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All Journal Jurnal Multidisiplin Sahombu Jurnal Pengabdian Masyarakat dan Riset Pendidikan
Camelia Dwiyanti Prasetya
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Arts Humanities Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Other

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Potential of Natural Compounds and Biological Products as HMG-CoA Reductase Enzyme Inhibitors: a Literature Study Annisa Zahra Rahmayati; Andrey Kusuma Maulana; Aulia Zahra Annabilah; Ayu Paramitha Salsabilla; Camelia Dwiyanti Prasetya; M. Iqbal Rhamadianto
Jurnal Multidisiplin Sahombu Vol. 5 No. 5 (2025): Jurnal Multidisiplin Sahombu, July - August (2025)
Publisher : Sean Institute

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Abstract

HMG-CoA Reductase is a primary target in hypercholesterolemia therapy due to its role in cholesterol biosynthesis in the liver. This study aims to review the potential of natural substances, microbes, and in silico approaches in identifying HMG-CoA Reductase inhibitor compounds. The review was conducted on 10 national and international journals using methods such as molecular docking, enzymatic activity analysis, in silico toxicity validation, and epidemiological studies. The results show various compounds from plants such as Piper crocatum, Allium sativum, Syzygium polyanthum, as well as fermented products like Lactobacillus acidophilus have high potential as inhibitors of this enzyme. Combination therapy, modification of statin compounds, and educational approaches for patients also contribute to the effectiveness of cholesterol therapy.
Optimalisasi Lubang Resapan Biopori dalam Mendukung Ketahanan Lingkungan di Desa Singajaya Melalui Program KKN: Pengabdian Fikfik Taufik; Farid Fahrezi; Camelia Dwiyanti Prasetya; Indri Oktaviani; Michael Satrio Ibrahim; Nadia Azzahra Fadhilah; Mohammad Faisal Asssyiq; Monica Julieta; Nela Sopiani; Regita Cahyani Maulana; Indallah Mazaya Salamah
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.2535

Abstract

Community Service Program (KKN) is a curriculum program that gives students the opportunity to apply knowledge, think critically, and gain practical experience within the community. The KKN program in Singajaya Village, West Bandung Regency, was conducted to address environmental issues, particularly regarding organic waste management and waterlogging. Initial observations revealed that the community did not fully understand the benefits and application of biopore infiltration holes. Using a qualitative method, students from Universitas Muhammadiyah Bandung conducted a socialization and implementation of biopore infiltration holes (LRB) as a simple, economical, and environmentally friendly solution. As a result, the program successfully increased community awareness about organic waste management. LRB was proven effective in converting waste into compost, reducing waste accumulation, and preventing waterlogging, which in the long run can help prevent flooding. The program received a positive response, and the community hopes that LRB can be more widely implemented to ensure environmental sustainability in the village.
Co-Authors Andrey Kusuma Maulana Annisa Zahra Rahmayati Aulia Zahra Annabilah Ayu Paramitha Salsabilla Farid Fahrezi Fikfik Taufik Indallah Mazaya Salamah Indri Oktaviani M. Iqbal Rhamadianto Michael Satrio Ibrahim Mohammad Faisal Asssyiq Monica Julieta Nadia Azzahra Fadhilah Nela Sopiani Regita Cahyani Maulana