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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Asian Journal of Social and Humanities
Mochtar, Fransiska
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Humanities Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Social Sciences Other

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Administration of Corosolic Acid Decreased MDA, HMG-CoA, Through Increased Leptin and GLP-1 Levels in Obese Male Rats Mochtar, Fransiska; Pangkahila, Wimpie I.; Dewi, I Gusti Ayu Sri Mahendra; Saraswati, Made Ratna; Azizah, Norma Nur Azizah
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.204

Abstract

Obesity is a condition where excessive fat is accumulated, which poses a health risk. Several treatments for obesity have been carried out, ranging from lifestyle adjustments to medication to surgery. Corrosolic acid (CA) is a natural compound that has the potential to act as an obesity agent through many mechanisms, including through reactive oxygen species (ROS). This study aims to prove that CA can reduce MDA levels and HMG-CoA reductase levels and increase leptin levels and GLP-1 levels in male Wistar rats with obesity. Wistar obese rats were orally treated with CA compound induction at a dose of 10 mg/Kg BW. MDA, HMG-CoA reductase, leptin and GLP-1 levels were examined using serum and plasma from mice in both groups of mice before and after treatment, using the ELISA method. CA to the treatment group can reduce the body weight of rat MDA levels significantly at p<0.0001, HMG-CoA reductase levels significantly at p<0.0001 and increase leptin and GLP-1 levels significantly at p<0.0001. CA's mechanism for treating obesity is through the ROS mechanism because CA has antioxidant levels that can capture free radicals in the body.CA has been proven to be an alternative drug in treating obesity by reducing body weight, MDA, and HMG-CoA levels and increasing leptin and GLP-1 levels in obese Wistar rats.
Penapisan Senyawa Fitokimia dan Aktivitas Antioksidan Daun Bidara (Ziziphus Mauritiana) Mochtar, Fransiska
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i7.61113

Abstract

Ziziphus mauritiana leaves have traditionally been used to treat various ailments, particularly those related to inflammation and infection. This therapeutic potential is presumed to be associated with its content of bioactive compounds exhibiting antioxidant activity. This study aimed to identify secondary metabolites and evaluate the antioxidant activity of Z. mauritiana leaf extract. Phytochemical screening was conducted using specific reagent methods, while antioxidant activity was measured using the DPPH radical scavenging assay. The results revealed the presence of alkaloids, flavonoids, steroids, tannins, and saponins, with saponins being the most abundant (89.8%). The extract also showed considerable levels of flavonoids (12.8%) and phenolics (9.72%), contributing to its antioxidant potential. The DPPH assay indicated a concentration-dependent increase in inhibition, with an IC₅₀ value of 92.58 µg/mL, suggesting moderate to strong antioxidant activity. These findings highlight the potential of Z. mauritiana leaf extract as a natural source of bioactive compounds for the development of phytopharmaceutical products.
Studi In Siliko dan In Vitro Senyawa Flavonoid Ekstrak Air dan Ekstrak Etanol Daun Bidara (Ziziphus Mauritiana) Sebagai Antibakteri Mochtar, Fransiska
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i2.63946

Abstract

Resistensi antibiotik terhadap Escherichia coli dan Staphylococcus aureus menjadi masalah serius kesehatan global. Daun bidara (Ziziphus mauritiana) mengandung flavonoid, seperti luteolin dan hyperoside, yang berpotensi sebagai agen antibakteri alami. Ekstrak daun bidara diperoleh dengan maserasi menggunakan air dan etanol 75%. Aktivitas antibakteri diuji dengan metode difusi cakram terhadap E. coli dan S. aureus. Uji in silico dilakukan menggunakan molecular docking (Autodock Tools) terhadap protein DNA gyrase subunit B (E. coli, PDB ID: 6F86) dan PBP2a (S. aureus, PDB ID: 6MRR). Validasi grid box ditentukan berdasarkan nilai RMSD ligan asli ≤ 2 Å. Uji in vitro menunjukkan ekstrak etanol menghasilkan zona hambat 14–18 mm (kategori sedang–kuat), sedangkan ekstrak air 10–14 mm (kategori sedang). Molecular docking memperlihatkan luteolin memiliki energi ikatan −8,6 kcal/mol (PBP2a) dan −7,9 kcal/mol (DNA gyrase), sementara hyperoside −9,2 kcal/mol dan −8,4 kcal/mol. Kedua flavonoid tersebut lebih baik dibanding ligan kontrol cefotaxime (−7,1 kcal/mol), dengan interaksi hidrogen pada residu aktif penting (Ser392, Thr621, Asn450). Ekstrak daun bidara memiliki aktivitas antibakteri signifikan terhadap E. coli dan S. aureus. Senyawa hyperoside menunjukkan potensi terbesar sebagai kandidat antibakteri berdasarkan kombinasi data in vitro dan in silico.
Co-Authors Azizah, Norma Nur Azizah I Gusti Ayu Sri Mahendra Dewi MADE RATNA SARASWATI . Wimpie I Pangkahila