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All Journal PROSIDING SEMINAR KIMIA JURNAL ATOMIK
Aditya, Adrian Maulana
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science

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SKRINING FITOKIMIA, UJI ANTIOKSIDAN DAN UJI TOKSISITAS EKSTRAK ETANOL DAUN BINTARO (Cerbera manghas) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Ramadani, Andi Deffi; Aditya, Adrian Maulana; T, Nurnaningsi; Erwin, Erwin
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

The purpose of this study was to determine the results of phytochemical tests of bintaro leaf ethanol extract and to determine the results of antioxidant tests using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a concentration variation of 100; 80; 60; 40; and 20 ppm obtained from bintaro leaf ethanol extract by testing its toxicity using the Brine Shrimp Lethality Test (BSLT) method. The results showed that the ethanol extract of bintaro leaves (Cerbera manghas) contains steroid compounds, saponins, and quinones. Furthermore, the IC50 value of the ethanol extract of bintaro leaves (C. manghas) was 41.68 ppm with a very strong category and the results of the toxicity test obtained the LC50 value of the ethanol extract of bintaro leaves (C. manghas) of 30.44 ppm with a very toxic category. An extract with an LC50 value ≤ 30 ppm has the potential as an anticancer drug candidate because of the correlation between the level of toxicity and anticancer activity so that these results can be concluded that the ethanol extract of bintaro leaves (C. manghas) has the potential to have bioactivity because it is toxic to Artemia salina L. shrimp larvae. Keywords: Antioxidant, Brine Shrimp Lethality Test (BSLT), Bintaro Leaves, Phytochemical Test
SINTESIS DAN KARAKTERISASI NANOPARTIKEL PERAK TERMODIFIKASI GLUTATHIONE MENGGUNAKAN REDUKTOR NaBH4 Aditya, Adrian Maulana; -, Daniel; Hindryawati, Noor
JURNAL ATOMIK Vol 10 No 2 (2025)
Publisher : Jurusan Kimia FMIPA UNMUL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/ja.v10i2.1549

Abstract

Silver nanoparticles (AgNPs) possess remarkable properties that make them suitable for various applications in biomedical, environmental, and catalytic fields. This study focuses on the synthesis and characterization of glutathione-modified silver nanoparticles (AgNPs-GSH) using sodium borohydride (NaBH₄) as a reducing agent. The reduction of AgNO₃ by NaBH₄ produces elemental silver nanoparticles, as indicated by a color change to bright yellow due to the localized surface plasmon resonance (LSPR) phenomenon. The synthesized nanoparticles were stabilized using glutathione (GSH), which binds through thiol (-SH), amine (-NH₂), and carboxyl (-COOH) functional groups, enhancing the stability and biocompatibility of the AgNPs. UV-Vis spectroscopic analysis revealed a maximum absorbance at 408 nm, consistent with the optical properties of silver nanoparticles. Furthermore, particle size analysis indicated an average nanoparticle size of 1.271 nm, with some degree of agglomeration. These findings suggest the successful synthesis and functionalization of AgNPs-GSH with potential applications in nanobiotechnology.
Co-Authors Daniel -, Daniel Erwin Erwin Noor Hindryawati, Noor Ramadani, Andi Deffi T, Nurnaningsi