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All Journal JBIO: jurnal biosains (the journal of biosciences) Prosiding Seminar Biologi Elkawnie Padjadjaran Journal of Dentistry Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Buletin Farmatera IJOEP : International Journal of Ecophysiology Bioscientist : Jurnal Ilmiah Biologi Archives of The Medicine and Case Reports Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik)
Syafruddin Ilyas
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Sumatera Utara
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Anticancer potency of black sea cucumber (Holothuria atra) from Mentawai Islands, Indonesia Satari, Mieke Hemiawati; Arma, Utmi; Ilyas, Syafruddin; Handayani, Dian
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.217 KB) | DOI: 10.24198/pjd.vol29no1.11654

Abstract

Introduction: The source of bioactive compounds believed to have strong anticancer potency is derived from sea cucumber. Black sea cucumber (Holothuria atra) is a dominant species in Mentawai Islands, West Sumatera, Indonesia. Key factor compound that acts as anticancer in sea cucumber extract is tritepenoid also known as Frondoside A. The purpose of this study was to determine the effectiveness of the active compound taken from black sea cucumber as anticancer. Methods: Methods used was experimental laboratory. Anticancer activity of black sea cucumber was determined by using the MTT assay cytotoxic test to measure the IC50. Cytotoxic test was conducted with Supris clone-1 (SP-C1) derived from cloned lymphadenopathy of patients with oral squamous cell carcinoma on lingual part. Results: It was found that the compounds contained in black sea cucumber has strong anticancer activity (IC50 = 5.25 μL/mL) against SP-C1. Conclusion: Black sea cucumber extract has strong cytotoxic effects against cancer cells SP-C1, therefore black sea cucumber extract potentially developed as a new source of cancer medicine.
Pengaruh Pemberian EVOO Terhadap Berat Badan Lahir Tikus Putih (Rattus norvegicus) pada Induk Model Preeklampsia Evi Irianti; Syafruddin Ilyas; Rosidah Rosidah; Salomo Hutahaen; Ramlan Silaban
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 11 (2020): Nomor Khusus Mei-Juni 2020
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf11nk314

Abstract

Pre eclampsia is believed to be caused by a missmatch of antioxidants in the body which can be prevented by the administration of EVOO. EVOO which is proved to be rich in tocopherol which plays an important role in preventing this missmatch, thus both free radicals and antioxidants are in balanced concentration, particularly during pregnancy. This study was a laboratory based pre and post test with control group design which was conducted in total of 25 pregnant female albino rats from Sprague Dawley strain with body weight of approximately 200 grams. Samples were then grouped into P0 as control group and other 4 experimental group (P1, P2, P3, P4). Experimental group was given injection of 6% sodium chloride solution as much as 3 ml/day on the 6th until 12th day of their pregnancy and was given stimulation of acute stress on day 18th to model these groups into having pre eclampsia. All these four groups were then given EVOO on day 13th to 19th, except P1. On day 20th, all samples were executed. We found that birth weight among rats within experimental groups which were given either mild or moderate dose of EVOO showed no significant difference compared to control group, 71,43% fetus was found dead in P1, and 41,94% was found in P4. Thus, we concluded that EVOO was able to suppress free radicals and we suggested that other natural antioxidants, such as GPx, GSH and vitamin E should be furtherly investigated to see how these antioxidants work in altering the lipid peroxidation process after the administration of EVOO. Keywords: EVOO; birth weight ABSTRAK Salah satu penyebab preeklampsia adalah ketidak seimbangan antioksidan di dalam tubuh dan dapat dicegah dengan pemberian EVOO. Pemberian EVOO yang kaya akan kandungan tokoferol bertujuan untuk mencegah ketidakseimbangan antara produksi radikal bebas dan antioksidan khususnya pada kondisi hamil. Rancangan penelitian ini pre and post test with control goup design di laboratorium. Subyek tikus putih betina bunting, galur Sprague Dawley, BB ±200g. Total sampel 25 ekor terdiri atas kelompok kontrol (P0) dan 4 kelompok perlakuan sebagai model preeklampsia (P1, P2, P3, P4). Model preeklampsia dilakukan dengan injeksi NaCl 6% 3 ml/hari pada hari ke 6 – 12 periode kebuntingan dan stres akut hari ke18 sekali saja. Seluruh kelompok perlakuan diberi EVOO kecuali P1, dari hari ke 13 - 19. Hari ke 20, seluruh tikus dieksekusi. BBL kelompok perlakuan yang diberi EVOO dosis rendah maupun sedang tidak beda dengan kontrol, 71,43% fetus mati pada kelompok P1, dan 41,94% pada P4. Kesimpulan EVOO mampu menekan radikal bebas dalam darah. Disarankan untuk mengukur antioksidan alami lainnya seperti GPx, GSH serta vitamin E untuk mengetahui peranan dalam mereduksi peroksida lemak setelah pemberian EVOO. Kata kunci: EVOO; berat badan lahir
Pengaruh Ekstrak Methanol Biji Pare (Momordica charantia) dan DMPA Terhadap Jumlah Sel purkinje Cerebellum Mencit (Mus musculus L.) SYAFRUDDIN ILYAS; SALOMO HUTAHAEAN; NURSAL NURSAL
Prosiding Seminar Biologi Vol 2 No 1 (2016): Prosiding Seminar Nasional From Basic Science to Comprehensive Education
Publisher : Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/psb.v2i1.3379

Abstract

Perubahan jumlah sel purkinje cerebellum mencit dapat dijadikan sebagai indikator terjadinya gangguan terhadap otak kecil pada pemberian ekstrak methanol biji pare (Momordica carantia L.) dan DMPA. Metode eksperimen digunakan untuk menentukan perbedaan yang terjadi pada tiap kelompok kontrol dan pemberian lama pemberian ekstrak biji pare dan DMPA. Kelompok kontrol terbagi dalam K0, K1, dan K2 dengan waktu berturut-turut 0, 4, dan 8 minggu. Kelompok perlakuan terdiri dari (P0) biji pare 0 minggu secara oral dan DMPA intramuskular (@ 6 jam), (P1) biji pare dan DMPA (@4 minggu), (P2) biji pare dan DMPA (@8 minggu). Masing-masing kelompok terdiri dari 5 mencit sehingga total mencit jantan adalah 30 ekor. Dosis ekstrak metanol biji pare adalah 5mg/10g berat badan mencit yang diberikan secara oral) (Yama et al. 2011). Sedangkan dosis DMPA sebesar 0,175 mg/ekor mencit yang diberikan secara intramuskular (Ilyas 2014). Hasil penelitian menunjukkan tidak adanya perbedaan yang nyata  (p>0,05) antara kontrol dan perlakuan pada 0, 4, dan 8 minggu terhadap jumlah sel purkinje cerebellum mencit. Disimpulkan bahwa pemberian ekstrak metanol biji pare dan DMPA aman terhadap perbedaan jumlah cerebellum mencit. Kata kunci: Sel purkinje, Momordica charantia L., DMPA, Mus musculus L. 
HUBUNGAN ANTARA KUALITAS AIR DENGAN KEBIASAAN MAKANAN IKAN BATAK (Tor soro) DI PERAIRAN SUNGAI ASAHAN SUMATERA UTARA Budianto Siregar; Ternala Alexander Barus; Syafruddin Ilyas
JBIO: jurnal biosains (the journal of biosciences) Vol 1, No 2 (2013): Bio
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v1i2.12508

Abstract

Telah dilakukan penelitian tentang hubungan antara kualitas air dengan kebiasaan makanan ikan batak (Tor soro) di perairan Sungai Asahan Sumatera Utara pada bulan November 2012-Januari 2013. Tujuan penelitian ini adalah untuk mengetahui kebiasaan makanan ikan batak (Tor soro), kualitas air Sungai Asahan, serta hubungan antara kualitas air dengan kebiasaan makanan ikan batak (Tor soro). Pengambilan sampel dilakukan dengan menggunakan electrofishing dan jala serta isi lambung dianalisis dengan menggunakan metode volumetrik. Hasil penelitian menunjukkan bahwa ikan batak (Tor soro)  memiliki pola pertumbuhan alometrik. Makanan utama ikan batak (Tor soro) berdasarkan Index of Preponderance: Cladophora (47,01%, 62,29%, 71,11%) pada stasiun 1, 4, dan 5. Cymbella (47,57%) pada stasiun 2, Vaucheria (51,46%) pada stasiun 3. Temperatur, Intensitas cahaya, kecerahan dan pH berkorelasi kuat terhadap Cladophora. Nitrat dan posfat berkorelasi kuat terhadap Cymbella. Nitrat berkorelasi kuat terhadap Vaucheria. Kondisi Sungai Asahan secara relatif dalam keadaan baik dan mendukung pertumbuhan ikan batak (Tor soro).
HUBUNGAN ANTARA KUALITAS AIR DENGAN KEBIASAAN MAKANAN IKAN BATAK (Tor douronensis) DI PERAIRAN SUNGAI ASAHAN SUMATERA UTARA Ria Lumbantoruan; Ternala Alexander Barus; Syafruddin Ilyas
JBIO: jurnal biosains (the journal of biosciences) Vol 1, No 2 (2013): Bio
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v1i2.12728

Abstract

Telah dilakukan penelitian tentang hubungan antara kualitas air dengan kebiasaan makanan ikan batak (Tor douronensis) di Perairan Sungai Asahan Sumatera Utara. Tujuan penelitian ini adalah untuk mengetahui kualitas air Sungai Asahan, kebiasaan makanan ikan batak (Tor douronensis) serta hubungan antara kualitas air dengan kebiasaan makanan ikan batak (Tor douronensis). Hasil penelitian menunjukkan bahwa ikan batak memiliki pola pertumbuhan alometrik. Makanan utama ikan batak berdasarkan indeks prepoderannya adalah Cymbella (56,32%), Navicula (46,65%), Thiothrix (44,25%), dan Ulothrix (76,21%). Temperatur berkorelasi kuat terhadap Thiothrix. Kecerahan berkorelasi kuat terhadap Thiothrix. Intensitas Cahaya berkorelasi sangat kuat terhadap Navicula. Arus berkorelasi kuat terhadap Navicula. Parameter pH berkorelasi sangat kuat terhadap Cymbella. DO berkorelasi kuat terhadap Navicula. BOD 5 berkorelasi kuat terhadap Navicula. NO3 berkorelasi kuat terhadap Thiothrix. PO4 berkorelasi berkorelasi kuat terhadap Thiothrix. Kondisi Sungai Asahan mengindikasikan secara relatif dalam keadaan baik dan mendukung pertumbuhan ikan batak (Tor douronensis).
HUBUNGAN ANTARA KUALITAS AIR DENGAN KEBIASAAN MAKANAN IKAN BATAK (Neolissochilus sumatranus) DI SUNGAI ASAHAN, SUMATERA UTARA Mesrawati Purba; Ternala Alexander Barus; Syafruddin Ilyas
JBIO: jurnal biosains (the journal of biosciences) Vol 1, No 2 (2013): Bio
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v1i2.12729

Abstract

The study of the water quality relationship and food habits of batak fish (Neolissochilus sumatranus) in Asahan river, North Sumatra was conducted. Aims of this research are to undesrtand the food habits of batak fish , the water quality of Asahan river and relationship between water quality and food habits of batak fish. Fish samples were caught by electrofishing and casnet and stomach content was analysis using volumetric method. Results showed that the batak fish  have allometric growth patten. Based on the data of stomach content shown that 38 organism, the major food of batak fish  based on index preponderance are Cymbella (42,56%), Navicula (56,90%) and Nitschia (47,09 %). Cymbella positively correlated with light penetration, light intensity, DO and BOD5 and negatively correlated with temperature,water current, pH, NO3 and PO4. Navicula positively correlated with water current, pH, DO, BOD5, NO3 and PO4 and negatively correlated with temperature, light penetration and light intensity. Nitzschia positively correlated with light intensity,   temperature, light penetration, pH and PO4 and negatively correlated with water current, DO, BOD5 and NO3. Indicating the condition of Asahan river is relatively in good condition and support fish growth as well
IKAN BATAK (Neolissochillus sumatranus) SEBAGAI BIOINDIKATOR PENCEMARAN LOGAM BERAT TIMBAL (Pb) DAN CADMIUM (Cd) DI PERAIRAN SUNGAI ASAHAN SUMATERA UTARA Rina Marintan Sitorus; Ternala Alexander Barus; Syafruddin Ilyas
JBIO: jurnal biosains (the journal of biosciences) Vol 1, No 2 (2013): Bio
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v1i2.12735

Abstract

Penelitian ikan batak (Neolissochillus sumatranus) sebagai bioindikator pencemaran logam berat Pb dan Cd di sungai Asahan. Pengambilan sampel dilakukan pada bulan  Januari 2013 di 5 stasiun pengamatan. Sampel yang diambil adalah ikan dan air. Parameter yang diamati adalah logam berat (Pb dan Cd), kualitas air (temperatur, arus, kecerahan dan intensitas cahaya) dan unsur hara (nitrat dan posfat). Kandungan logam berat Pb  di air (<0,01 mg/L) dan pada ikan (<0,054 mg/L)  masih di diluar batas baca untuk deteksi limit. Kandungan Cd di air berkisar antara 0,002-0,007 mg/L, nilai ini masih dibawah baku mutu air golongan I (Peraturan Pemerintah No. 82 tahun 2001), dan di air nilai Cd diluar batas baca untuk deteksi limit yaitu <0,003 mg/L. Konsentrasi logam (Pb dan Cd) di air dan ikan masih memenuhi standar baku mutu. Klasifikasi mutu air kelas IIL dengan metode storet disimpulkan bahwa setiap stasiun tergolong kualitas air kelas A kategori perairan baik sekali.  
Anticancer Activity of N-Hexane Extract from Sphagneticola trilobata (L.) J.F Pruski Against MCF-7 Breast Cancer Cell Vivi Mardina; Tisna Harmawan; Halimatussakdiah Halimatussakdiah; Syafruddin Ilyas; Masitta Tanjung
Elkawnie: Journal of Islamic Science and Technology Vol 6, No 1 (2020)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6183

Abstract

Abstract : Sphagneticola trilobata (L.) J.F. Pruski is one of the perennial herbs that is widely used by the national and international community to treat various diseases including cancer. The objective of this study was to assessment the anticancer activity of n-hexane extract of S. trilobata leaves for inhibiting the growth of MCF-7 breast cancer cells in vitro by MTT (microculture tetrazolium salt) method. The n-hexane extract of sernai leaves was obtained from the maceration process of samples that were collected from the Langsa city, Aceh. The cytotoxicity test was carried out by incubating MCF-7 cells which had been exposed to several series of sample levels, viz. 1000; 500; 100; 50; 25; 10; 5 and 1 µg/mL. LC50 values are calculated using probit analysis. The results revealed that the n-hexane extract of S. trilobata leaves was cytotoxic against breast cancer cells (MCF-7) with an LC50 value of  0.037 μg /mL.Abstrak : Sphagneticola trilobata (L.) J.F. Pruski merupakan salah satu tanaman herbal yang digunakan secara luas oleh masyarakat nasional dan internasional untuk mengobati berbagai penyakit termasuk kanker. Penelitian ini bertujuan untuk mengetahui aktivitas antikanker ekstrak n-heksana daun S. trilobata dalam menghambat pertumbuhan sel kanker payudara MCF-7 secara in vitro dengan metode MTT (microculture tetrazolium salt). Ekstrak n-heksana daun sernai diperoleh dari proses maserasi sampel yang dikoleksi dari kota Langsa, Aceh. Uji sitotoksisitas dilakukan dengan menginkubasi sel MCF-7 yang telah dipaparkan beberapa seri  kadar sampel yaitu 1000, 500, 100, 50, 25, 10, 5 dan 1 µg/mL. Nilai LC50 dihitung dengan menggunakan analisa probit. Hasil penelitian menunjukkan bahwa ekstrak n-heksana daun S. trilobata bersifat sitotoksik terhadap sel kanker payudara (MCF-7) dengan harga LC50 sebesar 0,037 µg/mL. 
EFFECTS OF METHANOL EXTRACT AND N-HEXANE EXTRACT OF PAPAYA LEAVES (CARICA PAPAYA L) ON TOTAL AND DIFFERENTIAL WHITE BLOOD CELL COUNTS IN MALE WISTAR RATS AFTER CARRAGEENAN INDUCTION Okto P.E Marpaung; Datten Bangun; Syafruddin Ilyas
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (730.05 KB) | DOI: 10.30596/bf.v4i2.3016

Abstract

As one of the countries producing medicinal plants, Indonesia has the potential to develop medicinal plants in the future. The anti-inflammatory effects of methanol and n-hexane extract from papaya leaves were seen in this study using a pretest-posttest control group design using 36 male adult Wistar rats divided into 6 groups. All rats received 1 week acclimatization, then blood specimens were taken from the tail, after which they were treated, and intraplantar injections were carried out with 1% carrageenan solution as much as 0.1 ml. Then retrieval of blood specimens from rats' tails at 3 hours and 6 hours afterwards. Then an examination of the number and type of leukocytes was performed on all blood specimens obtained. It was found that the number of male Wistar rat leukocytes after getting methanol extract of papaya leaves was lower but not significant (p> 0.05) compared to those who did not. The increase in the number of leukocytes cannot be restrained significantly by the administration of n-hexane extract. It was found that changes in leukocyte counts in acute inflammatory conditions with the administration of methanol extract and n-hexane extract of Papaya Leaves. The increase number of neutrophils and monocytes in acute inflammatory conditions can be significantly suppressed by the administration of methanol extract of papaya leaves. Key words: inflammation, carrageenan, papaya, Carica papaya l
PENGUJIAN AKTIVITAS ANTI BAKTERI DAUN Sphagneticola trilobata J.F (L.) Pruski TERHADAP Salmonella typhi DAN Escherichia coli Vivi Mardina; Syafruddin Ilyas; Tisna Hermawan
Prosiding Seminar Nasional Biotik Vol 8, No 1 (2020): PROSIDING SEMINAR NASIONAL BIOTIK VIII 2020
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh, Aceh, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (539.864 KB) | DOI: 10.22373/pbio.v8i2.9670

Abstract

Sphagneticola trilobata (L.) J.F Pruski merupakan tumbuhan semak, dianggap invasive dan mudah tumbuh pada iklim tropis. Penelitian ini bertujuan untuk mengevaluasi aktivitas antibakteri ekstrak n-heksana dan etil asetat dari daun S. trilobata terhadap bakteri patogen, Salmonella typhi dan Eschericia coli. Metode difusi sumuran diadopsi dengan konsentrasi ekstrak bervariasi dari 0,5-10% (b/v). Hasil uji aktivitas antibakteri memaparkan bahwa ekstrak etil asetat lebih potensial/aktif menghambat pertumbuhan bakteri S. typhi dan E. coli  dengan zona inhibisi yang dihasilkan masing-masing pada range 12-17 mm dan 11-19 mm.  Adapun ekstrak n-heksana daun S. trilobata dikategorikan lemah aktivitas antibakterinya dengan zona inhibisi yang dihasilkan pada range 3,6-6,8 mm dan 4,3-6 mm masing-masing terhadap S. typhi dan E. coli. Berdasarkan uji aktivitas antibakteri maka penelitian ini menyimpulkan bahwa ekstrak etil asetat daun S. trilobata (L.) J.F Pruski berpotensial untuk dijadikan agen baru antibakteri sehingga purifikasi ekstrak sangat dianjurkan.
Co-Authors Anggraini, Dwi Rita Antika, Maya Anjelir Ashfira Asmarinah Asmarinah Budianto Siregar Datten Bangun Dearni Damanik Dharma Lindarto Dian Handayani Endy Juli Anto Evi Irianti fatchiyah . Fauzi Yusuf, Fauzi Hadyanto L Halimatussakdiah Halimatussakdiah Harry Agusnar Harun Al Rasyid Ira Cinta Lestari Jekson M. Siahaan Kesuma Wardani Lestari, Chandra Marpaung, Okto P.E Masitta Tanjung Mesrawati Purba Mieke Hemiawati Satari Nukman Moeloek Nurjati C. Siregar Nursal Olivia Avriyanti Hanafiah Polem, Wardah Sawitri Ramlan Silaban Ria Lumbantoruan Rina Marintan Sitorus Rosidah, Rosidah Salomo Hutahaean Salomo Hutahaen Sari, Mutiara Indah Silvia W Lestari Sinaga, Ade Putra Fratama Siregar C Siregar, Siregar C Suryani Eka Mustika Teguh Firdaus Ternala Alexander Barus Tisna Harmawan Tisna Hermawan Tri Widyawati Utmi Arma, Utmi Vivi Mardina Vivi Mardina Yasmeini Yazir