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All Journal KOVALEN: Jurnal Riset Kimia Chimica et Natura Acta
Seviani, Winda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology

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Synthesis of 1,2-Di(phenyl)ethan-1,2-dione through Oxidation of 2-Hydroxy-1,2-Dipheniletanone by using Copper(II) Citrate Seviani, Winda; Fadlan, Arif; Wirastuti, Vania
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.50263

Abstract

1,2-Di(phenyl)-1,2-dione widely used in chemical and pharmaceutical industries and found as a framework in secondary metabolites can be obtained through oxidation of 2-hydroxy-1,2-diphenylethanone using strong acids, homogeneous, heterogeneous, and metal catalysts. However, these oxidation methods exhibit various drawbacks. This study reported the oxidation of 2-hydroxy-1,2-diphenylethanone by using copper(II) citrate to produce 1,2-di(phenyl)-1,2-dione. The oxidation performed with copper(II) citrate and ammonium nitrate in glacial acetic acid as solvent yielded 1,2-di(phenyl)-1,2-dione in 88% yield higher than the nitric acid method (79% yield). The FTIR, NMR spectriscopies, and mass analysis confirmed the structure of 1,2-di(phenyl)ethane-1,2-dione. The oxidation of 2-hydroxy-1,2-diphenylethanone using copper(II) citrate is proposed by the formation of Cu⁺ ions and a resonance-stabilized 2-hydroxy-1,2-diphenylethanone radical resulting in 1,2-di(phenyl)ethane-1,2-dione.
Evaluation of Antioxidant Activity of Branch Extract from Pouteria campechiana (Sawo Walanda) Batari, Nirmala Puteri; Setyo Purnomo, Adi; Seviani, Winda
KOVALEN: Jurnal Riset Kimia Vol. 11 No. 1 (2025): August Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2025.v11.i1.17792

Abstract

The objective of this research was to assess the antioxidant activity of branch extract (Pouteria campechiana) through analysis of bioactive compound content and antioxidant activity. The sample was extracted through maceration, utilizing methanol as the solvent which produced a yield of 6.03 %. The quantity of phenolic constituents in the extract was determined using the Folin-Ciocalteu method, with gallic acid as the standard, yielding a result of 195.22 mg GAE/g extract. The quantity of flavonoid constituents was determined using gallic acid as a standard resulting in a value of 830.5 mg QE/g extract. Antioxidant activity was tested using two methods, namely DPPH and ABTS. The results of the DPPH test showed an inhibition percentage of 91% with an IC50 value of 3,322 ppm, while the ABTS test showed an inhibition of 99% with an IC50 of 2,206 ppm at a concentration of 10,000 ppm. Based on these results, the Pouteria campechiana branch extract has very weak antioxidant activity, suggests a limited potential as natural bioactive compound source.
Co-Authors Batari, Nirmala Puteri Fadlan, Arif Setyo Purnomo, Adi Wirastuti, Vania