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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Locus Penelitian dan Pengabdian
Aditea Etnawati Putri
Universitas Airlangga
Aerospace Engineering Automotive Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Mathematics Medicine & Pharmacology Public Health

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Examining convalescent plasma transfusion in severe COVID-19 patients, recent research highlights the significance of S-RBD antibodies and IL-10 levels Etnawati Putri, Aditea; Agustina Tambunan, Betty; Pujo Semedi, Bambang; Mohd Yusoff , Narazah; Salmah Bt Noordin, Siti
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 3 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i3.50859

Abstract

Convalescent plasma (CP) may be an option for people with severe COVID-19. However, its efficiency remains unknown. A study was done to determine whether the levels of Anti-SARS-CoV-2 Spike Receptor-Binding Domain (S-RBD) antibodies and IL-10 in COVID-19 patients who had CP transfusion were related to their survival status. The observational cohort study included 40 patients with severe COVID-19 who were followed for 28 days after receiving a CP transfusion. Antibody and IL-10 levels were assessed on Day 1 before to CP transfusion and on Days 1, 2, and 7 following CP transfusion. Twenty six (65%) of the 40 patients survived. Anti-SARS-CoV-2 S-RBD antibody levels were observed to be significantly higher on Days 1, 2, and 7 following CP transfusion (p-value 0.05). Furthermore, IL-10 levels dropped significantly on Days 2 and 7 (p-value 0.05). However, neither the CT value nor the patients' survival status were linked to greater antibody levels or changes in IL-10 levels. According to the findings, CP transfusion can greatly enhance anti-SARS-CoV-2 S-RBD antibody levels while drastically decreasing IL-10 levels. These findings may have therapeutic implications for the use of CP as a COVID-19 therapy option. More research is needed to determine its efficacy in enhancing the survival rate of COVID-19 patients with severe symptoms.
Correlation of Ferritin Serum With Estimated Glomerular Filtration Rate in Adult Beta Thalassemia Major Patients Andriantono, Immanuel; Romadhon, Pradana Zaky; Suryantoro, Satriyo Dwi; Putri, Aditea Etnawati
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 6 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i6.4099

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Patients suffering from beta thalassemia major experienced iron overload due to hemolysis, increased iron absorption in the gastrointestinal tract, and primarily due to repeated blood transfusions. This iron accumulation was exacerbated by the lack of a physiological mechanism for the body to naturally eliminate excess iron. One of the main complications of this condition was iron toxicity, which could damage various organs, including causing renal dysfunction. The persistence of this condition was associated with an increased risk of kidney injury, which could potentially lead to acute kidney injury and renal complications. The objective of the present study was to ascertain the correlation between serum ferritin levels and eGFR in adult patients diagnosed with beta thalassemia major in order to achieve the third focus of Sustainable Development Goals (SGD’s) in good health and well-being. The present study was a quantitative research study that utilized an observational analytic design with a cross-sectional approach. It was based on secondary data from the medical records of adult patients with beta thalassemia major at the Department of Internal Medicine, Universitas Airlangga Hospital. Subjects were selected using consecutive sampling. The statistical analysis of the correlation between serum ferritin levels and eGFR was conducted using Spearman tests. A total of 62 adult patients with beta thalassemia major were include this study, with mean age of 26 years. The majority of participants (42 patients or 67,7%) had serum ferritin levels below 1000 ?g/L. All of Subjects (62 patients) had eGFR within the normal range, all were classified as G1 (> 90 mL/min/1.73 m²). The Spearman analysis results showed a weak positive correlation between serum ferritin levels and eGFR with a correlation coefficient (r = 0.277) and a p-value of 0.029. Conclusion: There is a weak positive correlation between serum ferritin levels and eGFR in adult patients with beta thalassemia major.
Co-Authors Andriantono, Immanuel Betty Agustina Tambunan Mohd Yusoff , Narazah Pujo Semedi, Bambang Romadhon, Pradana Zaky Salmah Bt Noordin, Siti Suryantoro, Satriyo Dwi