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All Journal International Journal of Integrated Health Sciences
Sah, Sumesh Prasad
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Health Professions

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Thyroid Profile and Serum Lipid Level in Women with Normal Pregnancy Kumar, Raj; Kumar, Sudeep; Arora, Manisha; Kumar, Dinesh; Sah, Sumesh Prasad; Sharma, Shivani
International Journal of Integrated Health Sciences Vol 11, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v11n2.3460

Abstract

Objective: To evaluate the changes in thyroid profile and serum lipid level in normal pregnancy.Methods: This observational study was conducted at the Department of Biochemistry of Santosh Medical College, Ghaziabad, UP, India, from June 2021 to February 2022. In this study, 200 average pregnant women were enrolled. The thyroid profile was estimated using the ELISA method, and the lipid profile was measured using the enzymatic kit method. All data were expressed as means and standard deviations, and SPSS version 17 was used for statistical analysis.Results: This observational study observed that the mean T3, T4, and TSH levels increased significantly in the second trimester compared to the first trimester. In contrast, the mean value of T3, T4, and TSH decreased in the third trimester as compared to the second trimester. The mean levels of total cholesterol, triglyceride, and LDL-cholesterol increased significantly, while the mean value of HDL-cholesterol decreased significantly in the second and third trimesters when compared to the first trimester.Conclusion: This study demonstrated abnormal lipid and thyroid metabolism. Changes in thyroid profile may be associated with adverse obstetric outcomes. The altered lipid parameters, mainly High TG and low HDL-C concentrations, may promote vascular dysfunction and oxidative stress.
Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress Sah, Sumesh Prasad; Sah, Sonu; Kumar, Sudeep; Arora, Manisha; Kumar, Dinesh; Kumar, Raj
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.4099

Abstract

Background: Hypothyroidism is frequently associated with anemia and oxidative stress, necessitating exploration of biomarkers like Osteopontin to better understand disease mechanisms.Objective: To explore the association between Osteopontin, oxidative stress, and antioxidant capacity in hypothyroid woman with or without anemia.Methods: The study was conducted at the Santosh Medical College Department of Biochemistry in Ghaziabad, India, from September 2019 to October 2021. This study was cross-sectional and recruited 360 female subjects, divided into three groups: hypothyroidism with anemia, hypothyroidism without anemia, and normal healthy controls. Osteopontin, thyroid profile, malondialdehyde (MDA) and total antioxidant capacity were measured.Results: Osteopontin, T3, T4, and total antioxidant capacity levels were significantly lower (p<0.001), and the TSH and MDA levels significantly increased (p<0.001) in female subjects experiencing hypothyroidism, with or without anemia, as compared to normal healthy female control groups. Osteopontin demonstrated significant negative relationship with TSH and MDA, while showing a significant positive relationship with T3, T4, and total antioxidant status in both studied groups.Conclusion: Osteopontin and oxidative stress/antioxidant status significantly correlate in female subjects experiencing hypothyroidism, with or without anemia. In these patients, Osteopontin might be a useful biomarker for evaluating antioxidant levels and oxidative stress.
Impact of Nutrition Education on Dietary Habits among Bachelor-in-Medicine, Bachelor-in-Surgery (MBBS) Students: A Study in an Indian Medical College Kumar, Sudeep; Sah, Sumesh Prasad; Kumar, Dinesh; Arora, Manish; Sharma, Shiwani
International Journal of Integrated Health Sciences Vol 13, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n2.4309

Abstract

Background: Unhealthy eating patterns, often triggered by academic pressures and erratic schedules, can negatively impact students’ health and hinder their ability to effectively guide future patients. Nutrition education offers a valuable opportunity to promote healthier eating habits by providing critical knowledge that supports both students’ personal wellbeing and professional competence.Objective: To evaluate the effect of nutrition education on eating habits of first-year Bachelor-in-Medicine, Bachelor-in-Surgery (MBBS) among medical students.Methods: A pre-post interventional study was carried out on 200 Phase-1 MBBS students of Muzaffarnagar Medical College between January and June 2024. Initial dietary habits were assessed using a validated questionnaire. A structured session of nutrition education was provided. The dietary habits were then re-assessed after four weeks, and changes were analyzed using paired statistical tests.Results: Data collected after the intervention showed notable enhancements in dietary practices. The percentage of students consuming three balanced meals a day increased from 32% to 68% (p < 0.001). The intake of fast food decreased from 65% to 35%, and the consumption of sugar-sweetened beverages fell from 58% to 30%. The average servings of fruits and vegetables consumed daily rose from 2.1 to 4.5 (p < 0.01). Nutrition knowledge scores presented a 30% improvement, indicating greater awareness.Conclusion: Medical students' eating habits are much improved by nutrition education, underscoring its significance in medical education. Future healthcare workers may benefit from lifelong good eating habits if such programs are incorporated into the curriculum, which would improve patient care and their own health.
Co-Authors Arora, Manisha Dinesh Kumar Kumar, Sudeep Manish Arora Raj Kumar Sah, Sonu Sharma, Shivani Sharma, Shiwani