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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. The International Journal of Medical Science and Health Research
Abdul Mubdi Ardiansar Arifuddin Karim
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Vitamin D Supplementation Compared With Inhalation Therapy In Asthma Patients: A Meta-Analysis Using Revman Alifah Raihan Fadilla; Imran Safei; Abdul Mubdi Ardiansar Arifuddin Karim
The International Journal of Medical Science and Health Research Vol. 14 No. 1 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/frtfrb79

Abstract

Introduction: Asthma is a chronic inflammatory disease of the airways that remains difficult to control despite the availability of standard therapies such as inhaled corticosteroids (ICS). The role of vitamin D as an immunomodulator with anti-inflammatory properties has attracted attention as a potential adjunctive therapy. Several studies have reported an association between vitamin D deficiency and increased asthma severity. This study aims to compare the effectiveness of vitamin D supplementation and inhalation therapy in controlling asthma symptoms. Methods: This meta-analysis was conducted in accordance with PRISMA guidelines. A systematic search was performed in PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov. Included studies were randomized controlled trials (RCTs) evaluating the effect of either vitamin D supplementation or inhalation therapy on the Asthma Control Test (ACT) score. Data were analyzed using a random-effects model in Review Manager 5.2, with effect sizes presented as Standardized Mean Differences (SMD). Results: A total of 11 studies were included (6 on vitamin D, 5 on inhalation therapy). Vitamin D supplementation showed a pooled SMD of 0.54 (95% CI: 0.25–0.84; p = 0.0003), indicating a moderate effect, with high heterogeneity (I² = 93%). Studies by Tuba Çiftçi (2019) and Rubén Andújar-Espinosa (2020) reported large effects (SMD > 1), while Adrian (2015) showed no significant effect. Inhalation therapy produced more variable outcomes; Belachew (2022) showed the largest effect (SMD = 1.32), while studies such as Boonsawat (2015) and Kondla (2016) reported small or nonsignificant effects. Overall, vitamin D showed a more consistent and generally greater effect compared to inhalation therapy. Conclusion: Vitamin D supplementation appears to be an effective adjunctive therapy for improving asthma control, particularly in patients with vitamin D deficiency. Further large-scale RCTs are needed to determine optimal dosing, duration, and the most responsive patient subgroups.
Systematic Review with Revman Method: Comparison of Creatinine Levels with Cystatin-C in Identifying CKD in Hypertension Patients Siti Anisah Azzahra Rasmin; Abdul Mubdi Ardiansar Arifuddin Karim; Muhammad Rasyidi Juhamran
The International Journal of Medical Science and Health Research Vol. 14 No. 3 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/6yfxq676

Abstract

Background: Chronic kidney disease (CKD) is a serious complication frequently associated with hypertension. Early and accurate evaluation of kidney function is essential to prevent disease progression. Serum creatinine is commonly used to estimate glomerular filtration rate (eGFR), but its diagnostic accuracy is limited. Cystatin-C has emerged as a more sensitive and specific biomarker for detecting renal dysfunction, especially in high-risk populations such as hypertensive patients. Objective: To evaluate and compare the diagnostic accuracy of serum creatinine and cystatin-C in identifying CKD among hypertensive patients through a systematic review and meta-analysis. Methods: This systematic review followed the PRISMA guidelines and included studies retrieved from PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov. Quantitative data from 10 eligible studies were analyzed using Review Manager (RevMan) version 5.2. The primary outcomes included differences in eGFR values based on cystatin-C and creatinine, as well as diagnostic measures such as sensitivity, specificity, and area under the curve (AUC). Results: Analysis of 10 studies involving 8,554 hypertensive patients indicated that eGFR based on cystatin-C tends to yield lower estimates of kidney function compared to creatinine-based eGFR (Standardized Mean Difference [SMD] = –0.24; p = 0.12). This suggests a potential for earlier detection of kidney impairment, although the difference was not statistically significant. The majority of studies reported that cystatin-C had a higher area under the curve (AUC) and was more accurate in reclassifying CKD stages compared to creatinine. Conclusion: Cystatin-C offers superior diagnostic and predictive performance compared to creatinine in detecting CKD among hypertensive patients, especially in early detection and disease classification. Its selective use in high-risk populations is recommended to enhance diagnostic accuracy and improve clinical decision-making.
Relationship between Uric Acid Level and Hypertension Incidence in Takkalasi Village, Barru Regency Sri Rahayu Jamaluddin; Andi Dhedie Prasatia Sam; Zulfahmidah; Irna Diyana Kartika; Abdul Mubdi Ardiansar Arifuddin Karim
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 21 No. 1 (2025): June 2025
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol21.SMUMM1.39921

Abstract

Introduction: Hypertension is one of the major risk factors for cardiovascular disease that causes high morbidity and mortality globally. The prevalence of hypertension continues to increase, including in Indonesia, including Barru Regency with a high incidence rate. One factor that is thought to play a role is high uric acid levels or hyperuricemia. Hyperuricemia can trigger activation of the renin-angiotensin-aldosterone system and oxidative stress, which contribute to increased blood pressure. Several studies have shown a close relationship between uric acid levels and the incidence of hypertension. Therefore, this study aims to analyze the relationship between uric acid levels and the incidence of hypertension in Takkalasi Village, Barru Regency. Methods: This type of research is a cross sectional study approach with a sampling technique, namely purposive sampling with a total of 23 samples each in the hyperuricemia group and non-hyperuricemia group so that the total sample is 46 samples. The research data is primary data taken directly in August - September 2024 in Takkalasi Village, Barru Regency which was then analyzed using the chi square test. Research Results: It was found that non-hyperuricemia respondents who suffered from hypertension were 21.7% and hyperuricemia sufferers who experienced hypertension were 32.6%. The chi square test that has been carried out shows a value of p=0.0139 (p>0.005). Conclusion: Uric acid levels are not significantly associated with hypertension. Even so, people are still asked to maintain a healthy lifestyle.
Characteristics of Drug Therapy in Hemorrhoid Patients at Ibnu Sina Hospital, Makassar Feri Ramadan; Berry Erida Hasbi; Suci Noviyanah Anshary; Azis Beru Gani; Abdul Mubdi Ardiansar Arifuddin Karim
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 21 No. 2 (2025): December 2025
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol21.SMUMM2.42451

Abstract

Hemorrhoids are a common anorectal disorder, with management depending on severity and clinical features. This study aimed to describe the characteristics of pharmacological therapy in hemorrhoid patients at Ibnu Sina Hospital, Makassar. A descriptive cross-sectional study was conducted on 43 patients from January to December 2024 using total sampling. Data were collected through interviews and medical records, then analyzed descriptively. Most patients were aged 36–45 years (27.9%) and male (58.1%). Conservative management was predominant, while surgery was performed in advanced cases. The most common single therapy was oral anti-hemorrhoids (9.3%), while the most frequent combination was anti-hemorrhoids plus analgesics (16.3%). Active substances included diosmin–hesperidin (60.5%) as anti-hemorrhoids, ibuprofen and ketorolac (18.6% each) as analgesics, ceftriaxone and cefuroxime (9.3%) as antibiotics, lactulose (18.6%) as laxatives, and tranexamic acid (46.5%) as antifibrinolytic. In conclusion, hemorrhoids were more common in middle-aged males. Conservative management remained the main approach, with diosmin–hesperidin as the most widely used pharmacological therapy. Keywords: Hemorrhoid, pharmacological therapy, conservative
Co-Authors Alifah Raihan Fadilla Andi Dhedie Prasatia Sam Azis Beru Gani Berry Erida Hasbi Feri Ramadan Imran Safei Irna Diyana Kartika Muhammad Rasyidi Juhamran Siti Anisah Azzahra Rasmin Sri Rahayu Jamaluddin Suci Noviyanah Anshary Zulfahmidah