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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) IJOEP : International Journal of Ecophysiology
Rumahorbo, Cheryl Grace Pratiwi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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The Effect Of Nacl Content Reduces Diarrhea Problems As Well As The Efficacy Of Citrus Aurantifolia In It Silaen, Srinatalia; Rumahorbo, Cheryl Grace Pratiwi
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11246

Abstract

Lime peel contains saponins, flavonoids, alkaloids, tannins, and essential oils that have antibacterial activity. This study aims to explain the relationship between the use of lime peel as a traditional medicine and its bioactivity. Antibacterial activity testing used a Completely Randomized Design (CRD) spray method. The concentrations of lime peel extract used were 12.5, 25, 37.5, and 50%. The positive control used ciprofloxacin and the negative control was 10% DMSO. The results obtained were analyzed by Quasi-Experimental test. The use of plants as traditional medicine is related to their bioactivity and secondary metabolite content. Various researchers have successfully proven the bioactivity of lime peel, namely anticholesterol, antimicrobial, antioxidant, antihypertensive, antiosteoporosis, and anticancer. The concentration and length of contact time are directly proportional to the inhibitory power of CA water against Staphylococcus aureus bacteria. The bioactivity of CA extract as an antimicrobial is influenced by various factors, including the type of microbe, concentration, and contact time. This new study shows that lime peel has the benefit of killing harmful bacteria, such as Escherichia coli, which causes diarrhea. The vitamin C and antioxidants in lime peel are believed to be able to ward off these bacteria.
Histological Analysis of Langerhans Islets and β-Cell Morphology in Diabetic Rats Treated with Bischofia javanica Nanoherbal Silaen, Srinatalia; Silaban, Irving; Sitepu, Christina Sitepu; Rumahorbo, Cheryl Grace Pratiwi
International Journal of Ecophysiology Vol. 7 No. 2 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i2.22691

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder marked by hyperglycemia and β-cell damage. Standard therapies like metformin reduce blood glucose but rarely restore pancreatic structure. Bischofia javanica leaves, rich in flavonoids and phenolics, have traditional antidiabetic use with antioxidant and anti-inflammatory potential. This study evaluated the effects of nanoherbal B. javanica on pancreatic histopathology in streptozotocin (STZ)-induced diabetic rats. Thirty male Wistar rats were divided into six groups: negative control (KN), positive control (KP), metformin 150 mg/kg BW (KS), and nanoherbal B. javanica at 50 mg/kg BW (P1), 100 mg/kg BW (P2), and 200 mg/kg BW (P3). Pancreatic tissues were examined using hematoxylin-eosin staining and analyzed with the Pancreatic Injury Severity Score (ISS). Results showed that KP developed severe damage with the highest ISS (2.86), characterized by islet shrinkage, β-cell degeneration, insulitis, fibrosis, and vascular abnormalities. KS showed moderate improvement (ISS 1.71), while nanoherbal treatment groups exhibited dose-dependent recovery. P3 (200 mg/kg BW) achieved near-normal morphology with the lowest ISS (0.71), demonstrating superior effects compared to KS. These findings suggest that nanoherbal B. javanica protects and regenerates pancreatic β-cells through antioxidant and anti-inflammatory mechanisms, while nanoformulation enhances bioavailability and therapeutic efficacy of its active compounds.
Co-Authors Silaban, Irving Silaen, Srinatalia Sitepu, Christina Sitepu