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All Journal Jurnal Multidisiplin Sahombu Jurnal Pengabdian Masyarakat dan Riset Pendidikan
Ayu Paramitha Salsabilla
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Arts Humanities Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Other

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Potential of Natural Compounds and Biological Products as HMG-CoA Reductase Enzyme Inhibitors: a Literature Study Annisa Zahra Rahmayati; Andrey Kusuma Maulana; Aulia Zahra Annabilah; Ayu Paramitha Salsabilla; Camelia Dwiyanti Prasetya; M. Iqbal Rhamadianto
Jurnal Multidisiplin Sahombu Vol. 5 No. 5 (2025): Jurnal Multidisiplin Sahombu, July - August (2025)
Publisher : Sean Institute

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HMG-CoA Reductase is a primary target in hypercholesterolemia therapy due to its role in cholesterol biosynthesis in the liver. This study aims to review the potential of natural substances, microbes, and in silico approaches in identifying HMG-CoA Reductase inhibitor compounds. The review was conducted on 10 national and international journals using methods such as molecular docking, enzymatic activity analysis, in silico toxicity validation, and epidemiological studies. The results show various compounds from plants such as Piper crocatum, Allium sativum, Syzygium polyanthum, as well as fermented products like Lactobacillus acidophilus have high potential as inhibitors of this enzyme. Combination therapy, modification of statin compounds, and educational approaches for patients also contribute to the effectiveness of cholesterol therapy.
Strategi Kolaboratif Mahasiswa dan Masyarakat dalam Mewujudkan Desa Sehat, Bersih, dan Mandiri Ekonomi: Pengabdian Adhitya Muhdan Hadiyan K; Andrea Difa Medina; Indra Budi Jaya; Ayu Paramitha Salsabilla; Desy Rizki Trihapsari; Fikruka Fityatun Fauziah; Fadillah Robani; Muhammad Dendy Anugerah; Nur Fitriyanti Azzahra; Shalu Syafa Islami H. Y; Syifa Aulia Putri
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.2442

Abstract

The Community Service Program (KKN) of Universitas Muhammadiyah Bandung in 2025 was conducted in Jambudipa Village, Cisarua District, West Bandung Regency. The program aimed to raise public awareness of health, promote better environmental management, and strengthen Micro, Small, and Medium Enterprises (MSMEs) in obtaining business legality. The methods included observation, surveys, discussions, socialization, training, mentoring, and monitoring carried out over one month, from August 6 to September 6, 2025. The results showed improved community knowledge regarding stunting prevention, the role of integrated health posts, and access to free medical services. In environmental aspects, the community began practicing waste segregation and applying biopore technology to manage organic waste. In the economic sector, MSME actors received assistance in obtaining Business Identification Numbers (NIB) and free halal certification. In conclusion, this program contributes to building a healthy, clean, and economically independent village through collaborative approaches between students, village authorities, and the community. Program sustainability through continuous mentoring and support is essential to ensure that the outcomes serve as a foundation for Jambudipa Village’s long-term sustainable development.
Co-Authors Adhitya Muhdan Hadiyan K Andrea Difa Medina Andrey Kusuma Maulana Annisa Zahra Rahmayati Aulia Zahra Annabilah Camelia Dwiyanti Prasetya Desy Rizki Trihapsari Fadillah Robani Fikruka Fityatun Fauziah Indra Budi Jaya M. Iqbal Rhamadianto Muhammad Dendy Anugerah Nur Fitriyanti Azzahra Shalu Syafa Islami H. Y Syifa Aulia Putri