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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Griya Widya: Journal of Sexual and Reproductive Health
Saraswati, Benedikta Diah
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Impact of Intermittent Fasting on Genes Involved in Neurodegenerative Diseases Siregar, Rizky Amalia; Saraswati, Benedikta Diah
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 12 No. 1 (2025): Jurnal Kesehatan (April 2025)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v12i1.817

Abstract

Neurodegenerative diseases, characterized by progressive neuron loss, present a significant global health challenge. Recent research highlights the role of genetic expression in these diseases, with lifestyle interventions, such as dietary changes, shown to influence gene expression linked to neurodegeneration. One promising approach is intermittent fasting (IF), a dietary method alternating fasting and eating periods, which affects biological processes like cellular repair, inflammation, and metabolism. Emerging evidence suggests IF may also alter gene expression related to neurodegenerative diseases, potentially reducing risk and slowing progression. This review examines current studies on the impact of IF on gene expression in neurodegeneration, exploring its mechanisms and implications for new therapeutic and preventive strategies.
Melatonin’s Role in Female Fertility: Molecular Insights and Therapeutic Implications Saraswati, Benedikta Diah
Griya Widya: Journal of Sexual and Reproductive Health Vol. 5 No. 1 (2025): Griya Widya: Journal of Sexual and Reproductive Health
Publisher : Nur Science Institute and Perkumpulan Keluarga Berencana Indonesia (PKBI) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53088/griyawidya.v5i1.1886

Abstract

Background: This narrative review examines how melatonin enhances reproductive health functions. Melatonin has established itself as a multifaceted neurohormone with pivotal roles in female reproductive health. Through its potent antioxidant properties, melatonin protects oocytes and orchestrates hormonal regulation and ovarian function, with melatonin receptors strategically located in key reproductive tissues, including ovarian granulosa and luteal cells. Method: This narrative review examines how melatonin preserves and enhances female fertility by analyzing clinical outcomes and molecular pathways. It compiles research on the effects of melatonin on ovarian function, oocyte quality, hormone regulation, and assisted reproductive technologies from major databases published between 2015 and 2025. The study consistently shows how melatonin works and its potential benefits, offering broad insights without strict limits. Result: Melatonin operates through multiple receptor-mediated pathways to regulate reproductive functions. Clinical evidence shows melatonin supplementation improves assisted reproductive technology (ART)’s success rates by enhancing oocyte maturation and embryo quality, restoring menstrual regularity in PCOS patients, and protecting reproductive tissues from oxidative stress-induced damage. Implication: These findings support melatonin's therapeutic potential in assisted reproductive technologies and treating reproductive disorders. Healthcare providers should consider melatonin supplementation as an adjuvant therapy for women undergoing fertility treatments or experiencing reproductive dysfunction while establishing standardized protocols for optimal dosing and timing. Novelty: This comprehensive review reveals melatonin's multifaceted role as a fertility regulator, providing molecular insights into its therapeutic mechanisms and clinical applications in women's reproductive health across the reproductive lifespan
Peran Polimorfisme Gen ADIPOQ terhadap Risiko Obesitas: Tinjauan Literatur Sistematis Saraswati, Benedikta Diah
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 4 (2026): Volume 13 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i4.21587

Abstract

Obesitas merupakan masalah kesehatan global yang dipengaruhi oleh interaksi kompleks antara faktor genetik dan lingkungan. Salah satu faktor genetik utama yang berperan adalah polimorfisme pada gen adipokin, khususnya ADIPOQ, yang mengodekan hormon adiponektin. Tinjauan literatur sistematis ini, menggunakan pendekatan PRISMA dengan 21 artikel yang disertakan dari total 189 artikel yang diidentifikasi, menyoroti peran penting polimorfisme gen ADIPOQ dalam patogenesis obesitas dan fenotipe terkait obesitas, dengan menelaah artikel terpilih dari PubMed, Google Scholar, dan Scopus periode 2015–2025. Hasil kajian menunjukkan bahwa variasi genetik seperti rs266729, rs1501299, rs822396, rs2241766, rs17300539, dan rs182052 pada gen ADIPOQ secara signifikan berhubungan dengan penurunan kadar adiponektin, peningkatan risiko obesitas, dan fenotipe terkait obesitas di berbagai populasi. Perbedaan efek polimorfisme antar populasi menegaskan pentingnya pendekatan personal dan berbasis bukti genetik dalam pencegahan serta pengelolaan obesitas, sekaligus mendorong perlunya penelitian lebih lanjut pada populasi Indonesia untuk memperkaya pemahaman lokal dan strategi penanganan yang lebih efektif.
Co-Authors Siregar, Rizky Amalia