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All Journal JITEK (Jurnal Ilmiah Teknosains) Journal of Stem Cell Research and Tissue Engineering
Fadila, Aghniya Nur Rizka
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Engineering Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Veterinary

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MESENCHYMAL STEM CELLS FROM ADIPOSE TISSUE TO TIGHTEN FACIAL SKIN Najah, Adilla Syahsiyatun; Fadila, Aghniya Nur Rizka; Wibawa, Alifah Mustari Mukti; Sulasikin, Almaydha Naim; Salsabila, Aulia Putri; Salsabila, Anbar Rania; Luthfi, Cahya Arsya; Raflianti, Desti; Hakim, Elsya Bayduri; Haryanto
Journal of Stem Cell Research and Tissue Engineering Vol. 9 No. 1 (2025): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v9i1.67461

Abstract

Skin elasticity is an important aspects of facial care. This study aims to explore the potential of mesenchymal stem cells (MSCs) derived from adipose tissue (adipose-derived stem cells) in facial skin tightening and assess their advantages and limitations in clinical applications. The methods used include literature searches from various officially published online sources as well as analysis of research data regarding the process of isolation, culture, differentiation and clinical applications of ADSCs. The main findings show that adipose-derived stem cells (ADSCs) are able to form new collagen, increase skin elasticity, and repair tissue damage due to aging. The culture process involving isolation of cells from adipose tissue and differentiation of the cells into fibroblasts is essential to exploit the regenerative potential of these cells. Although this technology is promising, this study also identified technical and regulatory challenges that need to be overcome, including patient health criteria, safe ADSc harvest procedures, isolation and culture processes that have a high chance of differentiation and post-application care of ADSc therapy. The significance of these findings is that a better understanding of the mechanism of action of ADSCs can make a positive contribution to the development of beauty therapies that are more effective and safer compared to conventional methods that are often unsatisfactory. Additionally, this approach is expected to provide a long-term solution for individuals who wish to maintain a youthful appearance without the risk of significant side effects. Thus, this research can be a step in integrating stem cell technology in the beauty industry, especially for anti-aging treatments.
APLIKASI BIOSENSOR UNTUK MENDETEKSI KONSENTRASI ALKOHOL DALAM DARAH Fadila, Aghniya Nur Rizka; Lathifah, Hasna Labib
(JITEK)Jurnal Ilmiah Teknosains Vol 11, No 2/Nov (2025): Jitek
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/jitek.v11i2/Nov.24062

Abstract

Konsumsi alkohol terus meningkat dengan laju peningkatan yang konsinten setiap 15 tahun sekali yaitu mencapai 106,7%, dengan jenis minuman keras, bir, wine dan lain-lain. Data lain menyebutkan setiap tahunnya alkohol bertanggung jawab atas sekitar 2,3 juta kematian dini di seluruh dunia. Tujuan dari kajian pustaka ini adalah untuk mengkaji pengembangan biosensor untuk deteksi alkohol dengan senssitivitas yang tinggi, murah dan produksinya yang mudah dan ramah lingkungan. Metode kajian ini berdasarkan studi literatur dengan menggunakan jurnal international yang terspesifikasi PubMed, ScienceDirect, Frontiers, dan MDPI. Hasil didapatkan bahwa biosensor yang dapat mendeteksi alkohol dalam spesimen darah, saliva dan keringat meliputi Sparfloxacin-Capped Gold Nanoparicle, Enzim amperometrik dengan alkohol dehydrogenase (AOX), alkohol dehydrogenase (ADH), wearable electrochemical alcohol biosensor, dan breathalyzer. Biosensor berbasis Sparfloxacin-Capped Gold Nanoparicle memilki kemampuan deteksi mencapai 25 hingga 350 µM lebih sensitif karena mengandung partikel nano yang disintesis dengan agen antijamur dan bakteri sparfloxacin. Pada biosensor Enzim amperometrik batas deteksi dapat mecapai 0.01% hingga 0.1% (100-1000 mg/dL) yang cukup sensitif untuk dijadikan sebagai biosensor dalam deteksi alkohol. Wearable electrochemical alcohol biosensor memiliki batas deteksi kisaran 0,1-1,0 g/d, ,sedangkan breathalyzer batas deteksi kadar etanol dalam napas setara dengan kadar alkohol dalam darah (BAC) dari 0,01% hingga 0,2% (100-2000 mg/dL). Kesimpulan menunujukan bahwa pengembangan biosensor untuk deteksi alkohol memilki sensitivitas yang tinggi yang bermanfaat dalam aplikasi bioforensik atau deteksi kesehatan lainnya. Sensitivitas biosensor ini meliputi biosensor berbasis Sparfloxacin-Capped Gold Nanoparicle, kemudian biosensor berbasis enzim amperometrik, biosensor berbasis wearable electrochemical alcohol biosensor dan breathlizer.
Co-Authors Hakim, Elsya Bayduri Haryanto Haryanto Lathifah, Hasna Labib Luthfi, Cahya Arsya Najah, Adilla Syahsiyatun Raflianti, Desti Salsabila, Anbar Rania Salsabila, Aulia Putri Sulasikin, Almaydha Naim Wibawa, Alifah Mustari Mukti