degeneration primarily through paracrine neurotrophic signaling. This bio-electronic integration represents a transformative paradigm in auditory rehabilitation, maximizing the fidelity of neural stimulation and optimizing clinical outcomes.
Synergistic Effects of Stem Cell Integration on Cochlear Implant Performance in Sensorineural Hearing Loss: A Systematic Review and Meta-Analysis of Neural Preservation and Speech Perception Dinera Anjani; Theresa Puspanadi; Ajeng Shanaz Santya Putri; Amelia Nisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1573

Abstract

Background: Cochlear implantation represents the paramount intervention for severe-to-profound sensorineural hearing loss. However, device efficacy is fundamentally constrained by retrograde degeneration of spiral ganglion neurons and post-insertional intracochlear fibrosis. This study aimed to quantitatively evaluate the synergistic efficacy of integrating stem cell therapies with cochlear implants to preserve neural architecture and enhance auditory functional outcomes. Methods: A systematic review and meta-analysis were executed following PRISMA guidelines. Comprehensive searches of electronic databases utilized specific Medical Subject Headings targeting biohybrid electrodes, mesenchymal stem cells, and spiral ganglion survival. Inclusion criteria strictly selected controlled in vivo preclinical models and human clinical trials evaluating concurrent stem cell application with implantation. Risk of bias was assessed utilizing SYRCLE and ROBINS-I tools. Random-effects models synthesized Standardized Mean Differences for neural preservation, with subgroup analyses evaluating delivery modalities. Results: Eight pivotal studies met stringent inclusion criteria. Meta-analysis demonstrated a highly significant preservation of spiral ganglion density in stem cell-integrated cohorts compared to implant-alone controls (Pooled Standardized Mean Difference = 2.45; 95% Confidence Interval: 1.54–3.36; p < 0.001). Subgroup analysis revealed that electrode coating yielded superior neuroprotection compared to bolus injections. Electrophysiological data demonstrated significantly lowered Electrically Evoked Auditory Brainstem Response thresholds. Clinical cohorts exhibited stable impedances and rapid improvements in speech perception. Conclusion: Stem cell-integrated cochlear implants orchestrate a potent bio-electronic synergy, modulating neuroinflammation and mitigating neural degeneration primarily through paracrine neurotrophic signaling. This bio-electronic integration represents a transformative paradigm in auditory rehabilitation, maximizing the fidelity of neural stimulation and optimizing clinical outcomes.
Co-Authors Ajeng Shanaz Santya Putri Dinera Anjani Sumliyah, Sumliyah Theresa Puspanadi Zaenal Abidin