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All Journal Nusantara Hasana Journal Indonesian Journal of Pharmacology and Therapy Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Intan Adevia Rosnarita
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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EFEKTIVITAS EDUKASI BEYOND USE DATE SALEP KULIT DAN MATA TERHADAP TINGKAT PENGETAHUAN MASYARAKAT DESA PECANGAAN KULON Apriliasari, Fiona; Eko Retnowati; Intan Adevia Rosnarita
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1528

Abstract

Beyond Use Date (BUD) is the time limit for using a medication after the packaging is opened or after compounding is completed. Public understanding of BUD, especially for topical skin and eye ointments, remains low. This condition may decrease the effectiveness of treatment and increase the risk of side effects. The aim of this study was to compare the effectiveness of educational media leaflets and videos in improving public knowledge about BUD. This study used a quasi-experimental design with a pretest-posttest approach, involving three groups: leaflet, video, and control. A total of 366 respondents were selected using purposive sampling. The educational intervention was conducted over seven days, and knowledge was measured using a questionnaire that had been tested for validity and reliability. Data were analyzed using the Wilcoxon Signed Rank Test to assess changes in knowledge before and after the intervention, and the Mann-Whitney U Test to compare the effectiveness between media. The results show a significant increase in knowledge after the intervention, particularly in the leaflet group (61.50) and video group (60.50), while the control group shows a decrease (57.85). The Mann-Whitney U Test indicates that leaflets are more effective than videos (p = 0.000), with the highest mean rank found in the leaflet group (138.41). It can be concluded that education using leaflet media is more effective in increasing public knowledge about BUD, as it is easier to understand, can be read repeatedly, and allows direct interaction during health education sessions.
FORMULASI MASKER GEL LIDAH BUAYA (Aloe Vera) UNTUK PENGENDALIAN BAKTERI Propionibacterium acnes Irvan Shahrul Hidayat; Muhammad Nurul Fadel; Intan Adevia Rosnarita
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1662

Abstract

Acne (Acne vulgaris) is a common skin problem, especially among adolescents, with a prevalence reaching 80-85% in Indonesia. One of the main causes of acne is the bacteria Propionibacterium acnes. Acne treatment usually uses synthetic antibiotics, but long-term use can cause side effects and bacterial resistance. Alternative natural treatments are needed to address this problem. Aloe vera is known to have antibacterial, anti-inflammatory, and cell regeneration-accelerating properties, making it potentially useful in skin care products. The active ingredients of aloe vera, such as anthraquinones, saponins, and flavonoids, are effective in inhibiting the growth of Propionibacterium acnes. Peel-off gel masks were chosen as topical preparations because they are practical, have a cooling effect, and can increase the penetration of active ingredients. This study aims to develop a gel mask formulation with aloe vera extract and test its effectiveness in inhibiting the growth of Propionibacterium acnes bacteria. This study used a laboratory experimental method with a post-test only control group design. The formulas used included various concentrations of aloe vera extract (5%, 10%, and 15%) and a positive control using 1% clindamycin. Evaluation of the preparations included organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and antibacterial activity testing using the disc diffusion method. Antibacterial effectiveness testing was divided into 5 treatment groups. The inhibition zone test against Propionibacterium acnes was conducted to assess the effectiveness of each formulation. The test data were analyzed using the One Way ANOVA statistical method with SPSS 25 software to determine significant differences between groups. Antibacterial testing was conducted by disc diffusion. The results of the study on the aloe vera extract peel-off gel mask formulation showed good organoleptic physical quality, homogeneity, adhesiveness, and drying time of the preparation, while the viscosity and spreadability tests did not meet the requirements, and the pH test on formula F3 did not meet the pH requirements for mouthwash preparations. In the antibacterial activity test of the peel-off gel mask preparation, the inhibition zone values ​​were obtained at F0 2.23 mm; F1 4.8 mm; F2 6 mm; F3 7.2 mm; and the positive control 33.5 mm.
Efektivitas Penggunaan Ringer Laktat Vs Ringer Asetat terhadap Durasi Rawat Inap Pasien Demam Berdarah Dengue Erwin Ari Pratiwi; Eko Retnowati; Intan Adevia Rosnarita
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7462

Abstract

Dengue hemorrhagic fever (DHF) is an endemic disease with high prevalence in Indonesia, particularly during the rainy season, when incidence rates significantly increase. One of the main treatments is supportive therapy through intravenous fluid administration to prevent shock and aid recovery. Ringer’s lactate and Ringer’s acetate are commonly used crystalloid fluids that differ in electrolyte composition and metabolic pathways in the body. This study aimed to compare the effectiveness of Ringer’s lactate and Ringer’s acetate in relation to the length of hospital stay among DHF patients. This research employed a retrospective analytic observational design, using data from medical records of 154 inpatients at RSUD dr. R. Soetrasno Rembang in 2024. Data analysis included normality testing and independent t-tests. The average length of hospitalization in the Ringer’s lactate group was 4.35 ± 1.121 days, while in the Ringer’s acetate group it was 4.06 ± 1.185 days. Although there was a difference in mean values, statistical analysis showed no significant difference between the two groups (p = 0.131). No significant differences were also found in laboratory parameters (platelets, leukocytes, hemoglobin, hematocrit) or body temperature. Based on these findings, it can be concluded that both types of fluids are equally effective as supportive therapy for DHF patients. Fluid selection may be adjusted according to the patient’s clinical condition, availability, and cost considerations.
Asthma in pregnant woman and its management : a review Farni Yuliana Pratiwi; Hadiatussalamah; Intan Adevia Rosnarita; Yuda Anzas Mara; Novia Ariani Dewi
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.3239

Abstract

Asthma is the most common comorbidity in pregnant women and gives 30% of exacerbation experience. The other 30% will see improvement of their symptoms, and the rest will not see the changes. Exacerbations have become a major clinical concern in pregnant women. Medical concerns for the mother and the childbirth included low birth weight, preeclampsia, and preterm delivery. The major goal is to keep asthma under control to ensure mother's health and well-being, as well as fetal growth. Controlling asthma and preventing exacerbations are the main goals of asthma treatment during pregnancy. Treatment for asthma should ideally begin before conception. This is to avoid day-time and night-time symptoms, as well as to keep lung function. Furthermore, fetal oxygenation is a crucial factor during the pregnancy. With a few exceptions, asthma drugs are basically the same in pregnancy as they are in non-pregnant people. Inhaled corticosteroids (ICS) are often used as a controlling treatment. Budesonide is the recommended ICS. Short-acting β-agonist (SABA) preferable as reliever in acute asthma and to relieve exacerbation. As an add-on therapy for medium to high dose ICS, long-acting β-gonists (LABA) is often used. Virus infections and ICS nonadherence are the two most common causes of asthma exacerbations during pregnancy.
Co-Authors Apriliasari, Fiona Eko Retnowati Erwin Ari Pratiwi Farni Yuliana Pratiwi Hadiatussalamah Irvan Shahrul Hidayat Muhammad Nurul Fadel Novia Ariani Dewi Yuda Anzas Mara