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All Journal PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman
T, Nurnaningsi
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Chemistry

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SKRINING FITOKIMIA, UJI ANTIOKSIDAN DAN UJI TOKSISITAS EKSTRAK ETANOL DAUN BINTARO (Cerbera manghas) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Ramadani, Andi Deffi; Aditya, Adrian Maulana; T, Nurnaningsi; Erwin, Erwin
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

The purpose of this study was to determine the results of phytochemical tests of bintaro leaf ethanol extract and to determine the results of antioxidant tests using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a concentration variation of 100; 80; 60; 40; and 20 ppm obtained from bintaro leaf ethanol extract by testing its toxicity using the Brine Shrimp Lethality Test (BSLT) method. The results showed that the ethanol extract of bintaro leaves (Cerbera manghas) contains steroid compounds, saponins, and quinones. Furthermore, the IC50 value of the ethanol extract of bintaro leaves (C. manghas) was 41.68 ppm with a very strong category and the results of the toxicity test obtained the LC50 value of the ethanol extract of bintaro leaves (C. manghas) of 30.44 ppm with a very toxic category. An extract with an LC50 value ≤ 30 ppm has the potential as an anticancer drug candidate because of the correlation between the level of toxicity and anticancer activity so that these results can be concluded that the ethanol extract of bintaro leaves (C. manghas) has the potential to have bioactivity because it is toxic to Artemia salina L. shrimp larvae. Keywords: Antioxidant, Brine Shrimp Lethality Test (BSLT), Bintaro Leaves, Phytochemical Test
The Potential oOf Butterfly Root Plant (Phanera semibifida Roxb. var. semibifida) Stem as a Source of Antioxidants and Natural Sunscreen Agent T, Nurnaningsi; Hairani, Rita; Saleh, Chairul; Ruga, Ritbey; Marliana, Eva; Hendra, Medi
JURNAL KIMIA MULAWARMAN Vol 23 No 1 (2025)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v23i1.1559

Abstract

Phanera semibifida Roxb. var. semibifida merupakan tanaman liana yang berasal dari famili Leguminosae. Tanaman ini umum digunakan sebagai tanaman obat oleh berbagai suku bangsa di Kalimantan. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder menggunakan metode kromatografi lapis tipis (KLT), mengevaluasi aktivitas antioksidan menggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil), dan menilai potensi tabir surya secara in vitro menggunakan spektrofotometer UV-Vis. Uji fitokimia menunjukkan bahwa baik ekstrak metanol kasar maupun fraksi etil asetat mengandung alkaloid, steroid, triterpenoid, fenolik, dan flavonoid. Fraksi n-heksana mengandung steroid dan triterpenoid. Fraksi air mengandung alkaloid, fenolik, dan flavonoid. Aktivitas antioksidan diamati dalam ekstrak metanol kasar, n-heksana, etil asetat, dan fraksi air dengan nilai IC₅₀ masing-masing 19,51; 105,08; 16,99 dan 137,30 mg/L. Aktivitas tabir surya ditentukan berdasarkan nilai SPF pada konsentrasi 25, 50, 100, 150, 200, dan 250 mg/L untuk ekstrak kasar, fraksi n-heksana, etil asetat, dan air, yang masing-masing berkisar antara 0,52–6,55, 0,63–6,91, 1,51–17,93, dan 0,23–3,01. Hasil ini menunjukkan potensi Phanera semibifida Roxb. var. semibifida sebagai kandidat alami dengan aktivitas antioksidan dan sifat pelindung matahari.
Co-Authors Aditya, Adrian Maulana Chairul Saleh Erwin Erwin Eva Marliana, Eva Hairani, Rita Medi Hendra, Medi Ramadani, Andi Deffi Ruga, Ritbey