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All Journal Jurnal Cakrawala Pendidikan dan Biologi (jucapenbi)
Nayla Fazilla Nadin
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Identifikasi Efektivitas Daun Pedada (Sonneratia Caseolaris) Sebagai Antimikroba dan Potensinya dalam Pengobatan Tradisional Nayla Fazilla Nadin; Ardi Mustakim
Jurnal Cakrawala Pendidikan dan Biologi Vol. 2 No. 3 (2025): September: Jurnal Cakrawala Pendidikan dan Biologi
Publisher : Asosiasi Riset Ilmu Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jucapenbi.v2i3.614

Abstract

Pedada leaves (Sonneratia caseolaris), a type of mangrove plant that grows in tropical and subtropical coastal areas, have high ecological and pharmacological value. In addition to functioning as coastal protection from abrasion and seawater intrusion, this plant is also known to contain various secondary metabolite compounds such as flavonoids, tannins, saponins, and alkaloids. These compounds have been widely reported to have important biological activities, one of which is as an antimicrobial agent. This study aims to identify the effectiveness of pedada leaf ethanol extract in inhibiting the growth of pathogenic microorganisms, especially bacteria that cause infections. The extraction process was carried out using 96% ethanol solvent through the maceration method, namely soaking the material in the solvent for a certain time to optimally obtain active compounds. The obtained extract was then tested for its antimicrobial activity using the disc diffusion method against test bacteria, both Gram-positive and Gram-negative. The inhibition zone formed around the disc was measured as an indicator of the antibacterial effectiveness of the extract. The results showed that pedada leaf extract was able to produce inhibition zones with varying diameters depending on the concentration used. The higher the extract concentration, the larger the diameter of the inhibition zone formed. This indicates a positive relationship between extract concentration and its antibacterial strength. This activity is believed to originate from the ability of compounds such as flavonoids and tannins to damage bacterial cell walls or disrupt microbial metabolic processes. This study provides initial evidence that pedada leaves have potential as an environmentally friendly and sustainable source of natural antibacterials. This potential is highly relevant in efforts to develop alternative antibacterial materials based on local plants, especially amidst increasing bacterial resistance to synthetic antibiotics.
Penelitian Terapi Berbasis Sel Perkembangan Baru dalam Immunoterapi dan Gen Theraphy Nayla Fazilla Nadin; Ardi Mustakim
Jurnal Cakrawala Pendidikan dan Biologi Vol. 2 No. 1 (2025): Maret: Jurnal Cakrawala Pendidikan dan Biologi
Publisher : Asosiasi Riset Ilmu Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jucapenbi.v2i1.152

Abstract

Research into cell-based therapies has grown rapidly in recent years, particularly in the context of immunotherapy and gene therapy. Cell-based therapy is an innovative approach that uses living cells, such as genetically modified T cells, to recognize and destroy cancer cells or other diseases. Additionally, developments in gene therapy allow scientists to edit or repair damaged genes, thereby restoring normal cell function. This research aims to explore recent developments in cell-based therapies, as well as their impact on immunotherapy and gene therapy. The main focus is on methods used to modify cells, such as CRISPR/Cas9 technology, as well as techniques to improve the ability of immune cells to target and kill cancer cells. The research also covers the challenges faced in this therapy, including the risk of side effects, genetic stability, and sustainability of transplanted cells. The research results show that cell-based therapies offer new hope in the treatment of difficult-to-treat diseases, such as cancer and rare genetic disorders. However, further research is still needed to ensure its long-term safety and effectiveness. This research is expected to provide in-depth insight into the potential and challenges of cell-based therapies, as well as providing a basis for future clinical development.
Co-Authors Ardi Mustakim