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All Journal Universa Medicina Medika Kartika : Jurnal Kedokteran dan Kesehatan
Leonarto, Enrico
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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MANFAAT AEROBIC EXERCISE TERHADAP KADAR BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) PADA STROKE SURVIVOR: SEBUAH TINJAUAN SISTEMATIS Sudarsono, Nani Cahyani; Hidayat, Mumtaz Maulana; Deasy, Gusti Ayu Sinta; Sanjaya, Ryan Maika; Leonarto, Enrico
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 2 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Gangguan kognitif sering terjadi pada penyintas stroke, berdampak besar pada kualitas hidup. Aerobic exercise terbukti dapat meningkatkan kadar Brain-Derived Neurotrophic Factor (BDNF), protein penting untuk neuroplastisitas, fungsi kognitif, dan pemulihan motorik. Kajian ini menggunakan tinjauan sistematis pada PubMed®, Cochrane®, ScienceDirect®, dan hand search dengan kriteria inklusi: penyintas stroke yang mendapat aerobic exercise, pengukuran BDNF, dan studi eksperimental. Hasil menunjukkan latihan aerobik intensitas tinggi secara signifikan meningkatkan BDNF dibandingkan intensitas sedang, rendah, atau latihan lain. Peningkatan BDNF berkorelasi positif dengan perbaikan fungsi kognitif, motorik, dan neuroplastisitas, menjadikan BDNF biomarker potensial dalam evaluasi rehabilitasi pascastroke. Latihan intensitas tinggi mendukung neuroplastisitas melalui peningkatan aliran darah otak, metabolisme oksigen, dan neurogenesis. Aerobic exercise, terutama intensitas tinggi, efektif meningkatkan BDNF, neuroplastisitas, dan fungsi kognitif serta motorik pada penyintas stroke. Temuan ini mendukung integrasi latihan aerobik intensitas tinggi dalam program rehabilitasi stroke untuk meningkatkan pemulihan dan kualitas hidup pasien. Kata Kunci: aerobic exercise, Brain-Derived Neurotrophic Factor (BDNF), neuroplastisitas, rehabilitasi pascastroke, stroke DOI : 10.35990/mk.v8n2.p174-184
Release of retromalleolar flexor retinaculum and combined flexor digitorum longus and flexor hallucis longus Z-plasty in checkrein deformity: a case report Irianto, Komang Agung; Leonarto, Enrico; Handoyo, Henry Ricardo
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.368-373

Abstract

BackgroundCheckrein deformity is a rare abnormality comprising flexor hallucis longus (FHL) tendon entrapment in the posterior foot due to post-traumatic or ischemic retraction of the FHLtendon following soft tissue trauma. The diagnosis is essentially clinical, but complemented by imaging to rule out unrecognized causes and evaluate the fracture healing process. This case report is the first Indonesian study to describe release of the flexor retinaculum and Z-plasty (lengthening) of flexor digitorum longus (FDL) and FHL tendons through a medial retromalleolar approach to repair the deformity. Case DescriptionWe present the case of a 51-year-old male who complained of clawing of his right first and second toes. The interest of this study lies in the fact that this patient had never experienced ankle or distal tibial fractures, only a trivial injury two years back when the patient kicked a stone at work and had a bruise on his right second toe with no fracture. Exploration of FHL tendons was performed at the level of the midfoot. The patient was planned for surgery with a medial retromalleolar ankle approach, which facilitates the release of the flexor retinaculum, in conjunction with a Z-tenotomy on the FHL and FDL tendons. ConclusionA correction was achieved, and two months post-surgery there were no recurrences of the deformity. However, this surgical procedure requires more cases to support an evaluation of its effectiveness. We suggest that exploration at the ankle and midfoot should be the primary surgical intervention in similar cases of checkrein deformity.
Co-Authors Deasy, Gusti Ayu Sinta Handoyo, Henry Ricardo Hidayat, Mumtaz Maulana Komang Agung Nani Cahyani Sudarsono Nani Cahyani Sudarsono Sanjaya, Ryan Maika