Computational thinking ability is one of the important skills in today's digital era. In the context of education, the development of computational thinking ability can be done through various learning tools and applications that support a technology-based approach. A tool that can be used to analyze and train computational thinking ability is Microsoft WIRIS Quizzes. This study aims to analyze the effect of using Microsoft WIRIS Quizzes in managing students' computational thinking ability, especially in the context of mathematics and science learning. This study uses a quantitative method with an experimental design involving students from several high schools in Indonesia. The findings of this study indicate that the implementation of Microsoft WIRIS Quizzes substantially improves students' computational thinking ability, as well as supports students in understanding mathematics and science concepts with more interactive methods.