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Arifah, Naila Zanubah
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Humanities Computer Science & IT Economics, Econometrics & Finance Education Social Sciences

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Anti-Elastase Potential in Vitro of Koro Komak (Lablab Purpureus) Extract as Anti-Aging Protection Arifah, Naila Zanubah; Helianti, Dina; Efendi, Erfan
Journal of Social Research Vol. 4 No. 8 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i7.2698

Abstract

The aging process leads to skin changes such as wrinkles and loss of elasticity, often accelerated by premature aging caused by factors like UV radiation and reactive oxygen species (ROS). Elastase, an enzyme responsible for degrading elastin in the skin’s extracellular matrix, plays a critical role in this process. This study aimed to investigate the anti-elastase potential of koro komak (Lablab purpureus) extract, a plant rich in polyphenolic compounds, through in vitro testing. A quasi-experimental design was employed, using different concentrations of the extract compared to ascorbic acid as a positive control. Phytochemical screening confirmed the presence of flavonoids, phenols, and tannins. The extract exhibited moderate anti-elastase activity with an IC?? value of 128 ?g/mL, and at 200 ?g/mL concentration, it inhibited elastase enzyme activity by 65.90%. These findings suggest that koro komak extract has promising potential as a natural anti-aging agent by protecting skin elasticity through elastase inhibition.
Co-Authors Dina Helianti Erfan Efendi