<![CDATA[Background: Previous studies showed that cardiovascular risk factor was increased in obese and overweight subjects. Obesity and cardiovascular risk factor are associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity that causes hypercortisolism, cortisol level is associated with cardiovascular risk factor on obesity. 11 ò-hydroxylase is an enzyme that involved in cortisol synthesis. The aim of this study was to investigate 11 ò-Hydroxylase concentration in obesity, overweight, and normal weight young men.Subjects and Method: This was analytic-observational study using cross-sectional design. The study was conducted at HKBP Nommensen University, Medan. The study subjects included by 76 young men aged 18-28 years old, consisting of 25 obese subjects, 25 overweight, and 25 normoweight. The concentration of 11 ò-Hydroxylase was evaluated in blood sample after 10 hours fasting. The data was analyzed bivariately.Results: Mean of 11 ò-Hydroxylase concentration was 52.76 ñ 44.27 in obese subjects, 70.16 ñ 46.83 in overweight subjects, and 43.42 ñ 27.75 in normoweight subjects. The 11 ò-Hydroxylase concentration in overweight subjects was statistically higher than normoweight subjects (p = 0.007), but the 11 ò-Hydroxylase concentration on obese subjects statistically was not different from normoweight subjects (p = 0.362).Conclusion: The 11 ò-Hydroxylase concentration on overweight subject is higher than normoweight subject. There is no difference of 11 ò-Hydroxylase concentration on obese and normoweight subject. Mitochondrial stress and mitochondrial failure mechanism on overweight and obesity merit further investigation.Keywords: 11 ò-Hydroxylase, cortisol, obesity, overweightCorrespondence:àJenny Novina Sitepu. Faculty of Medicine, HKBP Nommensen Medan University, Medan.Indonesian Journal of Medicine (2016), 1(1): 71-75https://doi.org/10.26911/theijmed.2016.01.01.09]]>
