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GAMBARAN KESESUAIAN DOSIS TERAPI CAIRAN, HEMATOKRIT, TROMBOSIT, LAMA RAWAT PASIEN DBD ANAK DI RUMAH SAKIT ISLAM BOGOR Paloma, Yacinta; Nurafni, Silvi; Fawwaz, Kahlaa Nabiilah
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 1 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i1.8610

Abstract

Demam berdarah dengue (DBD) merupakan salah satu penyakit menular yang ditularkan oleh gigitan nyamuk Aedes aegypti yang banyak menyerang anak-anak. Prinsip utama pengobatan DBD adalah terapi suportif dan pemeliharaan volume cairan sirkulasi. Seseorang yang terinfeksi DBD dapat ditandai dengan adanya kebocoran plasma seperti peningkatan hematokrit dan penurunan jumlah trombosit. Penelitian ini bertujuan untuk mengetahui gambaran kesesuaian dosis terapi cairan, hematokrit, trombosit dan lama rawat pasien DBD pada anak yang dirawat di Rumah Sakit Islam Bogor. Metode yang digunakan dalam penelitian ini yaitu metode analitik observasional, dengan rancangan penelitian cross sectional. Data diambil dari rekam medik pasien selama bulan Januari-Desember 2024 dengan sampel sebanyak 59 pasien. Hasil penelitian menunjukkan bahwa dari 59 pasien, sebanyak 54,20% pasien menjalani terapi cairan dengan dosis sesuai dengan nilai hematokrit terbanyak yaitu 33-38%, nilai trombosit terbanyak yaitu 50.000-100.000 sel/μL dan lama rawat terbanyak yaitu ≤ 4 hari. Kesimpulan yang diperoleh dari penelitian ini adalah sebanyak 54,20% pasien DBD pada anak di RS Islam Bogor periode Januari-Desember 2024 mendapatkan dosis terapi cairan yang sesuai dengan pedoman tatalaksana DBD menurut Kemenkes tahun 2021, memiliki nilai hematokrit yang sesuai sebanyak 40,7%, trombosit yang sesuai sebanyak 33,8% dan lama rawat ≤ 4 hari sebanyak 32,2%.Kata kunci: DBD, Hematokrit, Lama Rawat, Terapi Cairan, Trombosit.
EFFECT OF ETHANOL CONCENTRATION OF LIQUORICE EXTRACT (Glycyrrhiza glabra L.) IN SUNSCREEN BODY LOTION PREPARATIONS TOPHYSICAL PROPERTIES, PHYSICAL STABILITY AND ANTIOXIDANT ACTIVITY (SPF) Seftiani, Dita; Paloma, Yacinta
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 8, No 2 (2023)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v8i2.6250

Abstract

AbstractLiquorice (Glycyrrhiza glabra L.) is a plant that has an interactive effect of UV protective, antiinflammatory & antioxidant activity responsible for exerting useful effects on the skin. Liquorice contains chemical components such as sugars, flavonoids, sterols, starch, amino acids, essential oil resins and saponins.This study aims to determine the effect of sweet root extract (Glycyrrhiza glabra L.) to the value of sun protection factor (SPF), physical properties and physical stability of sunscreen body lotion preparations. Preparation of Body lotion Sunscreen liquorice extract made five formulas with variations in concentration 7.5%; 12%; 15%; 18%; and 20%. Then conducted phytochemical screening terjadap sweet root extract, the made the formulation of Body lotion Sunscreen sweet root extract (Glycyrrhiza glabra L.), then measured the SPF value of the preparation of sunscreen body lotion sweet root extract (Glycyrrhiza glabra L.) with UV spectrophotometer. Physical properties such as viscosity, pH, adhesion and dispersion tests were tested by linear regression. Physical stability (viscosity test, pH test, dispersion and adhesion test) analysis using Anova one way test method. Determination of SPF value, organoleptic test, homogeneity and emulsion type descriptively. Physical properties of the five formulas have a characteristic liquorice odor, lotion shape, yellowish brown color on F1 and dark brown on F2, F3, F4 and F5, preparation of a homogeneous liquorice extract body lotion. The higher the concentration of the extract in the body lotion, the viscosity and adhesion increased, while the pH and dispersion decreased. Physical stability of the five formulas with concentrations of FI (7.5%), FII (12%), F3 (15%), F4 (18%) and F5 (20%) stable in terms of homogeneity test and organoleptic tests include odor,shape and color of FI (7.5%) on days 0 and 7 stable, but lotion on Days 14, 21 and 28 oxidation with discoloration or unstable. The five formulations on viscosity, pH, adhesion and dispersibility tests during 28-day storage at room temperature 270C were unstable. Liquorice extract (Glycyrrhiza glabra L.) with variations in concentration F1(7.5%); F2 (12%); F3 (15%); F4 (18%) and F5 (20%) have Sun Protection Factor (SPF) values respectively 1.72; 17.83; 21.17; 23.32 and 32.32, the five formulas are included in the ultra Protection category range (>15).Keywords: Sweet Root, Body Lotion, Sun Protection Factor (SPF)