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All Journal Media Ilmu Kesehatan Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan
Siregar, Rizky Amalia
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Health Professions Medicine & Pharmacology Nursing Public Health

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Impact of Intermittent Fasting on Genes Involved in Neurodegenerative Diseases Siregar, Rizky Amalia; Saraswati, Benedikta Diah
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 12 No. 1 (2025): Jurnal Kesehatan (April 2025)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v12i1.817

Abstract

Neurodegenerative diseases, characterized by progressive neuron loss, present a significant global health challenge. Recent research highlights the role of genetic expression in these diseases, with lifestyle interventions, such as dietary changes, shown to influence gene expression linked to neurodegeneration. One promising approach is intermittent fasting (IF), a dietary method alternating fasting and eating periods, which affects biological processes like cellular repair, inflammation, and metabolism. Emerging evidence suggests IF may also alter gene expression related to neurodegenerative diseases, potentially reducing risk and slowing progression. This review examines current studies on the impact of IF on gene expression in neurodegeneration, exploring its mechanisms and implications for new therapeutic and preventive strategies.
Hubungan Konsep Diri dengan Ketangguhan Psikologis pada penderita Diabetes Mellitus Siregar, Rizky Amalia; Purba, Anna Wati Dewi
MEDIA ILMU KESEHATAN Vol 14 No 2 (2025): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v14i2.1724

Abstract

Background: Chronic diseases such. as heart. disease, cancer, stroke, and diabetes mellitus. not only affect physical health but also impose a substantial psychological burden.Objective: This study aimed to analyze the relationship. between self-concept and psychological hardiness among patients with chronic diseases at RSUD Dr. Pirngadi Medan.Methods: A quantitative correlational design was employed with 384 respondents selected through consecutive sampling. The instruments used were a self-concept scale based on Fitts’ theory and a psychological hardiness scale based on Maddi’s theory, both in the form of Guttman scales. Data analysis included validity, reliability, normality, linearity tests, and Pearson Product Moment correlation using SPSS version 25.Results: results showed a very strong and statistically significant positive correlation between self-concept and psychological hardiness (r = 0.814; p < 0.01). The empirical mean score of self-concept was 50.29 compared to the hypothetical mean of 30.50, while the empirical mean score of hardiness was 29.30 compared to the hypothetical mean of 17.00.Conclusion: A positive self-concept contributes to the enhancement of psychological hardiness, supporting therapy success and improving patients’ quality of life. Clinical implications highlight the importance of integrating psychosocial interventions to strengthen self-concept as part of holistic care for chronic disease patients.
Co-Authors Anna Wati Dewi Purba Saraswati, Benedikta Diah