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All Journal Jurnal Kedokteran Syiah Kuala Indonesian Journal of Tropical and Infectious Disease MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Hearty : Jurnal Kesehatan Masyarakat Faletehan Health Journal Jurnal Respirasi (JR) Ina Kidney JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Locus Penelitian dan Pengabdian Jurnal Keperawatan
Suryantoro, Satriyo Dwi
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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ACUTE KIDNEY INJURY (AKI) PADA KEHAMILAN Satriyo Dwi Suryantoro; Djoko Santoso; Sarah Firdausa
Jurnal Kedokteran Syiah Kuala Vol 21, No 1 (2021): Volume 21 Nomor 1 April 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i1.19284

Abstract

Acute Kidney Injury (AKI) in pregnancy remains a cause for fetomaternal morbidity and mortality, particularly in developing countries. Hypertensive complications of pregnancy (preeclampsia/eclampsia, HELLP syndrome) remains the leading cause of AKI in pregnancy. A set of systemic and renal physiological adaptive mechanisms occur during a normal gestation that will cause several changes in laboratory parameters of renal function, electrolytes, fluid and acid – base balance. Diagnosis of AKI in pregnancy is based on the serum creatinine increase and reduction of urine output. Management of AKI in pregnancy requires a multidisciplinary approach between nephrologists and obstetricians for optimizing care for both mother and child. In approaching AKI in pregnant woman, emphasis should be placed on making early and accurate diagnosis to allow prompt intervention and to facilitate recovery from AKI.
Kidney-Pulmonary Crosstalk from Pathophysiological Perspective Sharifa Audi Salsabila; Alfian Nur Rosyid; Maulana Antiyan Empitu; Ika Nindya Kadariswantiningsih; Satriyo Dwi Suryantoro; Mutiara Rizki Haryati; Mochammad Thaha; Yusuke Suzuki
Jurnal Respirasi Vol. 8 No. 1 (2022): January 2022
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.477 KB) | DOI: 10.20473/jr.v8-I.1.2022.44-51

Abstract

Lungs and kidneys are distant organs which are functionally related in physiological and pathological contexts. Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are common complications in acute kidney injury (AKI) or acute-on-chronic kidney disease. On the other hand, there is a considerable risk of AKI in respiratory diseases such as ARDS and chronic obstructive pulmonary disease (COPD). From a pathophysiological point of view, the kidney-lung crosstalk involves interdependency in the regulation of fluid hemodynamic, acid-base and electrolyte balance, and carbon dioxide partial pressure. Aside from the closely related function, the crosstalk may also occur by non-classical mechanisms such as through activation of systemic inflammation, excessive cytokine release, and the formation of auto-antibody which targets both kidneys and lungs. This review discussed several disease mechanisms by which kidney and lungs affect each other or are simultaneously affected by pathological processes. Particularly, this review discussed some specific mechanisms in lungs and kidneys, such as how hypoxemia and hypercapnia induced by ARDS may reduce kidney function and how distance injury on kidney may affect the development of non-cardiogenic edema lungs.
The Role of Klotho G395A Gene Polymorphism in Atherosclerotic Cardiovascular Disease and Mortality Risk Scores in Non-dialysis Chronic Kidney Disease Hendri Susilo; Budi Susetyo Pikir; Mochammad Thaha; Mochamad Yusuf Alsagaff; Satriyo Dwi Suryantoro; Citrawati Dyah Kencono Wungu; David Setyo Budi; Laurentius Andre; Cennikon Pakpahan
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.1975

Abstract

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Klotho expression was reduced in patients with CKD, leading to vascular calcification, endothelial dysfunction, and atherosclerosis. We investigated the role of the klotho G395A gene polymorphism and plasma klotho level in the ten-year risk of atherosclerotic cardiovascular disease (ASCVD) and CVD mortality in CKD patients.METHODS: We used the PCR-CTPP assay method to genotype klotho G395A single nucleotide polymorphism (SNP) in 72 non-dialysis CKD patients. The klotho level was determined using the enzyme-linked immunoassay (ELISA) method. Path analysis was used to determine the relationship between the klotho G395A SNP, plasma klotho level, ASCVD risk score, and CVD mortality risk score.RESULTS: Our results showed that the GA genotype had lower plasma klotho levels than the GG genotype (path coefficient=-0.185, p=0.000). There was a significant negative correlation between plasma klotho level and the ASCVD risk score (r=-0.243, p=0.040), but no significant correlation was found between plasma klotho level and the CVD mortality risk score (r=-0.145, p=0.225). Path analysis showed that plasma klotho level had a significant negative direct effect on ASCVD risk score (path coefficient=-0.272, p=0.000) and an indirect effect on CVD mortality risk score (path coefficient=0.187, p=0.005).CONCLUSION: Klotho G395A SNP might reduce lower plasma klotho levels, which increased ASCVD and CVD mortality risk scores in non-dialysis CKD patients. However, other risk factors such as age, CKD stages, hypertension, and smoking should be taken into consideration. Therefore, large-scale genetic association studies with adjusted variables could be conducted in various ethnic groups for a more robust result.KEYWORDS: klotho, single nucleotide polymorphism, cardiovascular disease, chronic kidney disease
Kombinasi Terapi Cermin dan Menggenggam Bola Karet terhadap Kekuatan Otot Ekstremitas atas pada Pasien Pasca Stroke: Tinjauan Sistematik Ni Putu Diah Ayu Rusmeni; Yulis Setiya Dewi; Satriyo Dwi Suryantoro
Jurnal Keperawatan Vol 14 No 3 (2022): Jurnal Keperawatan: Supp September 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.664 KB)

Abstract

Stroke yang juga dikenal sebagai penyakit serebrovaskular merupakan penyakit dengan manifestasi klinis yaitu hemiparesis sehingga penderita tidak mampu melakukan aktivitas atau mobilisasi. Upaya yang dapat dilakukan adalah dengan memberikan kombinasi terapi cermin dan mencengkeram bola karet. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh terapi kombinasi cermin memegang bola karet terhadap kekuatan otot ekstremitas atas pada pasien pasca stroke berdasarkan penelitian selama 10 tahun terakhir. kata kunci “Terapi Cermin DAN Mencengkeram Bola Karet DAN Kekuatan Otot DAN Pasca Stroke”. Hasil yang diperoleh adalah 872 artikel dari 4 database: Scopus, Web of Science, Science Direct, dan Pro Quest. Artikel yang memenuhi syarat berdasarkan penilaian risiko bias menggunakan penilaian kritis JBI untuk uji coba kontrol acak dan daftar periksa eksperimental diperoleh dari 15 artikel. Fungsi ekstremitas atas pada sisi hemiparetik setelah intervensi meningkat secara signifikan setelah intervensi terapi cermin dan karet terapi mencengkeram bola. Terapi cermin yang dikombinasikan dengan latihan mencengkeram bola karet dilakukan selama 2 minggu dengan dosis 1 kali sehari pada pagi hari, dengan durasi 5-7 menit. Terapi cermin merupakan terapi yang dapat meningkatkan kekuatan otot yang mengalami hemipaeresis melalui umpan balik visual, serta grip bola karet yang dapat merangsang serat otot untuk berkontraksi sehingga dapat meningkatkan kekuatan otot pada pasien pasca stroke yang murah, sederhana dan dapat dilakukan di rumah.
Hubungan Pengetahuan Hepatitis B dan Perilaku Berisiko Tinggi dengan Kejadian Hepatitis B pada Remaja Satriyo Dwi Suryantoro; Pradana Zaky Romadhon; Faizal Kurniawan; Makhfudli Makhfudli; Nala Astari Pramesti; Vetty Silvana Maulida
Faletehan Health Journal Vol 10 No 01 (2023): Faletehan Health Journal, Maret 2023
Publisher : Universitas Faletehan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33746/fhj.v10i01.518

Abstract

Hepatitis B is a disease caused by Hepatitis B virus (HBV) and the most common type of Hepatitis in Indonesia at 21.8%. High-risk behaviors such as unsafe sexual intercourse and indiscriminate use of syringes can cause Hepatitis B. This study aimed to analyze the relationship between knowledge of Hepatitis B and high-risk behaviors with the incidents of Hepatitis B among adolescents. The study was conducted by using a cross-sectional design and 50 adolescents as the respondents. The data collection was carried out by using a questionnaire. Correlation analysis was performed by Fisher’s exact test. 62% of adolescents had a low level of knowledge about Hepatitis B, 54% of adolescents never engaged in high-risk behavior, and 70% of adolescents claimed that they were never exposed to Hepatitis B. This study did not show any relationship between knowledge of Hepatitis B and the incidents of Hepatitis B (p 0.086 > α 0.05) and there was a relationship between high-risk behaviors in adolescents and the incidents of Hepatitis B (p 0.002 < α 0.05). Adolescents' knowledge of Hepatitis B and high-risk behaviors in adolescents are important factors that need to be controlled to decrease Hepatitis B rates. Socialization of Hepatitis B knowledge is needed to understand the virus, causes, transmission channel, how to stop the spread, and treatments should be taken when being infected by Hepatitis B virus.
Providing Intradialytic Parenteral Nutrition Therapy Does Not Improve Anthropometric Status in Hemodialysis Patients with Malnutrition Suryantoro, Satriyo Dwi; Tjempakasari, Artaria; Nurwidda, Arvi Dian Prasetia; Widodo, Widodo; Thaha, Mochammad; Mardiana, Nunuk
Indonesian Journal of Kidney and Hypertension Vol 1 No 1 (2024): Volume 1 No. 1, April 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i1.123

Abstract

Background: Malnutrition is prevalent in hemodialysis patients and significantly impacts prognosis. It can result from reduced food intake and protein loss during hemodialysis. Nutritional status is determined through anthropometric examinations, which include upper arm circumference (UAC), body mass index (BMI), hand grip strength, bicep, and tricep fold thickness. Laboratory examinations like total cholesterol and Malnutrition Inflammation Score (MIS) or Subjective Global Assessment (SGA) are also used. Intradialytic Parenteral Nutrition (IDPN) is expected to maintain or improve the nutritional status of hemodialysis patients. Objective: This research examines the impact of parenteral nutrition therapy on the anthropometric status of malnourished hemodialysis patients. Methods: This cross-sectional study, a sub-analysis of a larger nutritional therapy study, involved 24 hemodialysis patients experiencing malnutrition based on SGA B and C criteria with 1-10 years of hemodialysis. IDPN therapy was provided, and anthropometric measurements and total cholesterol were taken at baseline and three months after nutritional therapy. Data processing used comparative statistical analysis. Results: The mean age was 45.33 years, with 14 males and 10 females. After 3 months, there were no significant differences in UAC (mean difference = 0.13; p = 0.69), BMI (mean difference = 0.13; p = 0.50), hand grip strength (mean difference = -0.96; p = 0.282), biceps skinfold thickness (mean difference = 0.13; p = 0.69) and triceps (mean difference = 0.59; p = 0.134) or total cholesterol (mean difference = -1.5; p = 0.71). Conclusion: IDPN therapy for 3 months did not improve the anthropometric status of hemodialysis patients with malnutrition.
Manifestations of Acute Pancreatitis in Severe COVID-19 Patients: Is This a Coincidence? Romadhon, Pradana Zaky; Suryantoro, Satriyo Dwi; Windradi, Choirina; Mahdi, Bagus Aulia; Agustin, Esthiningrum Dewi; W, Krisnina Nurul; Novendrianto, Dwiki
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 2 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i2.26472

Abstract

Coronavirus Disease-19 (COVID-19) adalah penyakit yang disebabkan oleh Severe Acute Acute Respiratory Coronavirus-2 (SARS-CoV2) yang berasal dari China, menyebar dengan cepat ke seluruh bagian negara lain yang menyebabkan pandemi dunia. Dengan derajat gejala yang bervariasi yang disebabkan oleh COVID-19, virus ini menyebabkan kerusakan pada beberapa organ, baik karena efek infl amasi tidak langsung maupun efek sitopatik. Data terkait keterlibatan pankreas dalam kasus COVID-19 masih belum jelas. Seorang laki-laki usia 83 tahun dirawat karena gejala COVID-19 berat. Dalam perawatan, pasien memberikan gejala dan tanda pankreatitis akut tanpa diketahui faktor resiko yang terkait. Pada pemeriksaan didapatkan RT-PCR SARS-CoV2 positif dari swab nasofaring, amilase lipase yang meningkat serta gambaran ultrasound khas untuk pankreatitis akut. Tatalaksana pasien tetap berdasar pada kasus SARS-CoV2 dengan isolasi, oksigenasi, pemberian anti virus dan suportif. Pemberian antibiotik juga didasarkan pada terapi empiris yang kemudian disesuaikan hasil sensitifi tas kultur. Skor prognosis pankreatitis menunjukkan risiko kematian pada kasus moderate. Pada perjalanan, pasien meninggal karena shock sepsis. Prevalensi pankreatitis akut dan tingkat keparahannya perlu diamati. Dalam artikel ini, kami menyajikan kasus pankreatitis akut yang terjadi pada COVID-19 parah dengan faktor risiko yang tidak diketahui.Diagnosis penyebab kasus pankreatitis masih belum jelas tetapi beberapa bukti autopsi kasus infeksi SARS-CoV2 dengan pankreatitis menyebutkan bahwa infeksi virus ini dapat menyebabkan injuri pada pankreas.. Kondisi sepsis dapat diakibatkan infeksi virus SARS-CoV2 (viral sepsis) atau ko-infeksi bakteri. Oleh karena itu, rasionalisasi penggunaan antibiotik juga diperlukan. Kasus ini merupakan kasus yang membutuhkan managemen holisitik dan intensif karena kedua kondisi berpotensi dapat memperberat satu sama lain. Pengenalan awal kegawatan serta terapi tepat merupakan hal yang penting dapat menunjang kesintasan pasien.
Convalescent Plasma Therapy: The Early Use in Moderate to Severe COVID-19 Patients in Hospitals with Limited Resources Mahdi, Bagus Aulia; Suryantoro, Satriyo Dwi; Romadhon, Pradana Zaky; Windradi, Choirina; Widiyastuti, Krisnina Nurul; Novendrianto, Dwiki; Widiasi, Etha Dini; Agustin, Esthiningrum Dewi; Firdausa, Sarah; Alkaff, Firas Farisi
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 3 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i3.29113

Abstract

COVID-19 cases in Indonesia in the period of June-July 2021 showed a catastrophic spike. During this period, a recently discovered variant, the delta variant, appeared to be one of the sources of COVID-19 infection. Treatment modalities are limited due to reduced stock of drugs. A case of a 63-year-old man has been reported, with a history of having been vaccinated with two doses of Sinovac, experiencing moderate-to-severe symptoms of COVID-19 infection then given convalescent plasma therapy since his initial admission to the hospital. Three days after being given convalescent plasma therapy, the improvement was noticeable. Shortness of breath, cough, fever, and weakness were less complained. On the seventh day the patient fully recovered and got discharged. Convalescent plasma therapy was e ective in early stage and was able to improve outcomes. Indonesia needs sucient stocks of convalescent plasma as a therapy to overcome the limitations of medicines.
Type 2 Diabetes Mellitus Status with Ankle-Brachial Index among Patients with Diabetic Foot Ulcer at Universitas Airlangga Hospital, Surabaya Anisah, Hana; Limanto, Danang Himawan; Suryantoro, Satriyo Dwi; Utomo, Budi; Permana, Putu Bagus Dharma
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 1 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I12024.51-56

Abstract

Highlights: ABI was not influenced by diabetic status due to potential confounders. A more severe form of diabetic ulcer was associated with a lower ABI value.   Abstract Introduction: Diabetic foot ulcer (DFU) is one of the most significant complications of uncontrolled type 2 diabetes mellitus (T2DM) that may affect a patient's prognosis and quality of life. This study aimed to identify the association between diabetic status, DFU severity, and other clinical factors with ankle-brachial index (ABI) score and category. Methods: This was a cross-sectional study under a consecutive sampling frame conducted from 1 November 2022 to 31 January 2023 at Universitas Airlangga Hospital, Surabaya. Primary data for ABl were measured from T2DM patients with DFU in the Thoracic and Cardiovascular Polyclinic. Meanwhile, secondary clinical data were collected from the Department of Internal Medicine based on the inclusion and exclusion criteria specified in the patient's medical records. The International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26 was utilized for the statistical analysis. Results: Out of 30 included patients, 63.33% had uncontrolled diabetic status, and the average ABI score was 0.999 ± 0.19. DFU severity was significantly associated with the ABI score and ABI category. Patients indicated with angioplasty exhibited a markedly lower ABI score than those without (mean 0.32 vs 1.01; p < 0.001). Indication of angioplasty was the only clinical factor significantly associated with a lower ABI score (p < 0.001). Conclusion: The status of T2DM was unrelated to ABI. Future research is recommended to advance the understanding of peripheral artery disease in diabetic foot ulcer patients.
Analysis of the Relationship between Education, Merital Status, Age of Marriage and Exposure to Education with Awareness of Thalassemia Screening in Indonesia Zaky, Pradana; Suryantoro, Satriyo Dwi; Kurniawan, Faizal; Maulida, Vetty Silvana
Faletehan Health Journal Vol 12 No 01 (2025): Faletehan Health Journal, Maret 2025
Publisher : Universitas Faletehan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33746/fhj.v12i01.777

Abstract

Indonesia sebagai negara dengan jumlah kasus thalasemia yang cukup banyak masih kurang secara pengetahuan dan kesadaran akan penyakit ini. Kurangnya pengetahuan ini ditinjau sebabnya dan dapat berdampak pada jumlah kasus screening yang rendah. Tujuan penelitian ini adalah untuk menganalisis hubungan usia pernikahan, status pernikahan, tingkat pendidikan, dan keterpaparan edukasi terhadap pemahaman masyarakat mengenai kesadaran screening thalasemia. Penelitian ini merupakan studi cross-sectional dengan jumlah sampel 35 responden yang diambil dengan kombinasi metode convenience sampling dan purposive sampling. Analisis data menggunakan uji chi square. Hasil studi menunjukkan bahwa keterpaparan edukasi thalasemia (p value 0,018) secara statistik memiliki hubungan yang signifikan dengan kesadaran melakukan screening thalasemia. Sementara itu, variabel status pernikahan (p value 0,160), tingkat pendidikan (p value 0,502), dan usia pernikahan (p value 0,128) tidak memiliki hubungan dengan kesadaran melakukan screening thalasemia. Pengetahuan thalasemia perlu ditingkatkan dengan cara mempromosikan strategi pencegahan thalasemia melalui edukasi, deteksi dini, dan konseling pranikah.
Co-Authors Aditea Etnawati Putri Agustin, Esthiningrum Dewi Alkaff, Firas Farisi Andriantono, Immanuel Ardhi, Mohammad Saiful Artaria Tjempakasari, Artaria Budi Susetyo Pikir Budi Utomo Danang Himawan Limanto David Setyo Budi Divastuti, Kedyatasya Rae Fahirah Djoko Santoso Etha Dini Widiasi Faizal Kurniawan Faizal Kurniawan Firdausa, Sarah FIRDAUSA, SARAH Hana Anisah, Hana Hendri Susilo Ika Nindya Kadariswantiningsih Kurniawan, Faizal Kurniawan Laurentius Andre Mahdi, Bagus Aulia Makhfudli Makhfudli Maulana Antiyan Empitu Maulida, Vetty Silvana Mochamad Yusuf Alsagaff MOCHAMMAD THAHA Mutiara Rizki Haryati Nala Astari Pramesti Ni Putu Diah Ayu Rusmeni Novendrianto, Dwiki Nunuk Mardiana, Nunuk Nurwidda, Arvi Dian Prasetia Pakpahan, Cennikon Permana, Putu Bagus Dharma Pramesti, Nala Astari Romadhon, Pradana Zaky Rosyid, Alfian Nur Sharifa Audi Salsabila Sita Setyowatie Vetty Silvana Maulida W, Krisnina Nurul Widiyastuti, Krisnina Nurul Widodo Widodo Windradi, Choirina Wungu, Citrawati Dyah Kencono Yulis Setiya Dewi Yusuke Suzuki Zaky, Pradana